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Topical compositions comprising diaminooxidase for the treatment or prevention of diseases associated with high histamine levels which involve an increase in pain

a technology of diaminooxidase and composition, which is applied in the direction of bandages, oil/fat/waxes non-active ingredients, peptide/protein ingredients, etc., can solve the problem that the patent does not consider topical compositions or the use thereof for the treatment of migraines, and the concentration of free circulating histamine is high, so as to achieve the effect of low histamine-rich and/or histamine-releasing food and increase pain

Inactive Publication Date: 2016-01-28
DR HEALTHCARE ESPANA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides topical pharmaceutical compositions comprising D-amino oxidase (DAO) that can be used to prevent or treat diseases or conditions associated with high levels of histamine in blood, such as migraine, fibromyalgia, spondylitis, and muscle contractures. The compositions come in various forms such as creams, serums, gels, and sprays, and can be applied using medical devices or sanitary products. The invention also includes a manufacturing process for the topical compositions and the use of the compositions together with a diet low in histamine-rich and / or histamine releasing food.

Problems solved by technology

High concentrations of free circulating histamine trigger undesirable effects, such as headaches, nasal congestion or rhinorrhea, respiratory tract obstruction, tachycardia, gastric and intestinal ailments, swelling of the eyelids, cutaneous erythemas, low blood pressure, bronchospasms, etc.
The presence of these free amines in certain foods is considered to be a cause of migraines.
This patent does not consider topical compositions or the use thereof for the treatment of migraines, or other painful pathologies, such as fibromyalgia, spondylitis and muscle contractures.
In the last few years, FM has become more important and currently is a major public health problem given its high prevalence, the lack of knowledge about causes and mechanisms, the absence of a curative treatment and the dissatisfaction of patients and professionals.
Most recent data also indicates that in patients with FM, there is an alteration of the mechanisms of pain processing, probably caused by an imbalance in neuromodulators of the central nervous system.

Method used

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  • Topical compositions comprising diaminooxidase for the treatment or prevention of diseases associated with high histamine levels which involve an increase in pain

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051]A topical pharmaceutical composition was prepared in the form of an oil / water (o / w) cream containing 2% of DAO.

Ingredients% (weight / weight)Disodium EDTA0.3Imidazolidinyl urea (Abiol)0.2Mixture of parabens in phenoxyethanol0.85(Phenonip)Potassium cetyl phosphate (Arlatone Map3160K)Ethylhexyl cocoate (Waglinol 13088)2.5C12-C15 alkyl benzoate (Finsolv TN)5.0Cetearyl alcohol, cetearyl glucoside5.0(Montanov 68)Menthyl lactate (Frescolat)0.3Dimethicone (DC 200 silicone)1.0Tocopheryl acetate (Vitamin E acetate)0.5Polyacrylamide, water, C13-142.0isoparaffin, Laureth-7 (Sepigel)Fragrance (perfume)0.3DAO2Waters.q.

example 2

[0052]A topical pharmaceutical composition was prepared in the form of a water / oil (w / o) cream containing 3% of DAO.

Ingredients% (weight / weight)Disodium EDTA0.3Imidazolidinyl urea (Abiol)0.2Glycerin3.0Magnesium sulfate1.0Aloe Vera gel1.0Mineral oil15.0Ethylhexyl cocoate (Waglinol 13088)10.0Cera Alba (Permulgin 1550)1.5Mixture of parabens in phenoxyethanol0.85(Phenonip)Hydrogenated castor oil (Cutina HR)0.75Sorbitan sesquioleate (Arlacel 83)3.0BHT0.05Jojoba seed oil0.5Fragrance (perfume)0.3Magnesium sulfate2.0DAO3Waters.q.

example 3

[0053]A topical pharmaceutical composition was prepared in the form of a serum containing 1.5% of DAO.

Ingredients% (weight / weight)Disodium EDTA0.3Imidazolidinyl urea (Abiol)0.2Mixture of parabens in phenoxyethanol0.85(Phenonip)Water, glycerin, glyceryl polyacrylate8.0(Hispagel)PEG-40 hydrogenated castor oil0.6(Cremofor CO 40)Carbomer (Ultrez 10)0.5Propylene glycol3.0Glycerin5.0Butylene glycol1.0Fragrance (perfume)0.3DAO1.5Waters.q.

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Abstract

The present invention relates to a pharmaceutical, cosmetic or dermo-cosmetic composition that comprises DAO, for use in the prevention or treatment of diseases or pathological conditions associated with high levels of histamine in blood which involve an increase in pain, preferably fibromyalgia, characterised in that the application of the composition is topical.

Description

FIELD OF THE INVENTION[0001]The present invention relates to topical pharmaceutical, cosmetic or dermo-cosmetic compositions comprising diaminooxidase (DAO) for the treatment or prevention of diseases and pathological conditions associated with high levels of histamine in blood which involve an increase in pain, in particular for the treatment or prevention of migraine, fibromyalgia, spondylitis and muscle contractures.BACKGROUND OF THE INVENTION[0002]Histamine[2-(4-imidazolyl)-ethylamine] is an important mediator in many biological processes, including inflammation, the secretion of gastric acid, neuromodulation and regulation of the immune function. Due to its potent pharmacological activity, even at very low concentrations it is necessary to carefully regulate the synthesis, transport, storage, release and degradation of histamine in order to prevent undesirable reactions. High concentrations of free circulating histamine trigger undesirable effects, such as headaches, nasal cong...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N9/06
CPCC12N9/0022A61K38/44C12Y104/03022A61K9/0014A61K47/10A61K47/14A61K47/24A61K47/32A61K47/44A61K9/7046
Inventor DUELO RIU, CARLOSDUELO RIU, JUAN JOSE
Owner DR HEALTHCARE ESPANA