Cartilage repair, preservation and growth by stimulation of bone-chondral interface and delivery system and methods therefor

Abstract

Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. Alternatively, for disc repair, a delivery device directed to percutaneous intradiscal annular repair, or “PIARES” device can be used to introduce therapeutics intradiscally. The device may have two-needles, with a first cannula / needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a continuation of U.S. patent application Ser. No. 13 / 861,360, filed Apr. 11, 2013, now U.S. Pat. No. 9,827,010, which claims priority to U.S. Provisional Patent Applications No. 61 / 686,835, filed on Apr. 11, 2012, and 61 / 800,574, filed on Mar. 15, 2013, each entitled “CARTILAGE REPAIR, PRESERVATION AND GROWTH BY STIMULATION OF BONE-CHONDRAL INTERPHASE AND DELIVERY SYSTEM AND METHODS THEREFOR”, and each of which is hereby incorporated herein by reference.TECHNICAL FIELD[0002]The present invention relates to various novel treatments for degenerative joints and discs, and improved devices and therapies for the delivery of therapeutic agents to hard to reach anatomical areas with minimal trauma so as to better implement such novel treatments.BACKGROUND OF THE INVENTION[0003]Conventional Therapies for Degenerative Disc and Other Cartilage Disease[0004]Considering knee degeneration or osteoarthritis (“OA”) as an exam...

AI Technical Summary

Benefits of technology

The solution reduces the risk of infection, minimizes trauma, and achieves effective cartilage repair and regeneration with fewer complications and lower healthcare costs compared to traditional methods, as demonstrated by increased cartilage growth and reduced pain in clinical trials.

Problems solved by technology

Although these medications decrease inflammation and pain, their prolonged use (i) is thought to have an adverse impact on cartilage and (ii) comes with complications of increased risk of hypertension, coronary artery disease, renal failure (especially in diabetics) and peptic ulcer disease.

However, it has limited success rates in treating knee OA.

Thus, while some studies show good success rates, others show rather poor ones.

Furthermore, success rates decrease substantially in those patients with moderate to severe knee OA.

This technique has seen limited success rates.

However, if done excessively, microfracture can sometimes even accelerate the rate of cartilage loss.

These procedures have significant complication rates of blood clots and infections, are expensive, require hospital stays, have the associated liability of inserting metal in the body, and come with markedly increased healthcare costs.

Each time internal tissues are exposed in this way the risk of infection increases.

Furthermore, this is technically more challenging and time consuming with increased risk of complications.

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