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Cannabinoid compositions with high solubility and bioavailability

a cannabinoid composition and solubility technology, applied in the field of cannabinoid compositions with high solubility and bioavailability, can solve the problems of limited form and mode of administration, low bioavailability, and significant low oral bioavailability of cannabinoids, so as to improve the solubility of cannabinoid, and improve the solubility of the substan

Pending Publication Date: 2022-10-06
PISAK MEHMET NEVZAT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to an oral composition that can be in solid, semi-solid or liquid form. The composition allows for improved solubility and bioavailability of the cannabinoid compound, which is typically in oil or liquid form in other products. The composition includes a cannabinoid compound, an emulsifier, a silica derivative, a cyclodextrin compound, and optionally an emulsifier. The composition has improved stability and does not impair the mucosal barrier or increase permeability of the gut. The amount of cannabinoid compound in the composition ranges from 10% to 90%, with the amount of emulsifier ranging from 15% to 75% and the amount of silica derivative ranging from 1% to 70%. The combination of these components provides improved solubility, bioavailability, and stability of the cannabinoid compound.

Problems solved by technology

They both act through cannabinoid receptors and have therapeutic effects, but THC has psychoactive properties whereas CBD is not intoxicating under normal circumstances.
Oral bioavailability of cannabinoids is significantly low compared to inhalation and this poses a health issue wherein most of the patients are inevitably guided towards smoking compounds with cannabinoid content in order to get their full benefit.
They also have very low bioavailability which limits the form and mode of administration.
However, the effectiveness of cannabinoids as a medicinal product, supplement or functional food / beverage is all limited due to its low bioavailability (BA) caused by the poor absorption of cannabinoids due to low solubility and low permeability.
Thus, it is difficult to obtain effective blood concentrations.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0108]

IngredientAmount (g)CBD(98.6%)4000β-cyclodextrin1000stearoyl polyoxyl-32 glyceride (Acconon C-400050)Aeroperl 300 (colloidal silicon dioxide)500

Manufacturing Process

[0109]1. 4000 grams of CBD and 1000 grams of beta-cyclodextrin are weighed and mixed by using a cubic mixer at 80 rpm for 5 minutes.

2. 4000 grams of Acconon C-50 is weighed and grinded until Acconon C50 is in powder form.

3. Acconon C-50 is added along with Aeroperl 300 to the mixed powder in step 1 and mixed in the cubic mixer at 80 rpm for 15 min.

4. Mixed powder is passed through a 0.5-mm sieve.

example 2

[0110]

IngredientAmount (g)CBD(98.6%)4000β-cyclodextrin1000Polysorbate 804000Colloidal silicon dioxide (Aeroperl 300)3000

Manufacturing Process

[0111]1. 4000 grams of CBD and 4000 grams of polysorbate 80 is weighed and mixed in a high sheer mixer at 300 rpm for 25 minutes.[0112]2. 1000 grams of β-cyclodextrin is weighed and added into the mixture described in step 1 and mixed for 5 minutes[0113]3. 1000 grams of Aeroperl 300 is slowly added in 20 minutes (to prevent clumps) to the mixture in step 2, whilst mixing at 50 rpm[0114]4. The resulting powder from step 3 is sieved by 500 um steinless steel sieve

example 3

[0115]

IngredientAmount (g)CBD distillate (40% CBD)4000β-cyclodextrin1000Polysorbate 804000Colloidal silicon dioxide (Aeroperl 300)6000

Manufacturing Process

[0116]1. 4000 grams of CBD distillate and 4000 grams of polysorbate 80 is weighed and mixed in a high sheer mixer at 300 rpm for 25 minutes.[0117]2. 1000 grams of β-cyclodextrin is weighed and added into the mixture described in step 1 and mixed for 5 minutes[0118]3. 6000 grams of Aeroperl 300 is slowly added in about 20 minutes (to prevent clumps) to the mixture in step 2, whilst mixing at 50 rpm[0119]4. The resulting powder from step 3 is sieved by 500 um stainless steel sieve

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Abstract

The present invention is based on the highly soluble and bioavailable cannabinoid compositions which can be made at a commercial scale with a simple manufacturing process. Thus, the present invention relates to oral compositions comprising a cannabinoid compound, for use in the nutraceutical, pharmaceutical, food or beverage industries and its production methods.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition comprising a cannabinoid compound, at least one emulsifier, at least one cyclodextrin compound and at least one silica derivative to be used in oral formulations.BACKGROUND ART[0002]Plants within the genus Cannabis, have been cultivated for thousands of years in many parts of the world and has three main subspecies: Indica, sativa, and ruderalis. Medical preparations of the cannabis plant have been observed to produce analgesic, anti-anxiety, anti-spasmodic, muscle relaxant, anti-inflammatory and anticonvulsant effects among many others. It is also of note that cannabinoids are being used for the treatment of cancer, and cancer related applications such as chemotherapy induced nausea and several different neurological disorders including Parkinson's and epilepsy. The cannabinoids within the cannabis plant can also be further isolated to increase the amount of a particular cannabinoid within a composition.[0003]Canna...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/05A61K9/20
CPCA61K31/352A61K31/05A61K9/205A61K9/2018A61K9/2009A61K9/143A61K9/006A61K9/2095A61K9/0056A61K31/192A61K9/0053A61K9/107A61K47/02A61K47/12A61K47/40
Inventor PISAK, MEHMET NEVZAT
Owner PISAK MEHMET NEVZAT