Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals

a technology of memory loss and recovery time, applied in the field of compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals, can solve the problems of age-dependent decrease in anaesthesia requirements, achieve improved water maze performance of rats, increase intracellular calcium, and improve the effect of calcium level
US6251942B1Inactive Publication Date: 2001-06-26CARLEN PETER LOUIS
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
CARLEN PETER LOUIS
Publication Date
2001-06-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a non-toxic, enhancing effective amount of a cell membrane permeant calcium buffer. The buffer is preferably a calcium ion chelating agent having a KD selected from the range 1x10-4 to 1x10-8 Molar and being essentially calcium ion-selective over other metal ions. A most preferred buffer is BAPTA-AM.
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Description

This invention relates to methods of alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals using a cell membrane permeant calcium buffer, said calcium buffers per se, pharmaceutical compositions comprising said calcium buffers and methods for the preparation of said pharmaceutical compositions.Progressive learning and memory impairment occurs during the normal course of aging (1,2,3). A strong functional link has been established between the hippocampal region of the brain and learning and memory of spatial information (4,5,6). Also, age-related changes in neuroanatomical, neurochemical and neurophysiological parameters of this structure of the brain have been well documented and causally linked to the etiology of memory impairment (5,7,8). This age-dependent impairment of spatial learning is strongly correlated with a deficit in the maintenance of neuronal activity long-term potentiation (LTP) in the hippocampus (9). LTP, a form of sy...

Claims

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