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Method for treating a periodontal disease

a periodontal disease and improved method technology, applied in the direction of antibacterial agents, biocide, bandages, etc., can solve the problems of difficult control, difficult to carry out the dose of the drug solidifying therein, and none of the above mentioned formulations are particularly effective, so as to achieve the effect of improving the therapeutic

Active Publication Date: 2014-10-21
DEXCEL PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach allows for improved therapeutic results with increased frequency of administration, achieving significant reductions in periodontal pocket depth and promoting bone growth, as demonstrated by clinical studies showing enhanced bone gain and reduced bone loss.

Problems solved by technology

None of the above mentioned formulations are particularly efficacious in causing alveolar bone regrowth or even in arresting alveolar bone resorption.
Stringing an exact dose of a gel into a body crevice such as a periodontal pocket and having a known dose of the drug solidifying therein is difficult to carry out and difficult to control.

Method used

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  • Method for treating a periodontal disease
  • Method for treating a periodontal disease

Examples

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example 1

[0074]The efficacy of the FBP chip was investigated under 2 different clinical protocols and PPD reduction was measured in mm. In the first clinical study the FBP Chip was inserted into the periodontal pocket every 6 weeks. In the second clinical study the FBP Chip was inserted into the periodontal pocket every week for the first month and every other week for the second month.

[0075]The results are presented in FIG. 1. It may be seen that while the every 6 Wks. protocol resulted in a PPD reduction of 1.86 mm after 6 months, the every 1-2 Wks. protocol resulted in a PPD reduction of 2.33 mm after only 2 months. Thus, it may be seen that the increased frequency of insertion gave superior results.

example 2

[0076]The efficacy of the CHX chip was investigated under 3 different clinical protocols and PPD reduction was measured in mm. In the first clinical study CHX was inserted into the periodontal pocket every 3 months. In the second clinical study CHX Chip was inserted into the periodontal pocket every 6 Wks. In the third clinical study CHX Chip was inserted into the periodontal pocket every week for the first month and every other week for the second month.

[0077]The results are presented in FIG. 2. It may be seen that while the CHX Chip every 3 months protocol resulted in a PPD reduction of 0.95 mm after 9 months, the protocol of every 6 Wks resulted in a PPD reduction of 1.62 mm after 6 months and the protocol of CHX Chip every 1-2 Wks resulted in a further PPD reduction of 2.08 mm after only 2 months.

[0078]Conclusion: increased frequency of chip insertion containing either CHX or FBP into periodontal pockets resulted in a significant improvement in the periodontal condition in the p...

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Abstract

Provided is a method for treating a periodontal disease affecting a periodontal pocket of a patient. The method includes inserting an oral delivery device into the periodontal pocket at a frequency of about once every 4 days to about once every 6 weeks. The oral delivery device is a controlled release solid unit dosage form suitable for insertion into a periodontal pocket of a patient, including a therapeutically effective amount of at least one anti-inflammatory agent, at least one antibacterial agent, or the combination of at least one anti-inflammatory agent and at least one antibacterial agent.

Description

[0001]This is a Non-Provisional Application filed as an application claiming the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application No. 61 / 406,288, filed on Oct. 25, 2010, the content of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]This invention relates to an improved method for treating a periodontal disease.BACKGROUND OF THE INVENTION[0003]Local delivery systems (LDS) of antibacterial agents have shown beneficial effect on pocket reduction and inflammation in chronic periodontitis patients. An example of such a system is the Periochip®. PerioChip® (chlorhexidine gluconate) is a small, rectangular chip for insertion into periodontal pockets. Each PerioChip contains 2.5 mg of chlorhexidine gluconate in a biodegradable matrix of hydrolyzed gelatin (cross-linked with glutaraldehyde). PerioChip also contains glycerin and purified water. Treatment is recommended to be administered once every three months in pockets with a remaining ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K47/10A61K9/00A61K47/42A61K9/70A61K31/192A61F13/00
CPCA61K47/10A61K47/42A61K9/7007A61K9/0063A61K31/192A61K31/155A61P31/04
Inventor AVRAMOFF, AVISHOSHANI, EYALPENHASI, ADELOREN, DAN
Owner DEXCEL PHARMA TECH