Breath test analyzer

Inactive Publication Date: 2005-04-19
EXALENZ BIOSCIENCE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0039]The present invention seeks to provide an improved breath test analyzer which overcomes disadvantages and drawbacks of existing analyzers, which provides accurate results on-site in times of the order of minutes, and which is capable of implementation as a low cost, low volume and weight, portable instrument. The breath a

Problems solved by technology

In addition, carbon-14 is still used in some procedures, but being radioactive, there are severe disadvantages both to its ingestion by the patient, and because of the storage, handling and disposal precautions required at the test site.
Previously available tests for these illnesses generally involve drastically more invasive procedures, and are therefore much less patient compliant than the simple breath tests described above.
Furthermore, there are other disadvantages to the previously used tests, such as the fact that they rarely give real time information about the organ function or status being observed.
However, in spite of the advantages of isotopically labeled breath tests, current instrumentation and procedures for performing it sill have a number of serious drawbacks, which continue to limit its usefulness.
The major disadvantage, which becomes apparent when a review of prior art breath test performance techniques and instrumentation is performed, is that none of the currently used techniques are sufficiently rapid to permit immediate measurement of the requested parameter, allowing a diagnosis for the patient in a single short visit to the physicians office.
Clearly this method cannot be used to provide the results of the test within the context of a single visit to the office of the physician.
Such a long delay to obtain breath samples, as well as the long wait between samples, is inconvenient and potentially reduces patient compliance.
Furthermore, as in the previously mentioned prior art, the sample or samples are collected from the patient and then sent to a laboratory for analysis, causing a delay in the determination of the results and forcing the subject to return to the office of the physician to obtain the results.
The requirement for multiple office visits potentially further reduces patient compliance.
The potential reduction in patient compliance can have serious consequences, since Helicobacter pylori is implicated by the World Health Organisation as a possible cause of stomach cancer, in addition to its role in gastric and duodenal ulcers.
This test thus has all the disadvantages of the use of radio

Method used

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Example

[0083]Reference is now made to FIG. 1, which is a schematic view of a compact high sensitivity breath analyzer constructed and operative in accordance with a preferred embodiment of the present invention. The breath analysis is performed by a sensitive non-dispersive infra-red spectrophotometer, capable of discriminating between the isotopically labeled CO2 and the natural CO2 in the breath sample being analyzed.

[0084]The patient is connected to the breath analyzer by means of the inlet tube 10, which can be either a nasal cannula or a breathing tube. Such a cannula includes a section of tubing, usually plastic, with two prongs. Each prong is inserted into a nostril and the cannula is then connected to the measuring instrument. As the patient exhales through the nose, a sample of the exhaled air flows through the cannula to the analyzer. A preferred type of breathing tube is constructed of a hollow tube held in the patient's mouth, through which he blows a number of breaths. In the ...

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Abstract

A breath test analyzer, which analyzes exhaled breadths of a patient for isotope labeled products generated in the patient's body after ingestion by the patient of an isotope labeled substance, where the presence of these isotope labeled products provide an indication of a medical condition in the patient. The analyzer uses a very sensitive infra-red spectrophotometer, which enables it to continuously collect and analyze multiple samples of the patient's breath, and process the outputs in real time, while the patient is still connected to the analyzer, such that a definitive result is obtained within a short time, such as the order of a few minutes. The breath test analyzer is sufficiently small in that it can be easily accommodated in the office of a physician. The breath test analyzer can be utilized for a number of diagnostic breath tests, according to the isotope labeled substance ingested by the patient and the gases detected in the patient's breath.

Description

CROSS REFERENCE TO RELATED APPLICATION[0001]This is a continuation-in-part of commonly-assigned U.S. patent application Ser. No. 08 / 805,415, filed Feb. 26, 1997 now U.S. Pat. No. 6,067,989.FIELD OF THE INVENTION[0002]The invention relates to the field of analyzers of the breath of patients to detect the gastric by-products of various diseases and infections.BACKGROUND OF THE INVENTION[0003]Since the early 1950's, it has been known that the presence of bacterial organisms in the gastro-intestinal tract is accompanied by a high concentration of urease, which hydrolyses urea to form carbon dioxide and ammonia. These gases are detected in the subject's blood stream and ultimately, in the subject's breath, if he had been administered isotopically labeled urea. Such early results appear in reviews published by R. W. VonKorff et al. in Am. J. Physiol., Vol. 165, pp. 688-694, 1951, and by H. L. Kornberg and R. E. Davies in Physiol. Rev., Vol. 35, pp. 169-177, 1955.[0004]Since these early ex...

Claims

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Application Information

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IPC IPC(8): A61B5/083A61B5/08G01N21/31G01N21/35G01N33/00
CPCA61B5/0836A61B5/7239G01N21/3504G01N33/0006
Inventor KATZMAN, DANIEL E.CARLEBACH, EPHRAIM
Owner EXALENZ BIOSCIENCE LTD
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