The invention discloses a centering pixel extracting method for a spherical LED display screen. According to the method, the distances between adjacent rows of pixels are equal on the same meridian of a spherical body, and pixels on the same parallel are distributed according to the rule that if X/Y=2K, even pixel extraction is conducted to reduce the number of pixels with the K as the sector number, if X/Y=2K+1, centering pixels of X are changed firstly, then pixels are changed evenly with the center pixel as the center of horizontal symmetry and Y-1 as the sector number, wherein X is the number of pixels on the parallel, Y is the number of pixels needing to be changed, K is a natural number, and X,Y and K are all integers. The centering pixel extracting method for the spherical LED display screen is high in universality, suitable for LED spherical display screens in various radii, and capable of increasing the utilization rate of pixel points (lamp beads). Furthermore, pixels are arranged reasonably, waste can not be caused, and energy is saved.