33results about How to "Avoid premature degradation" patented technology

The present invention generally relates to compounds comprising antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to TROP2 (TACSTD2). The present invention also relates to methods of using such TROP2-binding molecules for diagnosing and treating diseases, such as malignancies.

Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen binding unit (Drug-Linker-Antigen binding Unit: D-L-Abu), for targeted delivery to disease tissues. D-L-Abu, D-L-Abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided.

The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.

An engine control device includes an electronic control unit. The electronic control unit is configured to perform a spark discharge with an ignition plug for each cylinder by cutting off energization after elapse of a predetermined period from start of energization to an ignition coil for each cylinder of the engine, to stop the spark discharge caused by the ignition plug for each cylinder after supply of fuel to the engine is stopped when operation of the engine is stopped, and to control an ignition plug so as to stop the spark discharge caused by the ignition plug from a cylinder after a rotation speed of a crankshaft decreases gradually and the rotation speed of the crankshaft reaches a preset threshold value or less, after the stop of the supply of fuel to the engine.

Disclosed herein are anti-ERB B2 / NEU antibodies conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods relating to the preparation and uses of such drug conjugates to treat ERB B2 / NEU positive cells in cancers are provided.

The invention relates to a collagen cross-linker composition and an application thereof. The composition comprises a photosensitive cross-linker, a chemical cross-linker, citrate and imidazole. By using the cross-linker composition, the chemical crosslinking and photo-oxidation of decellularized collagen can be carried out simultaneously, and synergism is exerted, so that the efficiency of a cross-linking reaction is increased, and a cross-linked collagen medical material with higher quality is obtained.

Molecular probes to particular targets may be nucleic acids that may generally possess resistance to degradation when bound to a target molecule. For example, the molecular probes may be generally resistant to nuclease degradation when bound to their target molecules, and generally not resistant to nuclease degradation when unbound to their target molecules. This may be utilized, for example, to selectively degrade unbound molecular probes while preserving the bound molecular probes, which may thus serve as an indication of the presence of their target molecules in a sample.

The invention discloses a preparation method of an externally constructed tissue engineering trachea matrix. The preparation method comprises the following steps: pretreatments including fat removing and blood cleaning are performed on fresh allogeneic trachea tissue or xenogenic trachea tissue; then trachea tissue impurities and tissue cells are removed through the combination of a chemical method and a biological enzyme method, and finally, a photooxidation cross-linking reaction is adopted for adjusting the crosslink level of a trachea matrix framework of which the tissue cells are removed; and through the method, the tissue engineering trachea matrix which is good in stability and beneficial to seed cell seeding, attachment and proliferation can be obtained.

The present invention relates to a process for producing butadiene from ethanol, in two reaction steps, comprising a step a) of converting ethanol into acetaldehyde and a step b) of conversion into butadiene, said step b) simultaneously implementing a reaction step and a regeneration step in (n+n / 2) fixed-bed reactors, n being equal to 2 or a multiple thereof, comprising a catalyst, said regeneration step comprising four successive regeneration phases, said step b) also implementing a regeneration loop for the inert gas and at least one regeneration loop for the gas streams comprising oxygen.

The invention discloses a drainage prevention combined self-adhesion waterproof plate for a mining method underground tunnel. The drainage prevention combined self-adhesion waterproof plate comprisesa hook-and-loop fastener band, a drainage layer formed by multiple convex points, an HDPE waterproof plate layer, a macromolecule hot-melt pressure-sensitive adhesive layer and an anti-adhesion coating. The invention further provides a construction method of the drainage prevention combined self-adhesion waterproof plate. The waterproof plate can guide drainage, and unsmooth drainage of surrounding rock water or scouring to anchoring and shotcreting concrete is avoided. In addition, the waterproof plate can sufficiently adhere to secondary lining concrete, water channeling is avoided, the secondary lining concrete is sufficiently protected while the hidden danger of leakage is greatly reduced, the service life of the tunnel is prolonged, and the driving safety is greatly improved; and dueto the fact that the drainage effect is good, circumferential and longitudinal drainage blind pipes in a conventional method can be omitted, the construction period can be shortened, and the manufacturing cost can be reduced.

Provided herein is a hydraulic fracturing fluid containing enzyme encapsulated hydrogel nanoparticles and a breaker composition of a viscosifier-degrading enzyme encapsulated in the hydrogel nanoparticle. Also provided are methods for hydraulic fracturing utilizing hydrogel nanoparticles encapsulating an enzyme as a breaker to prevent the premature degradation of the fracturing fluid, to improve transport and placement of the proppant and to facilitate subsequent cleaning of the fracturing fluid.

Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen binding unit (Drug-Linker-Antigen binding Unit: D-L-Abu), for targeted delivery to disease tissues. D-L-Abu, D-L-Abu derivatives, and methods relating to the use of such drug conjugates to treat antigen positive cells in cancers and immunological disorders are provided.

Nucleic acids are prepared by dissolving compounds containg them in a suitable solvent or solvent system and forming microspheres from the resulting solution. The microspheres are administered to an individual as protection from conditions where delivery of nucleic acids is useful, such as in treatment of autoimmune disease.

Disclosed herein are anti-CD20 antibody conjugated with maytansinoid drugs for targeted delivery to disease tissues. Methods related to the preparation and uses of such antibody drug conjugates to treat CD20 positive cells in cancers are provided.

The invention relates to a medical device (10) comprising: a device body (12) preferably comprising a material susceptible to corrosion or bio-degradation and a shellac coating (14), wherein the device body (12) is at least partially covered by the shellac coating (14), wherein the shellac coating (14) has a thickness from 0.1 [mu]m to 20 [mu]m. Further, the invention relates to a method for manufacturing the medical device.

The invention discloses a tumor targeting polypeptide, a polypeptide coupling drug and application of the tumor targeting polypeptide and the polypeptide coupling drug. The polypeptide sequence of the tumor targeting polypeptide is X-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-D-Gl-PEG4-Cyclo (Lys-Arg-Gly-Asp-D-Phe), the carboxyl group of the main chain of D-Phe and the amino group of the main chain of Lys form an amide ring, and PEG4 is connected with the amino group of the side chain of Lys; in the formula, X represents that the amino acid residue is Cys or does not exist. The tumor targeting polypeptide provided by the invention has targeting property and penetrability, and when the tumor targeting polypeptide is used as a carrier of a small-molecule anti-tumor drug to prepare a polypeptide coupling drug, the anti-tumor drug can directionally penetrate through cell membranes of cancer cells, release of the small-molecule drug is completed, and specific targeting therapy of tumors is carried out.

The invention belongs to the technical field of fracture fixation materials, and specifically discloses a diamondene bone screw, which is prepared from nanodiamondene with a lamellar single crystal structure and absorbable materials; It is connected by sp3 orbital hybrid carbon bonds, and the carbon atoms between layers are connected by sp2 hybrid carbon bonds; the lattice spacing of nanodiamondene is 0.21nm; the average particle size of nanodiamondene is R, 20≤ R≤500nm; the C content of nanodiamondene is 99-100%. The invention has simple structure, high strength and high safety.

An engine control device includes an electronic control unit. The electronic control unit is configured to perform a spark discharge with an ignition plug for each cylinder by cutting off energization after elapse of a predetermined period from start of energization to an ignition coil for each cylinder of the engine, to stop the spark discharge caused by the ignition plug for each cylinder after supply of fuel to the engine is stopped when operation of the engine is stopped, and to control an ignition plug so as to stop the spark discharge caused by the ignition plug from a cylinder after a rotation speed of a crankshaft decreases gradually and the rotation speed of the crankshaft reaches a preset threshold value or less, after the stop of the supply of fuel to the engine.

The invention relates to the field of thermoplastic elastomer additives, and particularly discloses a deodorant as well as application and a preparation method thereof. The deodorant comprises the following raw materials in parts by weight: 40-50 parts of silicon dioxide microspheres, 55-70 parts of silicate clay, 160-180 parts of an acidic aqueous solution, 30-35 parts of a monomer containing a functional group X and 5-9 parts of a nano pore-forming agent. The preparation method comprises the following steps of: S1, dissolving silicate clay in an acidic aqueous solution, adding a monomer containing a functional group X, heating and stirring to obtain modified silicate clay; and S2, adding silicon dioxide microspheres and a nano pore-forming agent into the modified silicate clay, uniformlystirring and mixing, heating the mixture, continuing to stir until the mixture is dried to obtain silicon dioxide-silicate gel, and carrying out nano-crushing on the silicon dioxide-silicate gel to obtain the deodorant. The deodorant disclosed by the invention can be applied to a product prepared from a thermoplastic elastomer material, and has the advantage of efficiently removing white mineraloil smell in the thermoplastic elastomer material.

The invention discloses a method for promoting cultivation of early-spring cauliflower by using a full-biodegradable film. The method comprises the following steps: 1.1, variety selection; 1.2, sowing is selected from the last ten days of September to the last ten days of December; 1.3, seedling raising; 1.4, soil preparation and fertilization; 1.5, bedding, film covering, transplanting and field planting; 1.6, field management; 1.7, binding leaves and protecting flowers; 1.8, disease and pest control; 1.9, timely harvesting: in the step 1.5, 1-2 days before field planting of the cauliflower, a white or black full-biodegradable film with the width of 1 m and the thickness of 6-10 microns is selected to cover the furrow surface. According to the method, the full-biodegradable film is utilized in cultivation of the cauliflower, temperature increasing and soil moisture conservation can be achieved in the early period of cultivation of the cauliflower, normal growth and yield of the cauliflower are not affected, natural decomposition can be achieved in the later period of growth of the cauliflower, pollution to soil is reduced, the working process of manual film mulching and uncovering can be reduced, and the yield of the cauliflower is increased. And the cost of manual film covering and uncovering treatment is reduced.

IL6 is an important cytokine and plays an important role in the processes of infection resistance, tumor immunity, immune cell development and the like, so that maintenance of a certain level of IL6 is very important in the processes of preventing the IL6 from being degraded too early. The USP11 is a gene participating in the ubiquitination process of an organism, and the research finds that the USP11 is abnormally expressed in various tumors and does not participate in the research of IL6 degradation. The invention discloses a new function of USP11, namely an effect of protecting IL6 from degradation, and provides a new target spot and idea for anti-infection and tumor treatment.