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5results about How to "Avoid premature degradation" patented technology

Sodium alginate multifunctional composite microsphere as well as preparation method and application thereof

The invention relates to the technical field of microbial probiotic preparations, in particular to a sodium alginate multifunctional composite microsphere as well as a preparation method and application thereof. The sodium alginate multifunctional composite microspheres are obtained by dissolving the carbohydrate vesicles, the traditional Chinese medicine nanoparticles and the probiotics in a sodium alginate solution and then dropwise adding the solution into a calcium chloride solution through an ionic cross-linking effect. According to the invention, the amphiphilic xylooligosaccharide-cystamine derivative with H2S response is synthesized through a click reaction on the basis of prebiotic xylooligosaccharide. And the amphipathic saccharide vesicles are obtained through self-assembly by virtue of hydrophilic and hydrophobic effects. Sanguinarine iodide prepared by purification, separation and reflux and baicalin are self-assembled in an aqueous solution through a non-covalent bond, and the traditional Chinese medicine nanoparticles are prepared through ultrasonic treatment. An in-vitro simulated release experiment proves that the sodium alginate multifunctional composite microsphere is relatively low in release rate under an acidic condition, so that substances are favorably delivered to intestinal tracts; and the release of encapsulated substances can be better realized in neutral and alkaline environments.
Owner:CHANGZHI MEDICAL COLLEGE

Antibacterial coating of stable antibacterial peptide as well as preparation method and application of antibacterial coating

ActiveCN119236192AAvoid premature degradationmaintain antimicrobial activitySurgeryCoatingsAntimicrobial peptidesOrthopedic department
The invention provides a stable antibacterial peptide antibacterial coating and a preparation method and application thereof, and the method comprises the following steps: pretreating the surface of an orthopedic external fixation frame matrix, suspending in a simulated physiological solution containing polycarboxylate, treating at 60-100 DEG C for 1-24 hours, naturally cooling to room temperature, taking out a substrate material, cleaning, and drying to obtain the stable antibacterial peptide antibacterial coating. And suspending in a solution containing the antibacterial peptide for adsorption treatment, and then rinsing and airing to obtain the antibacterial coating of the stable antibacterial peptide. The antibacterial peptide can be effectively stabilized and prevented from being degraded too early, so that the antibacterial peptide is slowly released on the orthopedic external fixing frame to play a long-acting antibacterial effect. The method is easy to implement, the coating can provide long-acting antibacterial protection, the anti-infection capacity of the orthopedic external fixing frame is improved, the antibacterial duration of the orthopedic external fixing frame is prolonged, the postoperative infection risk is reduced, postoperative recovery of a patient is promoted, the biocompatibility and the antibacterial capacity of the orthopedic external fixing frame are remarkably improved, and a new direction is provided for improvement of orthopedic fixing instruments.
Owner:RENMIN HOSPITAL OF WUHAN UNIVERSITY (HUBEI GENERAL HOSPITAL)

Biological bacterial fertilizer capable of promoting growth and development of crop roots

The invention relates to the technical field of biological bacterial fertilizers, and discloses a biological bacterial fertilizer capable of promoting growth and development of crop root systems, and the biological bacterial fertilizer is prepared from brown sugar yeast activation liquid, calcium lignosulphonate, chitosan oligosaccharide, sodium polyaspartate, superfine calcium silicate, a decomposed organic fertilizer and a variety of microbial powder. The preparation process adopts a liquid phase shielding and solid phase isolation strategy: in a liquid phase, calcium lignosulphonate is used for wrapping chitosan oligosaccharide to prevent flocculation; and sodium polyaspartate and superfine calcium silicate are premixed in the solid phase. During granulation, the acid liquid phase excites the superfine calcium silicate to generate interface micro-etching to release calcium ions. Sodium polyaspartate is isolated in a solid-phase matrix, so that after the fertilizer is buried into soil, an instantaneous flocculation phenomenon caused by direct contact between chitosan oligosaccharide with positive charges in a liquid phase and sodium polyaspartate with negative charges in a solid phase can be avoided, and the process bottleneck that a zwitterionic polymer mixed system is difficult to granulate is solved; the continuity of the granulation process is ensured; and the roundness of finished granules is improved.
Owner:BENGBU GERUN BIOTECHNOLOGY CO LTD

Enhanced method for acid production from sludge based on synergistic degradation of melanoidins by thermal hydrolysis and potassium permanganate

ActiveCN120518293BInhibitory activityAvoid premature degradationActivated sludgeAnaeromicrobium sediminis
The application discloses a sludge anaerobic acid production strengthening method based on synergistic degradation of melanoid-like substances by thermal hydrolysis and potassium permanganate, which comprises the following steps: (1) screening and removing impurities from sludge, and then performing gravity sedimentation and concentration; (2) thermal hydrolysis treatment: high-temperature and high-pressure treatment, pressure relief and cooling; (3) adding potassium permanganate for oxidation, and combining with ultrasonic dispersion; (4) anaerobic fermentation: inoculating active sludge, and controlling fermentation conditions; and (5) separating and extracting short-chain fatty acids. The application realizes the synergistic effect of thermal hydrolysis and potassium permanganate, targets the degradation of melanoid-like substances generated in the thermal hydrolysis process, eliminates the inhibition of the melanoid-like substances on anaerobic microorganisms, and promotes the efficient dissolution of organic matters in sludge. The nano manganese dioxide generated by potassium permanganate oxidation serves as an electron transfer medium, further strengthens the metabolic activity of acid-producing bacteria, and the pickling recovery rate is greater than or equal to 90%. The method makes the yield of short-chain fatty acids increase by 65% (up to 456 mg / g VS), has high efficiency and environmental protection, and provides an innovative solution for sludge resource treatment.
Owner:XIANGTAN UNIV

Safe landfill material, biological assimilation and conversion method and formula

PendingCN119095804AInhibit early degradationAvoid premature degradationTreatment using aerobic processesSolid waste disposalPlastic materialsEnvironmental engineering
Disclosed herein are methods, compositions, formulations, and closed loop systems for delaying biological assimilation of a product constructed from at least one plastic-based material component and buried within a biological environment to prevent premature release of biogas while also enhancing a subsequent biogas capture period after triggering a biological assimilation period. The final result of biological assimilation of plastic materials constructed according to the principles of the present invention in landfills is biogas that can be safely captured, small amounts of water vapor, and biomass released onto the earth. This is a real carbon neutral closed loop, and synthetic plastics starting from natural gas can be converted into renewable natural gas with almost no loss, possibly no loss.
Owner:罗伯特·德马特斯