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Aumeilazole drip pills and its preparation method

A technology of omeprazole dripping pills and omeprazole, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem of increasing the cost of medication for patients, the low rate of qualified products of dripping pills, and increasing production. Cost and other issues, to achieve the effect of reducing drug costs, high yield, and lower production costs

Active Publication Date: 2008-01-02
盐城市大丰区生产力促进中心
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Problems solved by technology

However, according to the preparation method disclosed in this patent, since the matrix in this invention patent uses PEG4000 and PEG6000, the melting point temperatures of PEG4000 and PEG6000 are all below 60°C, and the optimum temperature for coating is mostly above 60°C. The prepared dripping pills have softened or even melted at the temperature during coating, which will seriously affect the quality of the coating, as well as the quality indicators stipulated by the National Pharmacopoeia for the dropping pills - the weight difference of each pill, the roundness rate Etc., therefore make preparation technology be difficult to meet the process condition of dripping pill and coating simultaneously in industrial production, the qualified product rate of prepared dropping pill is lower, has increased production cost, thereby also indirectly increased patient's medication cost, in The practicality in industrial production is also reduced

Method used

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  • Aumeilazole drip pills and its preparation method

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Embodiment Construction

[0034] Now with several groups of specific examples, the preparation method of omeprazole dropping pills of the present invention will be further described.

[0035] 1. The test of preparing drop pills takes g as unit, gets omeprazole 500g, gets polyethylene glycol respectively 10000 , polyethylene glycol 20000 Each 500g, 750g, 1000g, take 500g, 750g, 1000g of polyoxyl 40 stearate, prepare according to the steps stipulated in the above-mentioned drop pill preparation method, and obtain 6 drug combinations of omeprazole and different composite substrates 6 groups of different experimental results were obtained, as shown in Table 1.

[0036] 2. The test of wrapping enteric coating takes 1000g of the dropping pills prepared above, weighs respectively 140g, 150g, 160g of enteric coating powder, 1260g, 1350g, 1440g of 80% ethanol solution, and carries out according to the preparation process of the above coating Preparation, the coating test of 3 dropping pills can be obtained, a...

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Abstract

A coated dripping pill of omeprazole for treating gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis, etc is prepared from omeprazole, polyethylene glycol (1000-2000) and polyalkoxyl-40 stearate.

Description

technical field [0001] The invention relates to a pharmaceutical composition suitable for gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and Zoller-Ellison syndrome (gastrinoma), in particular to omeprazole as a raw material The prepared pharmaceutical composition is an oral preparation. Background technique [0002] Peptic ulcer is a common disease all over the world. According to reports from foreign scholars. About 10% of the population suffers from ulcer disease, and the prevalence rates reported in European and American literature are not the same. The highest reaches 13.5%. The lowest was only 5.9%. The difference is quite large. The survey among Australians over the age of 15 shows that the incidence of duodenal ulcer is 3.8%, and the incidence of gastric ulcer is 0.7%. Many hospitals have conducted statistical analysis on outpatient or inpatient cases. From 1978 to 1991, the Department of Internal Medicine of Peking Union Medical College Hospit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61K9/20A61P1/04A61J3/00
Inventor 曲韵智
Owner 盐城市大丰区生产力促进中心
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