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Shangshan dripping pill for treating toxic heat and internal storage and its preparing method

A technology of dropping pills and dropping pill machines, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations. It can solve the problem of hepatic and intestinal first-pass bioavailability, which is not conducive to improving the ability of patients to seek medical treatment, and affects granule drugs. Content and other issues, to achieve the effect of improving bioavailability, drug safety, and rapid onset of action

Inactive Publication Date: 2008-02-13
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thereby affecting the efficacy of the drug, and directly affecting the therapeutic effect. Granules still have defects such as low drug content, inaccurate measurement, and inconvenient taking.
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] Now with several groups of specific examples, the preparation method of Shuangshan dripping pills of the present invention will be further described.

[0035] Group 1: Tests with a single matrix

[0036] 1. Prepare according to [Appendix: Preparation method of extract containing active pharmaceutical ingredients of mountain green tea and hawthorn] to obtain a dry powder containing active pharmaceutical ingredients of two traditional Chinese medicines, such as mountain green tea and hawthorn, and set aside;

[0037] 2. Substrate: polyethylene glycol (1000~20000) , polyoxyl 40 stearate, beta cyclodextrin, poloxamer, sodium carboxymethyl starch, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc. pharmaceutical carrier;

[0038] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0039] 4. Then prepare according to the process of [Preparation Method] 4-7, and various specifications of Shuangshan drippin...

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PUM

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Abstract

The Shuangshan dripping pill is a kind of oral medicine composition preparation with the functions of clearing away heat and toxic matter eliminating wetness and removing stagnation of Qi, for treating pharyngolaryngitis, tonsillitis, malnutrition of children, etc. It has high bioavailability, fast medicine release, fast acting, high effective component content, low cost and less toxic side effect, and the production process has no pollution. The Shuangshan dripping pill is prepared with mountain green tea, haw and other Chinese medicinal materials and matrix carrier.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and toxin-removing, damp-removing and accumulation-removing effects, and is used for the treatment of diseases such as heat-toxin accumulation syndrome pharyngitis, tonsillitis and infantile malnutrition. An oral preparation of a pharmaceutical composition prepared from extracts of active pharmaceutical ingredients of traditional Chinese medicines. Background technique [0002] According to the formula and extraction process given in the national drug standard WS-10717 (ZD-0717)-2002, Shuangshan granule is a kind of medicine that has the functions of clearing away heat and detoxification, removing dampness and eliminating accumulation. The granule preparations for the treatment of pharyngitis, tonsillitis and malnutrition in children have been clinically verified for many years, with stable quality and definite curative effect. They are commonly used pharmaceutical p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/734A61K36/82A61P11/04A61P1/14
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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