Dispersible tablet of alfuzosin hydrochloride

Abstract

The present invention belongs to the medicine technology, especially a dispersible tablet dosage form of alfuzosin hydrochloride. Compared with the existing alfuzosin hydrochloride common tablets, the alfuzosin hydrochloride dispersible tablet in accordance with the present invention exhibits remarkably improved pharmaceutical absorption rate which accelerates the clinical curative effects; and the bioavailability is also improved greatly, this may be more obvious for aged patients with lowered gastrointestinal tract absorbing functions. The present invention conquers the technology prejudice in prior art that the common tablets of alfuzosin can achieve the objective of rapid respond symptomatically and it is not necessary to and there is no room to exploit quick-effective dosage forms, resolves the individuation problem that the medicine taking time and dosage dose are regulated according to symptoms when aged benign prostate gland hyperplasy patients take alfuzosin hydrochloride medicine, and not only rapidly alleviates patient symptoms, but also avoids serious adverse reactions such as orthostatic hypotension. The present invention is convenient for aged and children patients to take medicine, with stable formulation, fast absorption, high bioavailability and few adverse reaction.

Description

technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] Benign Prostatic Hyperplasia (BPH) is a common disease in elderly men, and it is the most common cause of voiding disorders in men. The incidence increases with age, 50% of 60-year-olds, and 88% of 80-year-olds Human histological examination found hyperplasia of the prostate, some of which can develop into BPH with clinical symptoms. Prostatic hyperplasia can cause bladder neck obstruction, affect the normal function of the urinary system, produce varying degrees of voiding disorders, and eventually cause bladder and kidney lesions, leading to renal function damage and seriously affecting the quality of life of patients. [0003] Alfuzosin hydrochloride is also a quinazoline derivative, which is selective α 1 Receptor blockers have the following advantages: [0004] 1. Alpha to genitourinary tract 1 - Strong receptor selectivity [0005] In animal...

AI Technical Summary

Problems solved by technology

However, the individualization of medication is difficult to implement in clinical practice due to the cumbersome determination of blood drug concentration and difficulty in popularizing it.

Alfuzosin hydrochloride can cause severe orthostatic hypotension when the blood concentration is too high. It is an effective way to adjust the dosage and time of medication according to the clinical symptoms and adverse reactions.

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