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Acipimox composition tablet

A technology of axilimus and a composition, which is applied in the field of medicines and medicine manufacturing, can solve the problems of affecting the full absorption of medicines and difficult for patients to take, and achieve the effects of improving the solubility of the main medicine, reducing adverse reactions and being easy to control.

Active Publication Date: 2015-04-22
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a kind of acipimox composition tablet, selects chitosan nano-particle as filler, for the common preparation of acipimox, as capsule, its specification is 250mg / grain, due to disintegration and drug dissolution It is slow and affects the full absorption of the medicine. The elderly, children and patients with dysphagia often have difficulties in taking it. At the same time, there are still adverse reactions such as nausea, vomiting and loss of appetite in the treatment. The purpose of the present invention is to overcome the above shortcomings

Method used

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Experimental program
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Effect test

Embodiment 1

[0040] Using acipimox as raw material, the effects of the dosage of various excipients on the angle of repose, hardness, appearance, disintegration, friability and dissolution of the drug were investigated. The dosage of excipients in each prescription is shown in Table 1.

[0041] Sieve the raw materials and auxiliary materials separately, and set aside: acipimox, chitosan nanoparticles, hypromellose, pregelatinized starch, croscarmellose sodium, carboxymethyl starch sodium, stearic acid Magnesium was mixed according to the prescription amount, the angle of repose was measured, and the hardness, appearance, weight difference, disintegration, friability, and dissolution were measured after tableting. The results are shown in Table 2. Among them, the determination methods of hardness, appearance, weight difference, disintegration, friability and dissolution refer to the second appendix of "Chinese Pharmacopoeia" 2005 edition. Appearance: visual inspection; hardness, disintegra...

Embodiment 2

[0048] Prepare acipimox granules with prescription 3 of Example 1, take three parts and place them in a weighed flat weighing bottle, respectively place them under the conditions of RH43%, RH59%, and RH70%, place 1, 3, After 5 days, they were weighed separately to investigate the influence of different humidity on the drug, and the absorption rate of the particles was calculated. The results are shown in Table 3.

[0049] Table 3 moisture absorption rate test results

[0050] condition

[0051] It can be seen from the results in Table 3 that under the humidity condition of RH70%, the moisture absorption weight gain increases significantly, and under the condition of RH59% humidity, the moisture absorption weight gain does not change significantly. Therefore, the space humidity must be controlled below RH59% during the preparation process.

Embodiment 3

[0052] Embodiment 3: acipimox composition tablet of the present invention

[0053]

[0054] Preparation method: Pass acipimox, chitosan nanoparticles, croscarmellose sodium and carboxymethyl starch sodium through a 80-mesh sieve respectively, then mix 4000g of acipimox and 1000g of chitosan nanoparticles Mix evenly with 4000g of croscarmellose sodium, add 6500g of 4% hypromellose 50% ethanol soft material, pass through a 20 mesh sieve and make granules, control the humidity below RH59%, will make The granules are dried at 50-60°C, passed through a 18-mesh sieve, added with 4000g of sodium carboxymethyl starch and 120g of magnesium stearate, mixed evenly, punched and pressed into tablets with a Φ11mm shallow arc surface, and obtained.

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Abstract

The invention provides an acipimox composition tablet, and belongs to the field of medicine and medicine production technology. The acipimox composition capsule comprises following raw materials and auxiliary materials, by weight, 400 parts of acipimox, 100 parts of chitosan nanoparticle, 400 parts of croscarmellose sodium, 650 parts of 4% hydroxypropyl methylcellulose 50% ethanol, 400 parts of carboxy methyl starch, and 12 parts of magnesium stearate. Advantages of the acipimox composition tablet are that: main drug solubility is improved further, that is to say, a uniform viscous suspension is obtained rapidly when the acipimox composition tablet is contacted with water, so that fine particles are obtained rapidly in gastrointestinal tract by disintegration, drug distribution area is enlarged, absorption points are increased, overhigh local drug concentration in gastrointestinal tract caused by common tablets and capsules is avoided, irritation on gastrointestinal mucosa is avoided, untoward effects are reduced, and adaptability of patients is increased. The acipimox composition tablet is convenient for patients to take; absorption speed is fast; and bioavailability is high.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to an acipimox composition tablet. Background technique: [0002] In recent years, with changes in eating habits, improvements in living standards, and increased work pressure, there are more and more patients with hyperlipidemia and hyperproteinemia, and the patient population is getting younger and younger. Hyperlipidemia and hyperproteinemia are a group of common clinical disorders of lipid metabolism. When the concentration of plasma lipid exceeds the upper limit of normal value, it becomes hyperlipidemia. When the lipoprotein in plasma exceeds the upper limit of normal value, it is called Hyperlipoproteinemia. Epidemiological studies have shown that increased levels of plasma low-density lipoprotein and very low-density lipoprotein are important factors for premature atherosclerosis and coronary heart disease. Statistical analysis shows that for eve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4965A61K47/36A61K47/38A61K9/20A61K9/28A61P3/06
Inventor 汪六一汪金灿肖群
Owner HAINAN WEI KANG PHARMA QIANSHAN
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