Method for preparing nanometer realgar gel and nanometer realgar with biomacromolecule template to regulate shape and particle thereof

A biomacromolecule and nano-realgar technology, which is applied in medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problems of nano-realgar that is difficult to dissolve in water, has good water solubility, and is easy to oxidize, so as to regulate the human body. Immunity function, good water solubility, not easy to oxidize

Inactive Publication Date: 2008-03-12
GUANGXI NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The nano-realgar prepared by this method has high purity, uniform particle size, adjustable size, variable shape, and good water solubility, which can solve the existing problems that the existing nano-realgar is difficult to dissolve in water, easy to oxidize, easy to agglomerate, and relatively toxic

Method used

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  • Method for preparing nanometer realgar gel and nanometer realgar with biomacromolecule template to regulate shape and particle thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of nano-realgar colloid and nano-realgar with serum albumin as a biomacromolecular template:

[0047] According to Fig. 1 process flow step, the filtrate that I~V makes, under N Protection, add the hydrochloric acid that concentration is 0.1~1M, adjust pH3~7, under violent stirring, add concentration and be 10 -5 mol L -1 The serum albumin (protein) solution, its weight part is 40~70 times of nanometer realgar weight part, aging 1~6 hour, makes the nanometer realgar colloid with serum albumin as template. Wherein, the nano-realgar is approximately spherical and has a particle diameter of 1-20 nm. The above-mentioned nano-realgar colloid is further vacuum-dried to obtain the nano-realgar with serum albumin as a template.

Embodiment 2

[0048]Embodiment 2 takes sodium carboxymethyl cellulose as the nano-realgar colloid and nano-realgar prepared by the biomacromolecular template:

[0049] According to the process step described in Example 1, adding concentration is 0.1~0.5% carboxymethyl cellulose sodium (biological polysaccharides), its weight part is 30~50 times of nanometer realgar weight part, aging, obtains carboxymethyl cellulose Nano-realgar colloid with cellulose sodium as template. Nano-realgar with different sizes can be obtained by changing the aging time. After aging for 1 hour to 10 days, dendritic nano-realgar with a particle size of 10-100nm can be obtained; after aging for 11-60 days, dendrites with a particle size of 100nm-5μm can be obtained. Nano-realgar, the above-mentioned nano-realgar colloid is further vacuum-dried to obtain nano-realgar with sodium carboxymethyl cellulose as a template.

Embodiment 3

[0050] Example 3 Preparation of nano-realgar colloid and nano-realgar with polyvinylpyrrolidone as a biomacromolecular template:

[0051] According to the process step described in Example 1, adding concentration is 0.1~0.6% polyvinylpyrrolidone (macromolecular compound), its weight part is 10~40 times of nanometer realgar weight part, aging 1~12 hours, obtains polyethylene Pyrrolidone as template nano realgar colloid. Wherein, the nano-realgar is approximately spherical and has a particle diameter of 10-80 nm. The above-mentioned nano-realgar colloid is further vacuum-dried to obtain the nano-realgar with polyvinylpyrrolidone as a template.

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Abstract

This invention supplies a method for preparing nanorealgar colloid and nanorealgar through modulating their appearance and particle size with biology macromolecular mold. Its characteristic is: chemically remove arsenic and impurity elements from natural realgar mine, make nanorealgar colloid and nanorealgar by taking biology macromolecular as mold to modulate the appearance and particle size, so nanorealgars of various appearance and particle size can be prepared by changing mold varieties and ageing conditions. This invention has broad processing raw materials, and the yielded nanorealgar has high purity, uniform particle size, good water-solubility, it is uneasy to oxidation or reunion and has obverse synergism effect with mold molecule. It can markedly strengthen the effect of realgar antibiosis and anti-tumour, improve realgar biology availability, depress realgar toxic side effect and expand realgar route of administration.

Description

(1) Technical field: [0001] The invention relates to a preparation method of traditional Chinese medicine nano-realgar, in particular to a method for preparing nano-realgar colloid and nano-realgar by using a biomacromolecular template to control the morphology and particle size. (two) background technology: [0002] Realgar, as a mineral traditional Chinese medicine, has been recorded in my country's first monograph on medicine, "Shen Nong's Herbal Classic". It has been used to treat scabies, malignant sores and snake bites for a long time. Since the 1950s, Chinese scholars have taken the lead in using realgar-containing compound preparations or the original drug realgar for clinical treatment of tumors in the blood system and other parts of the human body, with a high safety and remission rate. However, realgar, as an arsenic-containing compound, has a biphasic effect on the body. While killing cancer cells and bacteria, it also exhibits toxicity. It can inhibit the activ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K16/06A61K9/00A61K33/36A61K9/14A61P31/04A61P35/00
Inventor 沈星灿梁宏陈韵郭艳芳韦静
Owner GUANGXI NORMAL UNIV
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