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Pharmaceutical composition for treating acute kidney failure

A technology for acute renal failure and composition, applied in the field of compositions for the treatment of acute renal failure, can solve the problems such as the unexplained mechanism of amino acid protection, and achieve the effect of affordable price and rich sources

Inactive Publication Date: 2008-04-30
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mechanism of the protective effect of amino acids on renal function has not been elucidated

Method used

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  • Pharmaceutical composition for treating acute kidney failure
  • Pharmaceutical composition for treating acute kidney failure
  • Pharmaceutical composition for treating acute kidney failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of Xiangdan Injection: Weigh 10g of Salvia miltiorrhiza and 10g of Jiangxiang, decoct the salvia miltiorrhiza in water, concentrate the water to a relative density of 1.04-1.06, then cool it to about 50 degrees, add a certain amount of gelatin solution until no precipitation occurs When the supernatant is concentrated to a relative density of 1.15-1.17, add ethanol up to 50-60%, then stand at room temperature and filter, the filtrate recovers the concentrated solution after ethanol, and dilutes to 1ml with water for injection. Salvia miltiorrhiza crude drug 1-3g, after filtering, adjust pH to acidity, extract with equal amount of ethyl acetate several times, combine ethyl acetate extract, recover ethyl acetate, obtain salvianolic acid extract extract, dilute with water for injection to the equivalent of 3g of the crude drug containing Danshen, add several times the amount of water for injection, let it stand at room temperature, filter to remove the precipita...

Embodiment 2

[0039] Weigh 1g of glycine, 10g of salvia miltiorrhiza, 10g of radix radix, and 80g of normal saline; with reference to the method of Example 1, first make radix radix radix radix radix radix 20% concentration into Xiangdan injection, take 20ml of 20% Xiangdan injection, and then The composition of the present invention is formulated with glycine and physiological saline.

Embodiment 3

[0041] Take by weighing 0.5g of glycine, 10g of salvia miltiorrhiza, 10g of radix radix, and 80g of normal saline; with reference to the method of Example 1, it is 20% Xiangdan injection that Danshen root is made into radix radix, and 20ml of 20% radix radix is ​​taken, Then prepare the composition of the present invention with glycine and physiological saline.

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Abstract

The invention discloses a pharmaceutical composition for treating acute kidney failure, which comprises (by weight ratio) 10.0-25.0 of Xiangdan injection, 1.0-5.0 of glycine, and 70.0-88.0 of physiological saline solution. The composition can be prepared into various dosage forms including injection, powder preparation, tablet, and capsule.

Description

technical field [0001] The invention relates to a composition for treating acute renal failure, in particular to the use of the composition for treating acute renal failure in the field of pharmacy. Background technique [0002] In clinical practice, it is common for patients to develop acute ischemic renal dysfunction due to trauma, shock, and major surgery. The renal excretory function of the patient decreased rapidly in a short period of time, the glomerular filtration function dropped below 50% of the normal value, the blood creatinine and blood urea nitrogen levels rose rapidly and caused water, electrolyte and acid-base balance disorders and acute uremia symptoms. Although the incidence rate of acute renal failure is low, the case fatality rate is still as high as 49%-71%. How to reduce and prevent acute renal failure has always been the main research topic for people to protect kidney damage. [0003] In recent years, there are more and more reports on the applicati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K36/48A61K31/195A61K9/10A61K9/14A61K9/20A61K9/48A61P13/12
Inventor 谢立平
Owner ZHEJIANG UNIV
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