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Medicine used in medical breath diagnosis

A drug and medical technology, applied in the field of medical diagnosis, can solve the problems of long preparation cycle, difficulty in popularization, and high cost, and achieve the effect of shortening the preparation cycle and reducing production cost

Inactive Publication Date: 2008-07-16
SHENZHEN SEEKYA BIO SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology adopts the abundance of 99% 13 C isotope-labeled drugs have a long preparation period and high cost, which makes this breath test too expensive and difficult to popularize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Using the compound as 13 C-urea, the abundance is 58%, and the breath test is performed at the same time as the traditional 99% abundance product, with the same diagnostic accuracy, the compound is adopted 13 Carbon monoxide with a C abundance of 58% is synthesized as a raw material. The raw material is obtained from the middle of the traditional low-temperature distillation preparation process, and can also be obtained through a combined technology of electromagnetic separation and chromatographic separation. In this way, its preparation cost will be much lower than that by making the abundance 99% 13 C-urea was diluted to obtain 58% 13 The cost required for the equivalent drug of C abundance, because the cost of preparing 99% and above abundance compounds is extremely expensive. Furthermore, the above-mentioned drugs can be made into capsules, and batches of capsules can be packaged in bags. Those who need a breath test can just take out the capsules and take them, ...

Embodiment 2

[0016] Using the compound as 13 C-aminopyrine, with an abundance of 95%, has been tested to be consistent with the diagnostic results of traditional 99% abundance products, because the raw materials used in this drug are 95% abundance 13 C-compound (this compound can be carbon monoxide, carbon dioxide, barium carbonate, etc.), is obtained by using electromagnetic separation and chromatographic separation combined technology, and can also be obtained in the middle of the traditional low-temperature distillation preparation process, so the cost is much lower than that obtained by will be ready 13 C abundance 99% 13 C-aminopyrine was diluted to obtain an abundance of 95% 13 The cost of C-aminopyrine. The above-mentioned medicines are made into tablets, and then the batch medicines of the tablets are packed in bottles, and when the breath test is performed, a few tablets are taken out and taken.

Embodiment 3

[0018] The compounds and their molecular formulas used successively are as follows, and the parentheses are 13 The specific position of the C mark: 1, 13 C-urea[ 13 C-Urea]

[0019] 3. 13 C-aminopyrine [Aminopyrine (n, n-dimethyl- 13 C)]

[0020] 4. 13 C-methacetin [Methacetin (methoxy- 13 C)]

[0021] 5. 13 C-Phenacetin (ethoxy-1- 13 C)]

[0022] 6. 13 C-erythromycin[ 13 C-Erythromycin]

[0023] 7. 13 C-Phenylalanine[ 13 C-Phenylalanine]

[0024] 8, 13 C-glycerol trioleate [Triolein (1,1,1- 13 C)]

[0025] 9, 13 C-glycerol tricaprylate [Trioctanoin (1,1,1- 13 C)]

[0026] 10. 13 C-corn starch[ 13 C-Maize Starch]

[0027] 11. 13 C-corn oil[ 13 C-Maize Oil]

[0028] 12. 13 C-Triglycerides (mixed) [ 13 C-Triglycerides (mixed)]

[0029] 13. 13 C-tripalmitin[ 13 C-Tripalmitin]

[0030] 14. 13 C-xylose or 13 C-pentose [D-Xylose (1- 13 C)]

[0031] 15. 13 C-sucrose[ 13 C-Sucrose]

[0032] 16. 13 C-Lactose[ 13 C-Lactose]

[0033] 17. 13 C-a...

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PUM

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Abstract

A medicine for medical expiration diagnosis includes 13C marker compound, and features that the richness of 13C at one marked position is 50-95%. As it is prepared from the compound whose richness of 13C is lower, it has short preparing period and low cost.

Description

technical field [0001] The invention relates to medical diagnosis technology, in particular to medicines for medical breath diagnosis. Background technique [0002] Using stable isotope tracer technology to achieve medical diagnosis through breath test has been increasingly accepted by doctors and patients. The existing technology adopts the abundance of 99% 13 C isotope-labeled drugs have a long preparation cycle and high cost, which makes this breath test too expensive and difficult to popularize. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a novel drug for medical breath diagnosis, which has a short production cycle and low preparation cost, and can ensure the accuracy of medical breath diagnosis. [0004] The above-mentioned technical problem of the present invention is solved like this, constructs a kind of medicine that is used for medical exhalation diagnosis, comprises making certain dosage form 13...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K51/00
Inventor 马永健
Owner SHENZHEN SEEKYA BIO SCI & TECH CO LTD