Meso-porous nanometer particle of calcium phosphate, preparation method and application thereof
A mesoporous calcium phosphate and nanoparticle technology, applied in the field of nanomaterials, can solve the problems of poor biodegradability and biological activity, difficult to identify mononuclear phagocytes, and reduce the content of drugs in other tissues, achieving low prices and abundant sources of drugs. , the effect of high drug loading
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Embodiment 1
[0030] Weigh 14g of dodecyl phosphate and dissolve in the mixed solution of 30ml deionized water and 30ml ethanol, add 15ml 0.5mol·L -1 Ca 2+ solution and 15ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 2mol·L -1 NaOH solution to adjust the pH value to 10, and then evaporate and reflux at 90°C for 24 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:
[0031] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , Dodecyl Phosphate 0.88mol L -1 .
[0032] TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 40-100 nm and a length of 5-10 μm (Fig. 1(a), Fig. 1(b)). The pores are evenly distributed, which is conducive to drug loading. The specific surface area is 160m 2 g -1 , with an average pore size of 3.5nm ( Figure 4 ), the pore volume is 0.21cm 3 g -1 . XRD...
Embodiment 2
[0035] Weigh 12g of cetyl phosphate and dissolve it in a mixed solution of 20ml deionized water and 20ml ethanol, and add 10ml of 0.5mol·L -1 Ca 2- solution and 10ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 3mol·L -1 NaOH solution to adjust the pH value to 8, and then evaporate and reflux at 100°C for 12 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:
[0036] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , cetyl phosphate ester 0.93mol L -1 .
[0037] The specific surface area of the obtained mesoporous calcium phosphate nanopowder is 210m 2 g -1 , the pore volume is 0.23cm 3 g -1 , the average pore size is 5.2nm.
[0038] The TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 90-120nm and a length of 6-8μm, and the pores are evenly distributed, ...
Embodiment 3
[0040] Weigh 16g of octadecyl phosphate and dissolve it in a mixed solution of 25ml deionized water and 25ml ethanol, and add 12ml of 0.5mol·L -1 Ca 2+ solution and 12ml0.3mol·L -1 PO 4 3- solution, after mixing evenly, use 4mol·L -1 NaOH solution to adjust the pH value to 9, and then evaporate and reflux at 110° C. for 36 hours to obtain a white precipitate, then wash the reaction product with methanol, and dry to obtain a mesoporous calcium phosphate nanopowder. Wherein the molar concentration of above-mentioned each component is:
[0041] Ca 2+ Ion 0.5mol L -1 、PO 4 3- Ion 0.3mol L -1 , Octadecyl Phosphate 0.91mol·L -1 .
[0042] The specific surface area of the obtained mesoporous calcium phosphate nanopowder is 240m 2 g -1 , with a pore volume of 0.25 cm 3 g -1 , with an average pore size of 7.5nm.
[0043] The TEM photos show that the particles are in the shape of nanoribbons with a bandwidth of 100-120nm and a length of 8-7μm. The pores are evenly dist...
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