Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Production of milbemycin and milbeoxime microemusifier, water emusifier and suspending agent

A technology of mirbemycin and mirbeoxime, which is applied in the field of preparation of mirbemycin and mirbeoxime insecticidal microemulsion, water emulsion and suspension agent, can solve problems such as breaking the boundary of physical property requirements of active substances and the like

Inactive Publication Date: 2009-05-27
NORTHEAST AGRICULTURAL UNIVERSITY
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the actual situation, the physical property requirements of the above-mentioned dosage forms for active substances seem to be broken

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Production of milbemycin and milbeoxime microemusifier, water emusifier and suspending agent
  • Production of milbemycin and milbeoxime microemusifier, water emusifier and suspending agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 1.0% milbemycin and milbemycin microemulsion:

[0040] Get milbemycin or milbemycin 2g (the average active ingredient of milbemycin or milbemycin is 50%), dissolve with 7g xylene and 7g ethyl acetate, then add benzylphenol polyoxyethylene polyoxypropylene Base ether, calcium dodecylbenzenesulfonate mixed emulsifier 18g, azone 1g, ethylene glycol 1g, add 1g sodium lauryl sulfate, heat to 40-50°C and stir to dissolve, then add measured 60g water into it , vigorously stirred evenly, maintained for 15-20 minutes, and then returned to room temperature to obtain 100g of 1.0% milbemycin and milbemycin microemulsion.

Embodiment 2

[0041] Embodiment 2 10% milbemycin and milbemycin aqueous emulsion:

[0042] Recipe: milbemycin or milbemycin 20g (the average active ingredient of milbemycin or milbexime is 50%), 17g ethyl acetate, 23 acetone, phenethylphenol polyoxyethylene ether formaldehyde condensate and benzyl Phenolic polyoxyethylene polyoxypropylene ether mixed emulsifier 11g, polyvinyl alcohol 1g, propylene glycol 1g, defoamer 1g, water 26g.

[0043] preparation steps

[0044] 1. Put 17g of ethyl acetate and 23g of acetone into the reactor and mix evenly, add 20g of milbemycin, and keep stirring until the milbemycin or milbemycin is completely dissolved in it, and make an oil for later use.

[0045] 2. Put 26g of water into the reactor, then add benzylphenol polyoxyethylene polyoxypropylene ether and styrene ethylphenol polyoxyethylene ether formaldehyde condensate mixed emulsifier, polyvinyl alcohol, propylene glycol, defoamer Stir continuously until the substances are completely dissolved to form...

Embodiment 3

[0047] Example 3 5.0% milbemycin and milbemycin suspension concentrate:

[0048] Grind 10g of milbemycin or milbemycin (the average active ingredient of milbemycin or milbemycin is 50%) to below 300 microns, mix with 3g of alkyl polyoxyethylene ether formaldehyde condensate and 4g of Tween-80 , use a colloid mill to homogenize and grind the solid particles to about 40 microns, add 5 g of water, further pulverize and homogenize with a high-speed shear emulsifier, and then grind to a solid particle of 0.5-2 microns by a sand mill, take out the ground material, and add two 1.0 g of sodium butylnaphthalene sulfonate and 8 g of ethylene glycol were homogenized with a high-speed shear emulsifier, and 0.3% xanthan gum solution was added to 100 ml during homogenization, and homogenized for 50 minutes to obtain a suspension.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention is concerned with the preparation method of the milbemycins, the milbeoxime Microemulsion, the EW and the WP. The milbemycins and the milbeoxime is 16-membered ring macrolide that is high control efficiency for different kinds of acarid. The feature is: high effect, small medicine use, and innocuity for human; the Microemulsion, the EW and the WP is not pollution for environment. The milbemycins and the milbeoxime combine with the non-polluted pesticides that are the non-environmental pollution preparation.

Description

technical field [0001] The invention belongs to the field of preparation of new formulations of pesticides, and in particular relates to a preparation method of milbemycin and milbemycin insecticidal microemulsions, emulsions in water and suspensions for agricultural plant protection. Background technique [0002] Microemulsions, aqueous emulsions, and suspensions are all based on water, but there are essential differences in the processing methods among the three. Generally speaking, microemulsion is a thermodynamically stable system, the particle size of the emulsion is extremely small (0.01-0.1 μm), and it is a transparent or translucent dispersion system that is stable over time. The amount of emulsifier is generally more than twice that of the active substance, and a certain amount of organic solvent and solubilizer is required. Active substances that can be processed into water emulsions can theoretically be processed into microemulsions, but the processing concentrat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/04A01P7/02A01P7/04
Inventor 向文胜高爱丽王相晶
Owner NORTHEAST AGRICULTURAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com