Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process for producing kuh-seng total flavone and flavone salt by kuh-seng

A technology of total flavonoids of Sophora flavescens and alkaloids of Sophora flavescens is applied in the directions of antitoxins, antitumor drugs, organic chemistry, etc. to achieve the effects of increasing lipophilicity, low cost of raw materials, and strong antimicrobial activity.

Inactive Publication Date: 2009-08-19
SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Flavonoid salt products have the biological activity of flavonoids, relatively stable chemical properties, can be compatible with alkaline drugs, and are easy to store. There are no reports about their products or production processes.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 〔1〕Add 100g of Sophora flavescens powder of 10-40 meshes to 300ml of methanol, extract by ultrasonic vibration for 30min, stand still, filter, wash the filter cake with methanol until it is colorless and free of alkaloids; filter, concentrate the filtrate to 100ml, add 400ml of water, flavonoids Substances were precipitated and filtered.

[0034] [2] Distilled under reduced pressure to obtain a yellow powder product, which contains 80% (UV) of total flavonoids after testing.

Embodiment 2

[0036] [1] Add 100g of 40-80 mesh flavescens powder to 300ml of ethanol-ammonia solution, alcohol:ammonia = 100:0.2 (ml / ml), percolate until the extract is colorless and free of alkaloids, concentrate the extract to 100ml, add 400ml of water, flavonoids precipitated, filtered.

[0037] [2] Spray drying to obtain a yellow powder product, which contains 82% (UV) of total flavonoids after testing.

Embodiment 3

[0039] [1] Add 100g of Sophora flavescens powder of 80-100 meshes to 300ml of ethanol-hydrochloric acid (10%) solution, alcohol: hydrochloric acid = 100:1 (ml / ml), stand for extraction, filter, and repeat the extraction of the filter cake until the extract is colorless And without alkaloids, the extracts were combined and concentrated to 100ml, added with 600ml of water, flavonoids were precipitated, and filtered.

[0040] [2] Freeze-dry the flavonoid-enriched phase to obtain a yellow powder product, which contains 85% (UV) of total flavonoids after testing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A method for producing total flavonoids of Sophora flavescens is to mix 10-120 mesh Sophora flavescens and solvent in proportion, the mixing ratio is: the quality of Sophora flavescens: the volume of solvent or solution=1g: 3-10ml, extract the Sophora flavescens alkaloids and total flavonoids of Sophora flavescens, after filtration, the extract can be treated to completely separate the alkaloids of Sophora flavescens and total flavonoids of Sophora flavescens, and the enriched phase of total flavonoids of Sophora flavescens is dried to obtain total Products of flavonoid salts. The invention has the functions of separately extracting Sophora flavescens alkaloids and Sophora flavescens flavonoids, has low raw material cost, simple process and is suitable for industrial production. The obtained Sophora flavescens total flavonoids and its salt products have the advantage of higher content.

Description

technical field [0001] The invention relates to a method for producing total flavonoids or flavone salts of Sophora flavescens. technical background [0002] Flavonoids are a class of natural products that widely exist in nature, and their basic core is 2-phenylchromones, which refer to two benzene rings (A, B rings) with phenolic hydroxyl groups connected to each other through the central three carbon atoms. A series of compounds can be divided into flavonoids, flavonols, dihydroflavones, dihydroflavonols, anthocyanins, chalcones, and dihydrochalcones according to the difference of the central 3-carbon chain. , isoflavones, dihydroisoflavones, etc. Experiments have proved that flavonoids have the following effects on animals and humans: ① anti-oxidation and scavenging free radicals; ② synergistic effect on vitamin C; Damaged by carcinogens, inhibiting tumor cell proliferation and anti-free radicals, it has anti-cancer effects; ④ can chelate with metals, protect the activit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/04C07D311/30C07D311/32C07D311/36C07D311/38C07D311/62A61P39/00A61P39/06A61P35/00
Inventor 侯相林刘鹏飞邓天昇
Owner SHANXI INST OF COAL CHEM CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com