Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch

An ultrasonic microbubble and contrast agent technology, applied in echo/ultrasonic imaging agent and other directions, can solve the problem of not being able to meet industrialized mass production, and achieve the effect of stable performance and good imaging effect.

Inactive Publication Date: 2009-09-09
郑元义 +1
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Problems solved by technology

[0003] At present, the preparation technology of ultrasonic microbubble contrast agent in China mainly adopts the preparation technology of acoustic vibration method, but the research of ultrasonic microbubble preparation using this technology is still limited in the laboratory, mainly because the preparation technology of ultrasonic microbubble method cannot meet the requirements of industrialization. mass production requirements

Method used

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  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch
  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch
  • Emulsion spray drying method for preparing ultrasound microbubble contrast agent in batch

Examples

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Embodiment 1

[0021] Embodiment 1: Preparation of liposome ultrasonic microbubble contrast agent

[0022] Reagents: Phosphatidylcholine, perfluorohexane, broshamer 188, and hydroxyethyl starch were all purchased from Chongqing Pharmaceutical Company.

[0023] Equipment: high-pressure homogenizer, agitator, spray dryer, blood cell counter, etc. are conventional equipment in this field.

[0024] Method: Dissolve 3g of phosphatidylcholine and 0.8g of boroxamer 188 in 250g of double-distilled water, and add 18ml of perfluorohexane liquid while stirring to obtain liquid fluorocarbon lipid colostrum. The homogenizer makes a homogeneous emulsion. After mixing the emulsion with an equal amount of physiological saline solution containing 8% hydroxyethyl starch, the liposome microbubbles are prepared by spray drying. After the microbubbles were placed in a vacuum environment (pressure lower than 2torr) for about 1 hour, a mixed gas of fluorocarbon and nitrogen was introduced until the air pressure ...

Embodiment 2

[0025] Embodiment 2: Preparation of carbohydrate ultrasonic microbubble contrast agent

[0026] Reagents: Sugar esters, perfluorohexane, polyether, and hydroxyethyl starch were all purchased from Chongqing Pharmaceutical Company.

[0027] Equipment: high-pressure homogenizer, agitator, spray dryer, blood cell counter, etc. are common equipment in this field.

[0028] Method: Dissolve 13g sugar ester in 1.5L double-distilled water, add 100ml perfluorohexane liquid while stirring to obtain liquid fluorocarbon colostrum, and pass this colostrum through a high-pressure homogenizer to obtain a uniform emulsion. Then the emulsion is mixed with an equal amount of physiological saline solution containing 8% hydroxyethyl starch, and the liposome microbubbles are prepared by a spray-drying method. After the microbubbles were placed in a vacuum environment (pressure lower than 2torr) for about 1 hour, a mixed gas of fluorocarbon and nitrogen was introduced until the air pressure was bal...

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Abstract

The invention relates to a method for preparing an ultrasonic microbubble contrast agent, in particular to a method for preparing an ultrasonic microbubble contrast agent in batches by using an O / W emulsification solvent evaporation method and a spray drying method, comprising the following steps: (a) dissolving the ester in water, stirring Adding perfluorohexane liquid to obtain liquid fluorocarbon colostrum; (b) homogenizing the obtained colostrum to obtain a uniform emulsion; (c) mixing the obtained emulsion with an equivalent amount of 6-10% hydroxyethyl starch Compatibility solutions are mixed, and liposome microbubbles are prepared by spray drying; and (d) after the microbubbles are placed in a vacuum environment for about 1 hour, a mixed gas of fluorocarbon and nitrogen is introduced until the air pressure is balanced with the atmospheric pressure, and after sterilization, the Stable ultrasound microbubble contrast agent. The invention also relates to the ultrasonic contrast agent produced by the above method, including liposome ultrasonic contrast agent and carbohydrate ultrasonic contrast agent. The produced ultrasonic contrast agent is safe, stable and has good imaging effect.

Description

technical field [0001] The invention relates to a method for preparing an ultrasonic microbubble contrast agent, in particular to a method for batch-preparing an ultrasonic microbubble contrast agent by adopting an O / W emulsification solvent evaporation method and a spray drying method. Background technique [0002] Ultrasonic microbubble contrast agent, as a new type of acoustic contrast agent, has played a huge role in the ultrasound imaging of organs and tissues. With the development of ultrasonic technology and the improvement of contrast agent preparation technology, ultrasonic microbubbles will have a broader application prospect. [0003] At present, the preparation technology of ultrasonic microbubble contrast agent in China mainly adopts the preparation technology of acoustic vibration method, but the research of ultrasonic microbubble preparation using this technology is still limited in the laboratory, mainly because the preparation technology of ultrasonic microb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 郑元义王志刚冉海涛许川山张群霞凌智瑜杨春江李兴开
Owner 郑元义
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