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Moistureproof coating method of Xiaojianzhong capsule

A coating and capsule technology, used in capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as loss, inability to guarantee the health rights of patients, and enterprise adjustment and elimination, and achieve stable filling and moisture-proof. Good effect, the effect of slowing down the rate of moisture absorption

Active Publication Date: 2009-10-21
贵州太和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that if the above measures are taken, even if they do not absorb moisture during the production process, they will still absorb moisture and agglomerate for a long time after being marketed, and become an inferior drug. Not only cannot the health rights of patients be guaranteed, but also the company will face adjustments Document number, the predicament of suffering huge losses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Moisture-proof coating method of the present invention, comprises the steps:

[0015] (1) Take the following raw materials by weighing the national drug standard formula

[0016] Guizhi 235.6kg, white peony root 471.2kg, roasted licorice 157kg, ginger 235.6kg, jujube 235.6kg;

[0017] (2) Extract volatile oil from cassia twigs with steam distillation, decoct medicinal dregs, licorice, and jujube twice, combine the decoctions for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.25 (60°C), and vacuum dry ( 80°C, -0.08Mpa) the dry paste was crushed into 80-mesh powder, and about 65kg of dry paste powder was obtained for later use;

[0018] Radix Paeoniae Alba and Ginger were extracted with 50% ethanol under reflux for 2 hours, and the ethanol was recovered from the extract and concentrated to about 50L of clear paste with a relative density of 1.12-1.15 (20°C);

[0019] (3) Granulation: Put the dry cream powder in a one-step granulator, spra...

Embodiment 2

[0023] Moisture-proof coating method of the present invention, comprises the steps:

[0024] (1) Take the following raw materials by weighing the national drug standard formula

[0025] Guizhi 235.6kg, white peony root 471.2kg, roasted licorice 157kg, ginger 235.6kg, jujube 235.6kg;

[0026] (2) Extract volatile oil from cassia twigs with steam distillation, decoct medicinal dregs, licorice, and jujube twice, combine the decoctions for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.25 (60°C), and vacuum dry ( 80°C, -0.08Mpa) the dry paste was crushed into 80-mesh powder, and about 65kg of dry paste powder was obtained for later use;

[0027] Radix Paeoniae Alba and Ginger were extracted with 50% ethanol under reflux for 2 hours, and the ethanol was recovered from the extract and concentrated to about 50L of clear paste with a relative density of 1.12-1.15 (20°C);

[0028] (3) Granulation: Put the dry cream powder in a one-step granulator, spra...

Embodiment 3

[0032] Moisture-proof coating method of the present invention, comprises the steps:

[0033] (1) Take the following raw materials by weighing the national drug standard formula

[0034] Guizhi 235.6kg, white peony root 471.2kg, roasted licorice 157kg, ginger 235.6kg, jujube 235.6kg;

[0035] (2) Extract volatile oil from cassia twigs with steam distillation, decoct medicinal dregs, licorice, and jujube twice, combine the decoctions for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.25 (60°C), and vacuum dry ( 80°C, -0.08Mpa) the dry paste was crushed into 80-mesh powder, and about 65kg of dry paste powder was obtained for later use;

[0036] Radix Paeoniae Alba and Ginger were extracted with 50% ethanol under reflux for 2 hours, and the ethanol was recovered from the extract and concentrated to about 50L of clear paste with a relative density of 1.12-1.15 (20°C);

[0037] (3) Granulation: Put the dry cream powder in a one-step granulator, spra...

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Abstract

The invention discloses a moisture-proof coating method for Xiaojianzhong capsules, and Chinese medicine processing before granulation; then the obtained water-extracted dry cream powder is placed in a one-step granulator, and the alcohol-extracted clear cream is top-sprayed for granulation, and the control Cleaning paste flow rate, air inlet temperature, material temperature, the average particle size of the prepared particles is 70 mesh, and the moisture content is 2-3.9%. Coating: use hydroxypropyl methylcellulose (HPMC) or sodium polyacrylate IV as the coating The coating material is prepared into an aqueous solution with a weight percentage of 3-6%, and is coated in a one-step granulator by tangential spraying at the bottom. 3.5%, particle size is 60 mesh, moisture control ≤ 3%. After coating the granules, add the volatile oil of cassia twigs, sieve, put into capsules, and obtain. The properties of the product obtained by the method meet the requirements, and the moisture-proof effect is good. At the same time, the method can simplify the process, shorten the process time, save energy and reduce consumption, reduce material process loss, reduce product pollution, increase yield and reduce production cost.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a method for preventing moisture after particle coating. Background technique [0002] Xiaojianzhong Capsules is a traditional Chinese medicine extract powder product, and only 3.5% of excipients are allowed to be added. Since the main raw material of the product, Radix Paeoniae Alba, is extracted by alcohol extraction, its extract powder has strong hygroscopicity. The original process is to fill capsules after spray drying. Since the powder obtained by spray drying is fine and the average particle size is about 40 microns, its specific surface area is as high as 240 square meters per kilogram. As we all know, the larger the specific surface area, the higher the surface activity and the more It is easy to absorb moisture and agglomerate, and is very sensitive to moisture and heat. The direct consequences are: ①It is easy to absorb moisture during the capsule filling process, causing stic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/48A61K47/38A61K47/32A61P1/04A61P1/00
Inventor 高爱琴徐康明谢镇
Owner 贵州太和制药有限公司
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