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Pharmaceutical preparation containing zinc baicalin

A technology of baicalin zinc and baicalin, which is applied in the field of baicalin zinc pharmaceutical preparations, can solve the problems of drug loss, unsatisfactory drug efficacy and unsatisfactory effects, and achieves prolonged action time, optimal therapeutic effect, and increased bioadhesion. force effect

Inactive Publication Date: 2007-07-18
蔡传英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage form of traditional mucosal administration cannot make the drug specifically act on the lesion. The residence time of the drug in the lesion is very short, only a few minutes, and the drug is very easy to lose.
The inventor once used the new drug baicalin zinc (patent number: ZL99114810.X) obtained by himself to treat and observe the above-mentioned inflammation in the mucosal part with traditional dosage forms. Although the effect is more obvious than conventional drugs, But it is not ideal yet. It is found through observation that it is still related to the dosage form of the drug.

Method used

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  • Pharmaceutical preparation containing zinc baicalin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prepare the following preparation raw materials in parts by weight:

[0033] Sodium alginate 18 parts

[0034] Glycerin 2.4 parts

[0035] Tween-80 1.5 parts

[0036] Zinc baicalin 2.0 parts

[0037] By hand, 12.6 g of sodium alginate was added with H 2 O 100ml~150ml, heat to 85°C to make sodium alginate expand and disperse into a colloidal solution, add glycerin, Tween-80 and zinc baicalin, grind evenly, transfer to a flat glass plate after defoaming, and paint with a push rod A uniform film with a thickness of 1.0 mm is dried at 70° C., sliced, and packaged to obtain a baicalin zinc film preparation. If it is prepared by a film coating machine, it is prepared by manual operation, and the machine is used to coat the film after grinding evenly.

Embodiment 2

[0039] Prepare the following preparation raw materials in parts by weight:

[0040] Agar 10 parts

[0041] Glycerin 1.5 parts

[0042] Tween-80 3.0 parts

[0043] Baicalin zinc 1.5 parts

[0044] By hand, add H to 14.5 g of agar 2 O 120ml~150ml, heat 85℃ to make the agar expand and disperse into a colloidal solution, add glycerin, Tween-80 and baicalin zinc, grind evenly, transfer to a flat glass plate after defoaming, and use a push rod to coat it to a thickness of 0.7 mm uniform film, dried at 80°C, sliced, and packaged to obtain the baicalin zinc film preparation. If it is prepared by a film coating machine, it is prepared by manual operation, and the machine is used to coat the film after grinding evenly.

Embodiment 3

[0046] Prepare the following preparation raw materials in parts by weight:

[0047] 14 parts of hydroxyethyl cellulose

[0048] Glycerin 3.0 parts

[0049] Tween-80 4.0 parts

[0050] Zinc baicalin 3.0 parts

[0051] By hand, add H to 16.0 g of hydroxyethyl cellulose (HEC) 2 O 150ml~180ml, heat 85°C to make hydroxyethyl cellulose (HEC) expand and disperse into a colloidal solution, add glycerin, Tween-80 and baicalin zinc, grind evenly, transfer to a flat glass plate after defoaming, and use The push rod is coated into a uniform film with a thickness of 0.3 mm, dried at 90° C., sliced, and packaged to obtain the baicalin zinc film preparation. If it is prepared by a film coating machine, it is prepared by manual operation, and the machine is used to coat the film after grinding evenly.

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PUM

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Abstract

A filling baicalin-zinc medicine for killing and suppressing bacteria on skin and mucosa, relieving inflammation, and repairing mucosa tissue is proportionally prepared from viscose filming material, glycerin, tween-80, and baicalin zinc.

Description

technical field [0001] The invention belongs to the pharmaceutical dosage form for inhibiting and killing bacteria on mucous membrane and skin, anti-inflammation and repairing mucous membrane tissue, especially the film preparation of baicalin zinc medicine. Background technique [0002] Oral mucosal ulcers, nasal mucosal ulcers, ulcerative colitis, proctitis and chronic pharyngitis are common and frequently-occurring diseases. According to the survey, there are more than 300 million women of childbearing age in China, 60-70% of them (in rural areas) suffer from vaginitis and cervicitis, and 45-50% of them in cities, and the number of patients reaches about 200 million. A huge group. The health of women's reproductive tract is very important, it involves the prosperity of a nation. However, the above-mentioned mucosal diseases are currently treated with some antibacterial and anti-inflammatory drugs such as Huasu tablets, povidone-iodine, clotrimazole, etc., and the cure r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/7048A61P15/02A61P1/02A61P11/04A61P11/02
Inventor 蔡传英
Owner 蔡传英
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