Reactor

A reactor and reaction tank technology, applied in the field of reactors, can solve the problems of shortened service life, large bed pressure drop, difficulty in feeding materials and gas ventilation, etc. Wide range of effects

Active Publication Date: 2007-08-01
BIORIGHT WORLDWIDE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] As far as the packed bed reactor is concerned, the existing problems are: [1] the exchange efficiency between the substrate and the solid phase catalyst is low; [2] the reaction process is not easy to feed and gas, and it is not easy to adjust the pH value and temperature etc.; [3] Not suitable for viscous or insoluble substrates; [4] When using a solid phase catalyst with small particles, the bed pressure drop is large, which leads to easy clogging
[0007] As far as the stirred reactor is concerned, although it can adjust various reaction conditions according to needs, during the stirring process of the stirrer, since the solid phase catalyst is suspended in the substrate solution in the reaction tank, the solid phase catalyst Strong collisions will take place between the particles, between the solid-phase catalyst particles and the agitator, and between the solid-phase catalyst particles and the reaction tank wall (enzymology, edited by Chen Shigen and Zhou Runqi, Fudan University Press, Shanghai, 2001; Biological Reaction Engineering, edited by Qi Yizheng and Xia Jie, Chemical Industry Press, Beijing, 2004), which leads to the fragmentation and wear of solid-phase catalyst particles due to collisions, thereby reducing the activity of the solid-phase catalyst and shortening the service life. And the solid phase catalyst will produce fragments or slag due to fragmentation and wear, and these fragments or slag will be lost with the progress of the reaction, which will hinder the subsequent treatment of the reaction liquid, such as filtration and purification of the product, etc.
Moreover, it is well known that the greater the density and the faster the movement (rotational speed) of the solid-phase catalyst particles suspended in the solution, the higher the efficiency of the reaction; The more easily the catalyst fragments, the faster its activity declines
Therefore, the scope of application of the stirred reactor is limited, especially not suitable for solid-phase catalyst particles that are inherently fragile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0056] Example 1. Suspension agitation damages the immobilized enzyme carrier

[0057] Using the reactor shown in Figure 4, the currently widely used granular immobilized enzyme resin carrier Sepabeads EC-EP (Grazu V, Abian O, Mateo C, Batista-Viera F, Fernandez-Lafuente R, Guisan JM. Biotechnol Bioeng .2005,90:597-605; Grazu V, Abian O, Mateo C, Batista-Viera F, Fernandez-LafuenteR, Guisan JM.Biomacromolecules.2003,4:1495-1501) and granular immobilized glucose isomerase, respectively Carry out network disk stirring (that is, as mentioned above, the granular immobilized enzyme resin carrier and the immobilized glucose isomerase are respectively loaded into the container 53, and the container 53 follows the rotating shaft 21 for the stirring effect obtained by centrifugal rotation) and suspension stirring test , to compare the degree of damage to the resin carrier. Sepabeads EC-EP was purchased from Italy Resindion S.R.L company. Granular immobilized glucose isomerase was pur...

example 2

[0064] Example 2. The whole piece of open-pore immobilized cells is used as a stirring paddle for continuous stirring reaction to prepare high fructose syrup [1]

[0065] Glucose isomerase catalyzes the reaction that converts glucose into fructose. The vector pRSET-lac-MGI4-35-kan expressing glucose isomerase was prepared as follows. According to the sequence design of pGEMT-Easy (Promega), PCR primers are specifically: upstream primer RBS-NdeI: 5'-CATATGTATATCTCCTTCTTGTGTGAAATTG-3'; downstream primer RBS-AlwNI:

[0066] 5'-CAGTGGCTGCTGCCAGTGGCGATAAGTC-3'. Using pGEMT-Easy (Promega) as a template, PCR was performed with the above primers, and a 755bp product was amplified. The PCR conditions were: 50ng pGEMT-Easy (Promega), 0.4 μM RBS-NdeI, 0.4 μM RBS-AlwNI, 50 μM dATP, 50 μM dTTP, 50 μM dCTP, 50 μM dGTP, 20 mM Tris-HCl (pH 8.8), 10 mM KCl, 10 mM ( NH 4 ) 2 SO 4 , 2mM MgSO 4 , 0.1% Triton X-100, 2.5U Pfu DNA polymerase (Promega), the reaction volume was adjusted to 50 μ...

example 3

[0074] Example 3. The whole piece of open-pore immobilized cells is used as a stirring paddle for continuous stirring reaction in series to prepare high fructose syrup

[0075] The preparation of the glucose isomerase-immobilized cell sheet, the determination of its activity, its installation on the reaction tank, the operation of the isomerization reaction and the reaction tank, etc. basically refer to Example 2. In this example, 50 grams of glucose isomerase-immobilized cell sheets were prepared, and the enzyme activity was 5,298 units / gram. Adopt 2 reaction tanks as shown in Figure 4, the reaction tank I and the reaction tank II, respectively fill 23.5 grams of specific activity in the grid tray 20 with immobilized cell sheet belts of 5,298 units / gram, react separately respectively, its operation Same as example 2. When the flow rate of the reaction tank I was recorded at 7.1 g / min, the optical rotation (22°C) was -8.68 (equivalent to 48.68% fructose conversion rate); when...

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Abstract

The invention discloses a reactor which reaction media is liquid, the reactor includes at least one reaction tank, said reaction tank includes tank body and revolution axis which is installed in the tank and can rotate, said reaction tank also includes a container fixed on said axis, the whole outer wall of said container is equipped with holes which can penetrate reaction liquid and gas. The reactor provided by the invention can prevent the vitality of activator decline, extend life time of activator and has characteristics of high exchange efficiency, adequate reaction and wide application range.

Description

technical field [0001] The invention relates to a reactor, in particular to a reactor in which the reaction medium is liquid. Background technique [0002] In the fields of pharmaceutical industry, food industry, environmental protection, agriculture, light textile industry, chemical industry, etc., various reactions are often carried out by means of reactors, and most of the various reactions mentioned above require catalysts for the reaction. For reactions carried out in liquid media, in order to improve the reaction efficiency, the reactants and catalyst must be in effective contact. This is especially true when the catalyst is a solid. [0003] In the fields of biology, pharmaceutical industry, food industry, environmental protection, agriculture, etc., enzymes or enzyme-containing cells are a more attractive type of catalyst among many catalysts. Moreover, at present, enzymes or enzyme-containing cells are mostly used in immobilized forms, because immobilized enzymes / ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J8/10
Inventor 王骏金彩科
Owner BIORIGHT WORLDWIDE
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