A technology of phenylpyridine and derivatives, applied in the field of 2-phenylpyridine derivatives, can solve the problems of the inhibition of xanthine oxidase and the inhibition of uric acid synthesis, which is not disclosed or implied, and achieves strong inhibition of xanthine oxidase. Effect
Inactive Publication Date: 2007-08-01
ASTELLAS PHARMA INC
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AI-Extracted Technical Summary
Problems solved by technology
The invention provides a 2-phenylpyridine derivative or a salt thereof of formula (I). This compound has satisfying xanthine oxidase-inhibitory action and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like. The following are the sign meanings of formula (I): R<1>: H, etc; R<2>: -CO<2>H, etc; R<3> and R<4>:H, etc; R<5>: -CN, etc; R<6>: H, etc; X: -O- and -N(R<8>)- or -S-(under condition that bases indicated by R<5> and -X-R<7> combine at intervals or counterpoints compared with pyridyl); R8: H, etc; R<7>: C<1 to 8> direct or chain alkyl, etc; Y: key, etc; R<9>, R<10> and R<11>:H, etc (condition: when X equals -N(R<8>)-, R<8> and R<7> can have key merger and form nitrogen saturation heterocyclic together the adjacent nitrogen atoms.
Organic active ingredientsOrganic chemistry +9
Xanthine oxidase inhibitorNitrogen atom +9
- Experimental program(23)
- Effect test(1)
Description & Claims & Application Information
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