Method of preparing alpha-asarone

A kind of asarone, a certain amount of technology, applied in the field of preparation of organic compounds, can solve the problems of increasing production costs, difficult to complete dehydration reaction, unsuitable for industrial production, etc., to reduce raw material costs, reduce production costs, and shorten the synthesis route Effect
CN101012159AInactive Publication Date: 2007-08-08NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
Publication Date
2007-08-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a making method of antiepileptic drug alpha-asaryl, which comprises the follwoig steps: dissolving cistron-asaryl in the solvent; adding certain quantity of palladium compound as catalyst; stirring under indoor temperature or heating condition; filtering catalyst; decompressing; condensing the reacting liquid; recrystallizing residual through ligroin or skellysolve B to obtain the product.
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Description

technical field

[0001] The invention relates to a method for preparing an organic compound, more specifically to a method for preparing an antiepileptic drug α-asarone. Background technique

[0002] α-Asarone (trans-2,4,5-trimethoxy-1-propenylbenzene) has antitussive, expectorant, antiasthmatic, sedative, antispasmodic and anticonvulsant effects. It also has different degrees of inhibitory effect on the growth of pneumococcus, staphylococcus aureus and Escherichia coli. This product is low in toxicity and non-addictive, and the blood drug concentration reaches the peak after 15 minutes of administration, and is distributed in tissues and organs including the brain. The effect is outstanding, and it can be used as the first choice drug for preventing and treating epileptic seizures; intravenous infusion of asarone has good effects on the treatment of bronchial asthma and chronic bronchitis. In the application of Asarum injection in the treatment of bronchial asthma and chro...

Claims

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