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Nanometer cytochrome liposome medicine and its prepn

A technology of nano-liposome and cytochrome, which is applied in the direction of liposome delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of unstable curative effect, existence of allergies, impact on application, etc., and achieve reduction of allergies and residues Small, increased targeted effect

Inactive Publication Date: 2007-08-22
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But this medicine prepared by the prior art has two major defects, one is that the curative effect is sometimes unstable, and the other is that there is anaphylaxis
Due to the efficacy and safety considerations, the clinical application of this drug has been greatly affected.

Method used

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  • Nanometer cytochrome liposome medicine and its prepn
  • Nanometer cytochrome liposome medicine and its prepn
  • Nanometer cytochrome liposome medicine and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In the formula adopted in the present embodiment, each raw material and parts by weight thereof are as follows:

[0037] Neutral phospholipid 40;

[0038] Sitosterol 20;

[0039] Cholesterol 20;

[0040] Cytochrome C 30;

[0041] Polyethylene glycol 20;

[0042] Reduced Glutathione 10;

[0043] Vitamin C 40.

[0044] The neutral phospholipid refers to a mixture of hydrogenated soybean lecithin and cephalin in a weight ratio of 1-3:1, the sitosterol refers to β-sitosterol, and the polyethylene glycol refers to polyethylene glycol 4000.

[0045] Hydrogenated soybean lecithin is mixed with cephalin, sitosterol, and cholesterol to form the special liposome structure of the drug of the present invention. Polyethylene glycol is incorporated into liposomes to form long-circulating liposomes. Glutathione is the Antioxidant and in vivo activator of cytochrome C, vitamin C is excipient and in vitro antioxidant.

[0046] The preparation steps are as follows:

[0047] (1) D...

Embodiment 2

[0059] In the formula adopted in the present embodiment, each raw material and parts by weight thereof are as follows:

[0060] Neutral phospholipid 80;

[0061] Sitosterol 10;

[0062] Cholesterol 40;

[0063] Cytochrome C 10;

[0064] Polyethylene glycol 25;

[0065] Reduced Glutathione 5;

[0066] Vitamin C 50.

[0067] The neutral phospholipid refers to a mixture of hydrogenated soybean lecithin and cephalin in a weight ratio of 1-3:1, the sitosterol refers to β-sitosterol, and the polyethylene glycol refers to polyethylene glycol 4000.

[0068] Hydrogenated soybean lecithin is mixed with cephalin, sitosterol, and cholesterol to form the special liposome structure of the drug of the present invention. Polyethylene glycol is incorporated into liposomes to form long-circulating liposomes. Glutathione is the Antioxidant and in vivo activator of cytochrome C, vitamin C is excipient and in vitro antioxidant.

[0069] The preparation steps are as follows:

[0070] (1) Diss...

Embodiment 3

[0082] In the formula adopted in the present embodiment, each raw material and parts by weight thereof are as follows:

[0083] Neutral phospholipid 80;

[0084] Sitosterol 20;

[0085] Cholesterol 40;

[0086] Cytochrome C 30;

[0087] Polyethylene glycol 25;

[0088] Reduced Glutathione 10;

[0089] Vitamin C 50.

[0090] The neutral phospholipid refers to a mixture of hydrogenated soybean lecithin and cephalin in a weight ratio of 1-3:1, the sitosterol refers to β-sitosterol, and the polyethylene glycol refers to polyethylene glycol 4000.

[0091] Hydrogenated soybean lecithin is mixed with cephalin, sitosterol, and cholesterol to form the special liposome structure of the drug of the present invention. Polyethylene glycol is incorporated into liposomes to form long-circulating liposomes. Glutathione is the Antioxidant and in vivo activator of cytochrome C, vitamin C is excipient and in vitro antioxidant.

[0092] The preparation steps are as follows:

[0093] (1) D...

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Abstract

The present invention relates to nanometer cytochrome C liposome medicine and its preparation process. The nanometer cytochrome liposome medicine consists of neutral phosphatide 40-80 weight portions, sitosterol 10-20 weight portions, cholesterol 20-40 weight portions, cytochrome C 10-30 weight portions, polyglycol 20-25 weight portions, reductive glutathione 5-10 weight portions, and vitamin C 40-50 weight portions. The nanometer cytochrome liposome medicine is used in the first aid and auxiliary treatment of anoxia clinically.

Description

technical field [0001] The invention relates to a cytochrome C nano liposome medicine and a preparation method thereof. Background technique [0002] Cytochrome C, also known as cytochrome C, Cytochromum C, this drug is a cellular respiration activator extracted from pig heart or bovine heart, and is one of the components of the internal respiratory chain. It plays the role of transferring electrons in the internal respiratory chain. Under normal circumstances, this drug cannot penetrate the cell membrane, but when the tissue is hypoxic, the permeability of the cell membrane is enhanced, and the exogenous preparation can enter the cell through the cell membrane, thereby playing its role in correcting cellular respiration and substance metabolism. Therefore, it can be used for emergency or auxiliary treatment of various clinical hypoxia. Such as carbon monoxide poisoning, central depressant drug poisoning, neonatal asphyxia, severe shock hypoxia, dyspnea caused by anesthesi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K9/19A61K47/34A61K47/24A61K47/42A61K38/17A61P43/00A61P39/02A61K38/06A61K47/10
Inventor 蔡海德
Owner 蔡海德
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