Modified artificial bone of coral with controllable degradation rate and its preparation process

A degradation rate, artificial bone technology, applied in medical science, prosthesis, etc., can solve the problems of long-term retention in the body, difficult degradation of coral hydroxyapatite artificial bone, etc., to prevent secondary fractures, prevent degradation, and prevent permanent retention. the effect of

Inactive Publication Date: 2013-10-16
GUANGZHOU MAIBANG BIOLOGICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first purpose of the present invention is to provide a modified coral artificial bone with a controllable degradation rate in order to overcome the shortcomings of the prior art coral hydroxyapatite artificial bone that is difficult to degrade and will remain in the body for a long time after implantation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0019] The modified coral artificial bone retains the microporous structure of the original natural coral. The modified coral artificial bone is mainly composed of calcium carbonate and coral hydroxyphosphorus. It is composed of limestone, wherein the weight percentage of calcium carbonate is 30% to 70%.

[0020] In this embodiment: the main components of the natural coral are carbon, oxygen, calcium and phosphorus, wherein the content of carbon is 1% to 40%, the content of oxygen is 1% to 30%, and the content of calcium is 1% to 50%. %, the content of phosphorus is 1% to 50%. The porosity of the natural coral is 10-90%, and the pore diameter is 100-500um.

[0021] The preparation method of the present embodiment comprises the steps:

[0022] 1) Put the natural coral with a three-dimensional porous structure into the autoclave, adjust the temperature in the autoclave to 210-240°C, and the pressure to 35-55Kpa, so that the natural coral can undergo chemical reactions under th...

specific Embodiment 2

[0040] Put 1 g of pure coral hydroxyapatite standard powder into natural coral and modified coral artificial bone (calcium carbonate:calcium phosphate ratios are 2:1, 1:1, 1:2, respectively) into 20 ml of simulated body fluid for in vitro experiments In the middle, (ph value=7.4±0.2), in 37 ℃ water-bath shaker for 30 days, several samples were dried separately, the loss was measured, and the results were analyzed. The loss of modified coral artificial bone was higher than that of natural coral and pure coral. between hydroxyapatite and showed regular changes.

[0041] Test Data:

[0042] 0.03 0.02 0.02 0.02 0.01 0.01 0.01 0.01 0.01 0.01

[0043] Degradation amount

[0044] 19 19 13 15 83 98 76 73 71 45

[0045] Reaction time

[0046] 10.3 13.6

[0047] 1 3 3.38 5.36 6 7.64 17.9 24

[0048] (h)

[0049] 4 5

specific Embodiment 3

[0050] Put natural coral and modified coral artificial bone (calcium carbonate:calcium phosphate is 2:1, 1:1, 1:2, respectively) pure coral hydroxyapatite regular particles 1g into the bone defect model of the experimental dog humerus In the defect area, take out the general specimen after 12 weeks, measure the X-ray density of the defect area and the residual amount of coral components in the sample area, and analyze the results. Coral hydroxyapatite, and showed regular changes. The degradation time of the above materials is as follows: 5% degradation in 6 weeks, 30 weeks, 60 weeks, 80 weeks and 80 weeks.

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Abstract

The modified artificial coral bone with controllable degradation rate is prepared with natural coral with 3D structure as the substrate and through hydrothermal chemical reaction. The modified artificial coral bone consists of calcium carbonate in 30-70 wt% and hydroxyapatite. The preparation process of the modified artificial coral bone includes the following steps: 1.rgtg the temperature and pressure inside high pressure kettle and making natural coral change chemically to obtain the mixture of calcium carbonate and hydroxyapatite; and 2. controlling the time of chemical reaction to control the content of calcium carbonate and hydroxyapatite in the artificial bone. The present invention has controlled hydroxyapatite degrading rate for the implanted artificial bone to maintain in body for 1-2 years without permanent retention in body.

Description

technical field [0001] The invention relates to a coral artificial bone modified with a controllable degradation rate and a preparation method thereof, in particular to an artificial bone filling material requiring different degradation rates in different parts, which is suitable for application in orthopedic trauma surgery and plastic reconstruction surgery. It belongs to the field of biomedical materials. Background technique [0002] Commonly used natural coral, its main component is aragonite, and its chemical composition is calcium carbonate. Because it has a three-dimensional porous structure similar to human bones, it has been used in clinical bone defect filling, which can play a bone-conducting role. And its calcium component is the main element of bones, and the degradation products have no side effects, which appear to be good biocompatibility. However, due to the action of carbonic anhydrase in the human body, the filled corals are completely degraded when the b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/36
Inventor 张余尹庆水
Owner GUANGZHOU MAIBANG BIOLOGICAL SCI TECH
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