Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oral colon positioning feed preparation based on electric spinning superfine nuclear fibre and its making method

A technology of colon positioning and shell fiber, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve good positioning and release effects, broaden applications, and increase drug concentration.

Inactive Publication Date: 2010-10-27
SOUTHEAST UNIV
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, research in this area is focused on nanoparticles, microspheres, microcapsules, etc., but the research on oral colon-localized drug delivery preparations based on electrospun ultrafine fibers is still blank at home and abroad.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral colon positioning feed preparation based on electric spinning superfine nuclear fibre and its making method
  • Oral colon positioning feed preparation based on electric spinning superfine nuclear fibre and its making method
  • Oral colon positioning feed preparation based on electric spinning superfine nuclear fibre and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Taking 5-fluorouracil (5-FU), a drug for the treatment of colon cancer, as a model drug, a 5-FU oral colon-targeted drug delivery preparation based on electrospun ultrafine core-shell fibers was prepared.

[0061] The preparation is in the form of fiber non-woven fabric, and the fiber has a core-shell structure; 5-FU is encapsulated in the fiber core, and the auxiliary material for the shell is polyacrylic acid resin (Eudragit S100), and the auxiliary material for the core body is chitosan, polyethylene alcohol and hypromellose. Taking the content of the excipients in the fiber as the mass base, the drug loading rate is 25%.

[0062] The preparation method of the preparation:

[0063] 1.) Mix nucleosome excipients, drugs and solvents, ultrasonically oscillate or magnetically stir to obtain a nuclei solution;

[0064] 2.) Mix the excipients and the solvent for the shell, and ultrasonically oscillate or magnetically stir to obtain a shell solution;

[0065] 3.) Under the...

Embodiment 2

[0072] Using prazosin, a drug for treating hypertension, as a model drug, an oral colon-localized drug delivery preparation of prazosin based on electrospun ultrafine core-shell fibers was prepared.

[0073] The preparation is in the form of fiber non-woven fabric, and the fiber has a core-shell structure; prazosin is encapsulated in the fiber core, and the auxiliary material for the shell is cellulose acetate phthalate, and the auxiliary material for the core body is hydroxypropyl-β-ring Dextrin, alginate, hydroxymethylethylcellulose and methylcellulose. Taking the content of the excipients in the fiber as the mass base, the drug loading rate is 1%.

[0074] The preparation method of the preparation:

[0075] 1.) Mix nucleosome excipients, drugs and solvents, ultrasonically oscillate or magnetically stir to obtain a nuclei solution;

[0076] 2.) Mix the excipients and the solvent for the shell, and ultrasonically oscillate or magnetically stir to obtain a shell solution;

...

Embodiment 3

[0084] Using prazosin, a drug for treating hypertension, as a model drug, an oral colon-localized drug delivery preparation of prazosin based on electrospun ultrafine core-shell fibers was prepared.

[0085] The preparation is in the form of fiber non-woven fabric, and the fiber has a core-shell structure; prazosin is encapsulated in the fiber core, and the auxiliary material for the shell is cellulose acetate phthalate, and the auxiliary material for the core body is hydroxypropyl-β-ring Dextrin, alginate, hydroxymethylethylcellulose and methylcellulose. Taking the content of the excipients in the fiber as the mass base, the drug loading rate is 200%.

[0086] The preparation method of the preparation:

[0087] 1.) Mix nucleosome excipients, drugs and solvents, ultrasonically oscillate or magnetically stir to obtain a nuclei solution;

[0088] 2.) Mix the excipients and the solvent for the shell, and ultrasonically oscillate or magnetically stir to obtain a shell solution; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

An orally taken medicine based on electrospun superfine shell-core fibers and able to be released in colon for treating local colon disease or physiorhythmic disease is composed of the fibers consisting of the shell prepared from pH-sensitive polymer and the core prepared from the high-molecular polymer able to be specifically degraded by the unique enzyme system in colon, adhesive, and the absorption promoter, and the medicine carried by said core of fibers.

Description

technical field [0001] The invention relates to an oral colon-localized drug delivery preparation based on electrospun ultrafine core-shell fibers, which is used for oral administration of local colon diseases, circadian rhythm diseases and polypeptide protein drugs, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Modern pharmacy has entered the drug delivery system (Drug Delivery System, DDS), that is, the era of drug delivery systems. The research and application of the drug system has made it into the stage of intelligent drug delivery. The drug delivery system has made a qualitative leap in the concept of pharmaceutical preparations. Pharmaceutical preparations are no longer just a drug "recipe" with a certain dosage form, but a "device" for delivering and delivering drugs. [0003] Electrospinning is a spinning technology invented in the 1930s, and it is an effective method to obtain ultrafine fibers with diameters rangi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/36A61K47/38A61K47/40A61K9/00A61K45/00D04H13/00
Inventor 顾忠泽许茜
Owner SOUTHEAST UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com