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Method for controlling the quality of persic raw material in the plant medicine for improving hemorheology

A quality control method and fingerprint technology, which are applied in the field of quality control of the fingerprints of peach kernel raw materials in the botanical medicine for Fuzheng Huayu, can solve the problem of no peach kernel fingerprints and other problems, and achieve the effects of simple operation, strong specificity and good repeatability.

Active Publication Date: 2007-09-26
SHANGHAI HUANGHAI PHARMA
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Checking the literature published at home and abroad, only the HPLC method is used to determine the content of amygdalin in peach kernels, but there is no report on the fingerprint analysis of peach kernels

Method used

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  • Method for controlling the quality of persic raw material in the plant medicine for improving hemorheology
  • Method for controlling the quality of persic raw material in the plant medicine for improving hemorheology

Examples

Experimental program
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Embodiment 1

[0039] The peach kernels were crushed and sampled according to the quartering method. Weigh 0.500g of peach kernels, add 25ml of methanol, ultrasonically extract for 20min, take the supernatant and dilute 1 times with water, pass through a 0.22um microporous membrane, and take the filtrate for injection. The chromatographic column is an Alltima column (250*4.6mm, 5um); the mobile phase A is water, and the B phase is acetonitrile; linear gradient elution: 0-30min, 5%-46%B; flow rate 1.0ml / min; detection wavelength 210nm; column temperature 30°C; injection volume 20ul.

[0040] After determination of the fingerprint determination conditions, at least three batches of samples were measured to calculate the relevant parameters, and on this basis, the applicable parameter conditions of the high performance liquid chromatography system were proposed. That is, the chromatographic peak area reproducibility (RSD) of the amygdalin reference solution (100 μg / ml) is not higher than 3%, a...

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Abstract

The invention relates to a peach kernel fingerprint spectrum quality control method, comprising that (1), preparing peach kernel sample, (2), washing flow phase gradient, (3), building standard fingerprint spectrum that selecting the bitter apricot kernel with maximum content as index peak, (4), controlling the quality of fingerprint spectrum that a, the check peak relative holding times are that the second peak is 0.62, the fourth peak is 0.89, the fifth peak is 1.00, b, evaluating the sample quality that comparing sample HPLC fingerprint spectrum with contrast fingerprint spectrum (or contrast share mode fingerprint spectrum), while the similarity of total seven peaks should be not lower than 0.9, (5), the peach kernel collecting method. The invention can control the quality of materials to assure the stable quality of product.

Description

technical field [0001] The invention belongs to the field of quality control methods of peach kernel raw materials, in particular to a method for quality control of fingerprints of peach kernel raw materials in herbal medicines for strengthening health and removing blood stasis. Background technique [0002] Peach kernel (Semen Persicae) is derived from the seeds of Prunus persica (L.) Batsch, a plant of the Rosaceae family. It was first recorded in "Shen Nong's Materia Medica". Flat in nature, bitter in taste, sweet. Enter lung, heart, liver, large intestine four warps. It has the function of promoting blood circulation and eliminating phlegm, moistening dryness and smoothing intestines. It is often used for amenorrhea, lumps in the abdomen, blood accumulation in febrile diseases, lung stasis, intestinal epilepsy, blood stagnation, wind arthralgia, internal and external trauma and blood stasis caused by bruises, and intestinal dryness and constipation. . [0003] "Flora...

Claims

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Application Information

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IPC IPC(8): A61K36/73G01N30/02G01N30/86A61K131/00
Inventor 胡坪潘一峰
Owner SHANGHAI HUANGHAI PHARMA