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Gitamycin slow-release micro-ball preparation and its preparing process

A technology of kitasamycin and slow-release microspheres, which is applied in the improvement of the dosage form of kitasamycin premix and the invention field of the preparation process of kitasamycin slow-release microspheres, which can solve the problem of large material consumption, high cost, and large amount of dust, etc. question

Inactive Publication Date: 2007-10-03
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it is necessary to overcome the disadvantages of the above three forms of premixes, such as large amount of dust in the production process, contact with organic solvents, large material consumption, high cost, and large environmental pollution.

Method used

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  • Gitamycin slow-release micro-ball preparation and its preparing process
  • Gitamycin slow-release micro-ball preparation and its preparing process
  • Gitamycin slow-release micro-ball preparation and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037] Select 225kg of stearic acid into the chemical material tank, heat to 80°C, and stir continuously until all the auxiliary materials are melted; pump the melted stearic acid from the chemical material tank into the compounding tank, and at the same time, accurately weigh the potency of 1636μ / mg Put 100kg of kitasarmycin into the batching tank, shear and stir for 10 minutes, during which the temperature should be controlled at 80°C; import the prepared material into the storage tank, and heat the temperature to 80°C-100°C; start the conveying spray device, The materials in the storage tank are sprayed and granulated; the finished product particles are collected by sieving with a 24-mesh vibrating sieve. Finally, 313kg of the finished kitasarmycin microsphere preparation was obtained, the particle size was 250 μm-700 μm, and the yield could reach 96%.

example 2

[0039] Select 175kg of stearic acid into the chemical material tank, heat to 80°C, and stir continuously until all the auxiliary materials are melted; pump the melted stearic acid from the chemical material tank into the compounding tank, and at the same time, accurately weigh the potency of 1617μ / mg Put 80kg of kitasarmycin into the batching tank, shear and stir for 8 minutes, during which the temperature should be controlled at 80°C; import the prepared material into the storage tank, and heat the temperature to 80°C-100°C; start the feeding spray device, The materials in the storage tank are granulated through spray freezing equipment; the finished product granules are collected by sieving with a 24-60 mesh vibrating sieve. Finally, 245 kg of the finished kitasarmycin microsphere preparation is obtained, the particle size is 250 μm-700 μm, and the yield can reach 96%.

example 3

[0041] Select 220kg of calcium stearate monoglyceride into the chemical material tank, heat to 80°C, and stir continuously until all the auxiliary materials are melted; pump the melted calcium stearate monoglyceride from the chemical material tank into the batching tank, and simultaneously Weigh 100kg of kitasarmycin with a potency of 1617μ / mg into the batching tank, shear and stir for 8 minutes, during which the temperature should be controlled at 80°C; import the prepared materials into the storage tank, and heat the temperature to 80°C-100°C ℃; start the feeding and spraying device, and granulate the materials in the storage tank through the sprayer; pass the finished product granules through the cooling system and sieve through the 24-60 mesh vibrating sieve to collect. Finally, 303.5 kg of finished kitasarmycin microsphere preparations (50%) were obtained, the particle size was 250 μm-700 μm, and the yield could reach 95%.

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Abstract

A slow-release kitasamycin microball as a veterinary medicine with high effect to prevent and treat animal' s diseases, and its preparing process with high productivity are disclosed.

Description

Field of invention: [0001] The invention relates to the field of feed drug additives, and mainly relates to the improvement of the dosage form of kitasamycin premix and the invention of the preparation process of kitasamycin slow-release microspheres. Guitarmycin referred to in the present invention has another name called beilimycin, leucomycin, and leucomycin. Kitamycin microsphere preparations can also be called kitamycin microcapsule preparations. Microcapsules, referred to as microcapsules, refer to microcapsules with a diameter of 1 to 5000 μm that are formed by encapsulating solid or liquid drugs with natural or synthetic polymer materials. The preparation can be defined as kitasamycin microspheres from the appearance, and can also be called microcapsules from the internal encapsulation mechanism. Background technique: [0002] Kitamycin is an antibacterial and growth-promoting agent against Gram-positive bacteria. It is a widely used veterinary antibiotic feed addi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/52A61K9/16A61P31/04A23K20/195
CPCA61K31/7048A61K9/1617A61K9/1694A61P31/00A61P31/04
Inventor 周玉岩
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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