Nano hydrogel material and preparation method and use thereof

Abstract

This invention relates to nanometer hydrogel stuff and its preparation method. This nanometer hydrogel stuff adopt method of intercalation and reversible addition - rupture chain transfer free radical polymerization, add monomer, initiator, cross-linking agent, chain transfer agent and montmorillonite all to organic solvent system, at presence of initiator, obtain nanometer structure hydrogel stuff. This hydrogel can reach swelling balance in 2 hours; can reach de- swelling balance in 20 minutes. The swelling rate of this invention is 400 to 700 percent.

Description

technical field

[0001] The invention relates to the field of functional polymers, in particular to a nano hydrogel material with high strength and high swelling rate, its preparation method and application. Background technique

[0002] Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel has temperature sensitivity. Since Tanaka et al. discovered this characteristic in 1984, people have carried out extensive research on the theory and application of PNIPAAm hydrogel, and have It is applied in the fields of drug controlled release, enzyme immobilization and circulating absorbent.

[0003] The PNIPAAm hydrogel prepared by the traditional method has slow response rate and poor mechanical properties, which limit its application. Three methods are usually adopted to improve the response rate of hydrogels: a) Reduce the volume size of the gel, because the response time of the gel is proportional to the square of its linear size. b) Synthesize a gel with a por...

Examples

Embodiment 1

[0028] Take 1.3g N-isopropylacrylamide monomer, 0.0163g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0362g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7) 0.1325g, azobisisobutyronitrile (AIBN) 0.0245g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then vacuumize to remove the air, seal nitrogen in the flask, and react in an oil bath at 40° C. for 15 hours to carry out RAFT polymerization, thereby obtaining nanometer hydrogel materials. The hydrogels were then soaked in deionized water at 15 °C for 5 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature (20-25° C.) to obtain a dried nanometer hydrogel ma...

Embodiment 2

[0030] Take 0.2737g N-isopropylacrylamide monomer, 0.0152g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0362g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7 ) 0.1329g, azobisisobutyronitrile (AIBN) 0.0245g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then evacuate to remove the air, seal nitrogen in the flask, and react in an oil bath at 60°C for 18 hours to carry out RAFT polymerization, thereby obtaining a nanometer hydrogel material. The hydrogels were then soaked in deionized water at 5 °C for 7 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature to obtain a dry nano hydrogel material. The nanom...

Embodiment 3

[0032] Take 2.2286g N-isopropylacrylamide monomer, 0.0031g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0363g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7 ) 0.1324g, azobisisobutyronitrile (AIBN) 0.0243g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then evacuate to remove the air, seal nitrogen in the flask, and react in an oil bath at 60°C for 22.5 hours to carry out RAFT polymerization, thereby obtaining a nanometer hydrogel material. The hydrogels were then soaked in deionized water at 20 °C for 3 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature to obtain a dry nano hydrogel material. The na...

technical field

[0001] The invention relates to the field of functional polymers, in particular to a nano hydrogel material with high strength and high swelling rate, its preparation method and application. Background technique

[0002] Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel has temperature sensitivity. Since Tanaka et al. discovered this characteristic in 1984, people have carried out extensive research on the theory and application of PNIPAAm hydrogel, and have It is applied in the fields of drug controlled release, enzyme immobilization and circulating absorbent.

[0003] The PNIPAAm hydrogel prepared by the traditional method has slow response rate and poor mechanical properties, which limit its application. Three methods are usually adopted to improve the response rate of hydrogels: a) Reduce the volume size of the gel, because the response time of the gel is proportional to the square of its linear size. b) Synthesize a gel with a por...

Examples

Embodiment 1

[0028] Take 1.3g N-isopropylacrylamide monomer, 0.0163g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0362g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7) 0.1325g, azobisisobutyronitrile (AIBN) 0.0245g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then vacuumize to remove the air, seal nitrogen in the flask, and react in an oil bath at 40° C. for 15 hours to carry out RAFT polymerization, thereby obtaining nanometer hydrogel materials. The hydrogels were then soaked in deionized water at 15 °C for 5 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature (20-25° C.) to obtain a dried nanometer hydrogel ma...

Embodiment 2

[0030] Take 0.2737g N-isopropylacrylamide monomer, 0.0152g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0362g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7 ) 0.1329g, azobisisobutyronitrile (AIBN) 0.0245g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then evacuate to remove the air, seal nitrogen in the flask, and react in an oil bath at 60°C for 18 hours to carry out RAFT polymerization, thereby obtaining a nanometer hydrogel material. The hydrogels were then soaked in deionized water at 5 °C for 7 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature to obtain a dry nano hydrogel material. The nanom...

Embodiment 3

[0032] Take 2.2286g N-isopropylacrylamide monomer, 0.0031g chain transfer agent phenylethyl dithiobenzoate, crosslinking agent N, N'-methylenebisacrylamide (BIS) 0.0363g, montmorillonite (92.32wt%Mg 5.34 Li 0.66 Si 8 o 20 (OH) 4 Na 0.66 , 7.68 wt% Na 4 P 2 o 7 ) 0.1324g, azobisisobutyronitrile (AIBN) 0.0243g, and 5mL dimethyl sulfoxide were respectively added into a single-necked flask, and completely dissolved in the organic solvent dimethyl sulfoxide under the action of ultrasonic waves. Then evacuate to remove the air, seal nitrogen in the flask, and react in an oil bath at 60°C for 22.5 hours to carry out RAFT polymerization, thereby obtaining a nanometer hydrogel material. The hydrogels were then soaked in deionized water at 20 °C for 3 days with daily water changes to remove monomers and linear polymers. The hydrogel is placed in deionized water at 40° C. to make it shrink evenly, and then dried at room temperature to obtain a dry nano hydrogel material. The na...