Quickly stable complementary metal oxide semiconductor potentiostat circuit
A technology of oxide semiconductor and potentiostat, which is applied in the field of biochemical sensors, can solve problems such as the influence of signal measurement accuracy, and achieve the effect of stable current and high output impedance
Active Publication Date: 2007-11-28
INST OF ELECTRONICS CHINESE ACAD OF SCI
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[0007] According to the general complementary metal oxide semiconductor (CMOS) potentiostat structure, see Figure 1, although the sensor outputs the current signal I 0 Does not vary with point C voltage V C changes, but in the design of the subsequent readout circuit, it will be found that the sensor outputs the current signal I 0 In the case of very small (less than 3pA), when the voltage at point C V C When a sudden change occurs (high frequency of change), the current signal I 0 Will be subject to the voltage of point C V C fluctuates due to the influence of
This will have a serious impact on the measurement accuracy of weak signals of 1pA or less
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[0020] On the basis of the common potentiostat structure (Fig. 1), the present invention adds a SPDT switch K, a voltage stabilizing capacitor C 0 And a digital logic circuit 3 for controlling the state of the switch constitutes an improved complementary metal-oxide-semiconductor (CMOS) potentiostat, as shown in FIG. 3 . All of these circuit parts proposed in the invention can be integrated on a single chip through standard complementary metal oxide semiconductor (CMOS) technology and biochemical microsensors.
[0021] In the circuit of Figure 3, the bias supply V bias The positive terminal of the sensor and one electrode of the sensor are respectively connected to the positive and negative input terminals V+ and V- of the operational amplifier 1, V bias The negative end of the electrode and the other electrode share a common ground level. NMOS tube M 0 The gate is connected to the output terminal of the operational amplifier 1, the source is connected to the reverse input ...
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The invention relates to a quick stable CMOS potentiostat circuit, belonging to the biochemical sensor technology, comprising operational amplifier, bias power supply, two microelectrodes and NMOS transistors, a SPDT switch, a voltage stabilizing capacitance and a digital logic circuit controlling switch state. Whereinto, the positive end of bias power supply and a microelectrode of sensor are connected with positive and negative inputting ends of operational amplifier. The negative end of bias power supply and the other microelectrode are connected with ground level commonly. The gate of NMOS transistor is connected with the outputting end of operational end. The source cathode is connected with the negative inputting end of operational amplifier. The drain is used as the outputting end of potentiostat. One end of voltage stabilizing capacitance is connected with the ground level and the other end is connected with the SPDT switch. Two states of SPDT switch are connected with positive and negative inputting end of operational amplifier respectively. The digital logic circuit takes the charge of controlling switch direction. The invention makes the outputting end of potentiostat output a constant current source, which is closed to ideal.
Description
technical field [0001] The invention relates to the technical field of biochemical sensors, in particular to a fast and stable complementary metal oxide semiconductor (CMOS) potentiostat circuit. technical background [0002] A biochemical sensor (biochemical sensor) is a device that can sense and convert chemical quantities and biomass continuously and reversibly. The system formed has broad application prospects in life science research, biomedical engineering, medical care, food processing, environmental testing and other fields, and has attracted widespread attention. [0003] Electrochemical biosensors can directly convert biological signals into electrical signals, and are currently the mainstream in the development of miniature biochemical sensors. Among them, amperometric sensors are the most mature and widely used. Amperometric biochemical sensors generally use enzymes to study life phenomena at the molecular level, and microelectrodes are one of the important tool...
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Login to View More IPC IPC(8): G01N27/403G01N27/27G01N33/48
Inventor 杨海钢李策
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI