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Method for preparing total ginsenoside

A technology of ginseng total saponins and ginseng leaves, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of cumbersome processes, low purity of extracts, and large loss of active ingredients of ginseng and other problems, to achieve high physiological activity, easy industrial production, and high extraction and separation efficiency

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the purity of the obtained extract is not high, the process is relatively cumbersome, and the active ingredients of ginseng are lost. Therefore, it is of great significance to study more effective and high-purity extraction and separation methods of ginsenosides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take ginseng medicinal materials (roots, stems), crush them, add water and boil them to extract three times and control the pH, the first time is 6 times the amount of medicinal materials and 0.7% Na2CO3, the second time is 4 times the amount of medicinal materials and 0.3% Na2CO3 The amount of Na2CO3 in the amount of medicinal materials, the third time is 4 times the amount of water in the amount of medicinal materials; side countercurrent circulation extraction, after boiling, keep for 1.5, 1, and 1 hour respectively; the medicinal liquid is combined and cooled to room temperature, filtered, and the filtrate has been processed. Weakly basic anion D392 exchange column (Nankai University Chemical Plant), wash with 2% NaOH solution of 2 times the volume of the resin bed, discard the rinse solution; then rinse with pure water 3 times, discard the water rinse solution; use 7 times the volume of the resin bed Elute with 70% ethanol by volume, collect the eluate, concentrate ...

Embodiment 2

[0017] Take ginseng leaves, crush them, add water and ultrasonically extract four times and control the pH, the first time is 5 times the amount of medicinal materials and 0.9% NaHCO3, the second time is 4 times the amount of medicinal materials and 0.5% NaHCO3 NaHCO3, the third and fourth times are 3 times the water volume of the medicinal material; the medicinal liquid is combined and cooled to room temperature, filtered, and the macroporous weakly basic anion D380 exchange column (Nankai University Chemical Factory) that has been treated on the medicinal liquid filtrate , wash with 2.5% NaOH solution of 1.5 times the volume of the resin bed, and discard the washing solution; rinse with 4 times of pure water, discard the water washing solution; elute with 65% ethanol of 8 times the volume of the resin bed, collect the eluent, Concentrate to a thick paste (relative density is 1.28-1.33 at 50° C.), and dry with dynamic belt drying equipment to obtain total ginsenosides (total s...

Embodiment 3

[0019] Get the ginseng medicinal materials (roots, stems), pulverize, add 50% ethanol to reflux and extract three times and control the pH, the first time is 5 times the amount of 50% ethanol and Na2CO3 of the amount of medicinal materials, and the second time is the amount of Na2CO3 of the amount of medicinal materials. 4 times the amount of 50% ethanol and 0.5% Na2CO3 of the amount of medicinal materials, the third time is 4 times the amount of 50% ethanol of the amount of medicinal materials; side countercurrent circulation reflux extraction, after the start of reflux, keep 1.5, 1, 1 hour respectively; Combine the filtrates, concentrate the filtrates under reduced pressure at 70°C until there is no alcohol smell, dilute the concentrated solution with water until the medicinal material liquid ratio is 1:1.5, filter, and put the treated macroporous strong basic anion D201 exchange column on the filtrate (Nankai University Chemical Plant), rinsed with 2% NaOH solution of 2 time...

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Abstract

The invention discloses a process for preparing ginseng saponin comprising the following steps in sequence, charging dissolvent into ginseng root, rhizome or ginseng leaves, adjusting the solution to alkalinity, carrying out extraction, obtaining extract, passing the extract through macroscopic alkaline anion exchange resin, flushing with alkaline water and pure water, discarding the flushing fluid, eluting with water-containing ethanol, and concentrating the eluent.

Description

technical field [0001] The invention belongs to the preparation method of traditional Chinese medicine extract, in particular, relates to the preparation method of total ginsenosides. Background technique [0002] Ginseng is the dried root of Panax ginseng C.A.Mey, an Araliaceae plant. It is reported that ginseng contains saponins, polysaccharides, volatile oils, trace elements and other components. Among them, ginsenoside is the main active ingredient of ginseng. There are more than 30 known ginsenosides, such as Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd, Rg1, Rg2, Rg3, Re, Rh1, Rh2, Rf et al. Ginseng leaves are also rich in ginsenosides. Ginseng industrial extraction process is roughly divided into heat reflux method, cold soaking method, percolation method, water extraction and alcohol precipitation method, adsorption resin method and so on. However, the purity of the obtained extract is not high, the process is cumbersome, and the active ingredients of ginseng are lost. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K9/19A61K47/24A61K47/10A61K47/30
Inventor 杨悦武叶正良郑永锋李旭
Owner TIANJIN TASLY ZHIJIAO PHARMA
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