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Method for extracting effective part of Chinese traditional medicine of red sage root and rhizome of Sichuan lovage

A technology of effective parts and extraction methods, which is applied in the field of extraction of effective parts of the traditional Chinese medicine compound Guanxinning, can solve the problems of unstable chemical properties and discounted pharmacological activity, and achieve the effects of strong physiological activity, stable quality and low cost

Inactive Publication Date: 2007-12-26
CHIATAI QINGCHUNBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the dosage form of the compound effective part composed of Danshen and Chuanxiong is a single water injection; due to the unstable chemical properties of phenolic compounds, it is easy to decompose and deteriorate during the preparation and storage process, so the ingredients contained in the current clinical water injection It is mainly Danshensu and protocatechualdehyde with weak activity, while other salvianolic acid components with strong activity, such as salvianolic acid B and ferulic acid, are decomposed and deteriorated due to the long heating time of the process, and there are few remaining. Big discount

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Extraction of Effective Parts of Salvia Miltiorrhiza and Rhizoma Chuanxiong

[0042] Soak 5kg slices of Danshen and Chuanxiong in deionized water at 50°C for 24 hours, then extract at 60°C for 3 times, add 80L, 60L, and 60L of water respectively, and extract at 50°C under reduced pressure for 2 hours. 10L, after cooling, add 14L of 80% ethanol, let stand overnight, and filter. Ethanol is recovered from the filtrate under reduced pressure, and the resulting concentrated solution is passed through the AB-8 macroporous adsorption resin, washed with deionized water until α-naphthol reacts, and continues to be eluted with 70% ethanol until the eluent is added with ferric chloride potassium ferricyanide The reagent had no obvious phenolic hydroxyl reaction, and the eluate was concentrated under reduced pressure at 40°C to an appropriate amount, and dried under reduced pressure at 40°C to obtain 150 g of total phenolic acids of Salvia Miltiorrhiza and Rhizoma Chuanx...

Embodiment 2

[0052] Example 2: Extraction of effective parts of Salvia miltiorrhiza and Rhizoma Chuanxiong

[0053] Add 5 kg pieces of Danshen and Ligusticum chuanxiong each, add water and extract by heating at 100°C for 3 times. Add 80L of water for the first time, heat for 2 hours, add 60L of water for the second and third times, and heat for 1.5 hours respectively. The extract was depressurized at 60°C to 6.7L, and after cooling, 95% ethanol was added until the alcohol content reached 75%, left to stand overnight, and filtered. Ethanol was recovered from the filtrate under reduced pressure, concentrated under reduced pressure at 60°C to an appropriate amount, and dried under reduced pressure at 60°C to obtain 1.3Kg dry powder of total phenolic acids of Salvia Miltiorrhiza and Rhizoma Chuanxiong.

Embodiment 3

[0054] Embodiment 3: Extraction of effective parts of Salvia miltiorrhiza and Rhizoma Chuanxiong

[0055] Add 5kg slices of Danshen and Chuanxiong to reflux extraction with 70% ethanol for 3 times, add 40L of 70% ethanol for the first time, heat for 2 hours, add 30L water for the second and third times, and heat for 2 hours respectively. The extract was depressurized at 60°C to 6.7L, and after cooling, 95% ethanol was added until the alcohol content reached 75%, left to stand overnight, and filtered. Recover ethanol from the filtrate under reduced pressure, concentrate to 5L, add 95% ethanol after cooling until the alcohol content reaches 90%, let it stand overnight, filter, concentrate the filtrate to an appropriate amount under reduced pressure at 60°C, and spray dry to obtain the total phenolic acids of Salvia miltiorrhiza and Rhizoma Chuanxiong Dry powder 0.7Kg.

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Abstract

The present invention relates to an extraction method of effective components of Chinese medicine Prehexiline. The described Chinese medicine Prehexiline is made up by using composite of salvia root and ligusticum root as raw material through a certain preparation process. The extraction method of effective components of salvia root and ligusticum root includes the following steps: adding water or aqueous solution of alcohol into the decocting slices of salvia root and ligusticum root, making extraction for 1-5 times at 40-100deg.c, combining extracts so as to obtain liquid medicine, purifying said liquid medicine at 30-80 deg.C, reduced pressure concentration, drying so as to obtain the effective component extract of salvia root and ligusticum root.

Description

(1) Technical field [0001] The invention relates to a method for extracting the effective part of the traditional Chinese medicine compound Guanxinning composed of salvia miltiorrhiza and chuanxiong. (2) Background technology [0002] Salvia miltiorrhiza and Chuanxiong and various preparations containing this drug are commonly used clinical traditional Chinese medicines for treating cardiovascular and cerebrovascular diseases. Since the 1980s, clinical research has been carried out on water acupuncture made of compound prescriptions composed of Danshen and Chuanxiong. The curative effect analysis of 387 cases shows that the compound prescription composed of Danshen and Chuanxiong has a good curative effect on coronary heart disease and angina pectoris. After treatment, the effective rate of angina pectoris was 91.73%, and the effective rate of abnormal ECG was 44.39%. Cases of angina pectoris also have a good curative effect, and the symptoms of angina pectoris are generall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 吴碧元管敏文桑睿沈莹
Owner CHIATAI QINGCHUNBAO PHARMA
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