Method for preparing antiform - 4 - acetoxy - 2 - methyl - butenoic aldehyde

A technology of acetoxy and crotonaldehyde, which is applied in the preparation of pentacyclic unsaturated carbon frame compounds and the field of preparation of trans-4-acetoxy-2-methyl-2-butenal, which can solve the problem of receiving The efficiency cannot reach the yield, the process cost is increased, and the production cost is increased, so as to achieve the effects of reducing reaction steps, easy recycling, and less environmental pollution
CN101092355AInactive Publication Date: 2007-12-26GUANGZHOU WISDOM BIO TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGZHOU WISDOM BIO TECH
Publication Date
2007-12-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a method for preparing trans-4-acetoxy-2-methyl-2-crotonaldehyde. The method comprises: reacting isoprene and tert-butyl hypochlorite in acetic anhydride solution to obtain chlorine-containing ester, reacting with urotropine, and hydrolyzing to obtain trans-4-acetoxy-2-methyl-2-crotonaldehyde. The method has such advantages as few reaction procedures, easy operation, high isoprene conversion rate, high yield (40-56%), no need for DMSO during the oxidation process, no byproduct, low raw material cost, easy recovery of solvent, little environmental pollution and low cost, and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to the field of organic chemistry, in particular to a preparation method of a pentacyclic unsaturated carbon frame compound, in particular to a preparation method of trans-4-acetoxy-2-methyl-2-butenal. Background technique

[0002] Trans-4-acetoxy-2-methyl-2-butenal is a key intermediate for the artificial synthesis of vitamin A and its derivatives, and its chemical structure is . At present, the synthesis of trans-4-acetoxy-2-methyl-2-butenal by domestic manufacturers adopts the process of using acetone dimethyl acetal as the starting material. The process route is long, the yield is low, the raw materials are expensive, and the cost is relatively high. .

[0003] U.S. Patent "METHOD OF PREPARING E-4-ACETOXY-2-BUTENAL" (Patent No. 4175204) discloses a method for preparing trans-4-acetoxy-2-methyl-2-butenal, specifically using Isoprene reacts with sodium hypochlorite to generate chlorohydrins, then reacts chlorohydrins with ac...

Claims

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