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Method of preparing traditional chinese medicine formulated product for treating rheumatism paralysis

A technology of traditional Chinese medicine preparation and rheumatic arthralgia, which is applied in the field of preparation of traditional Chinese medicine preparations for treating rheumatism arthralgia, can solve the problems of low bioavailability, long dissolution time, and large dosage, so as to improve curative effect, accelerate dissolution speed, increase The effect of a large distribution area

Inactive Publication Date: 2008-01-23
TONGYAO PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug has the disadvantages of long dissolution time, slow onset of action, low bioavailability, and large dosage.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 450g of Caulis Spatholobus, 450g of Chuanshanlong, 100g of dried ginger, and 30-150g of starch for later use;

[0024] Preparation Process:

[0025] ① Grinding the dried ginger into a fine powder with a fineness of 100 mesh or crushing it into a superfine powder with a fineness of 600 mesh for later use;

[0026] ② Boil Spatholobus Spatholobus and Chuanshanlong with water twice, add 8 times the amount of water for the first 3 hours, add 6 times the amount of water for the second 2 hours, filter, combine the filtrates, and use a filter with a molecular cut-off of 10,000 Polyethersulfone membrane separation, pressure 0.3Mpa, membrane flux 2200ml / min, temperature 30°C, concentrated after separation into a clear paste with a relative density of 1.22 (measured at 25°C), for later use;

[0027] ③Mix dried ginger fine powder or superfine powder with the above clear paste, dry, crush into fine powder, pass through a 120-mesh sieve, and set aside;

[0028] 4. Add appropri...

Embodiment 2

[0030] Take 450g of Caulis Spatholobus, 450g of Chuanshanlong, 100g of dried ginger, and 30-150g of starch for later use;

[0031] Preparation Process:

[0032] ① Grinding the dried ginger into a fine powder with a fineness of 200 mesh or crushing it into a superfine powder with a fineness of 800 mesh for later use;

[0033] ② Boil Spatholobus Spatholobus and Chuanshanlong with water twice, add 6 times the amount of water for the first 3 hours, add 4 times the amount of water for the second 2 hours, filter, combine the filtrates, and use a filter with a molecular cut-off of 10,000 Polyethersulfone membrane separation, pressure 0.33Mpa, membrane flux 2700ml / min, temperature 30°C, concentrated after separation into a clear paste with a relative density of 1.26 (measured at 60°C), for later use;

[0034] ③Mix dried ginger fine powder or superfine powder with the above-mentioned clear paste, dry, pulverize into fine powder, pass through a 100-mesh sieve, and set aside;

[0035] ...

Embodiment 3

[0037] Take 450g of Caulis Spatholobus, 450g of Chuanshanlong, 100g of dried ginger, and 30-150g of starch for later use;

[0038] Preparation Process:

[0039] ① Grinding the dried ginger into a fine powder with a fineness of 100 mesh or crushing it into a superfine powder with a fineness of 700 mesh for later use;

[0040] ② Boil Spatholobus Spatholobus and Chuanshanlong with water twice, add 6 times the amount of water for the first 3 hours, add 4 times the amount of water for the second 2 hours, filter, combine the filtrates, and use a filter with a molecular cut-off of 10,000 Polyethersulfone membrane separation, pressure 0.27Mpa, membrane flux 2100ml / min, temperature 29°C, after separation, condense into a clear paste with a relative density of 1.20 (measured at 25°C), for later use;

[0041] 3. with the step of embodiment 2 3.;

[0042] ④ Add appropriate amount of starch, mix well, use water as a binder, make pellets, sieve, take concentrated pellets between 10 and 20...

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Abstract

The invention relates to a preparation method of a herbal medicine to treat rheumatoid arthralgia syndrome in the medical technology field, in particular to the modern smash, extraction and separation technology of the herbal medicine. The preparation process comprises the following steps: firstly, smash dried ginger into powder or superfine powder; secondly boil milettia reticulate and Dioscorea nipponica in water twice, then filter the mixture, merger the filter liquor and separate and purify using the membrane separation technology, and concentrate into paste; thirdly mix the dried ginger powder with the above paste and dry the mixture to smash into superfine powder; finally add accessories into the powder to make capsules, coated particles, concentrated pills or coated concentrated pills. Due to the application of the superfine smash, membrane separation, particle and pill coating technologies, the invention improves the medicine effects, enhances the medicine stability and improves the entire production quality. Medicines applied with this method boast quick solution, fast efficacy, high bioavailability and small dosage, and are very convenient for patients to take.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a preparation method of a traditional Chinese medicine preparation for treating rheumatic arthralgia. International patent classification numbers: A61K 35 / 78, A61P29 / 00. Background technique [0002] Rheumatism and rheumatoid disease are clinically common and frequently occurring diseases. Traditional Chinese medicine believes that rheumatic arthralgia is caused by exogenous evils such as wind, cold, dampness, and heat invading the human body. The main symptoms of arthralgia are pain, numbness, severe cases, or joint swelling, burning, or movement disorders. Due to the lack of righteousness, interstitial joints are not dense, exogenous evils invade, qi and blood blockages are blocked, and tendons and arteries are lost in moistening and nourishing. [0003] Traditional Chinese medicine often adopts methods in the treatment of rheumatic arthralgia, such as dispelling ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/28A61P29/00A61P19/02
Inventor 王勇王丽清刘春梅
Owner TONGYAO PHARMA GROUP CORP
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