Method of preparing traditional chinese medicine formulated product for treating rheumatism paralysis

A technology of traditional Chinese medicine preparation and rheumatic arthralgia, which is applied in the field of preparation of traditional Chinese medicine preparations for treating rheumatism arthralgia, can solve the problems of low bioavailability, long dissolution time, and large dosage, so as to improve curative effect, accelerate dissolution speed, increase The effect of a large distribution area

Inactive Publication Date: 2008-01-23

TONGYAO PHARMA GROUP CORP

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AI-Extracted Technical Summary

Problems solved by technology

However, the drug has the disadvantages of long dissolution tim...

Abstract

The invention relates to a preparation method of a herbal medicine to treat rheumatoid arthralgia syndrome in the medical technology field, in particular to the modern smash, extraction and separation technology of the herbal medicine. The preparation process comprises the following steps: firstly, smash dried ginger into powder or superfine powder; secondly boil milettia reticulate and Dioscorea nipponica in water twice, then filter the mixture, merger the filter liquor and separate and purify using the membrane separation technology, and concentrate into paste; thirdly mix the dried ginger powder with the above paste and dry the mixture to smash into superfine powder; finally add accessories into the powder to make capsules, coated particles, concentrated pills or coated concentrated pills. Due to the application of the superfine smash, membrane separation, particle and pill coating technologies, the invention improves the medicine effects, enhances the medicine stability and improves the entire production quality. Medicines applied with this method boast quick solution, fast efficacy, high bioavailability and small dosage, and are very convenient for patients to take.

Application Domain

AntipyreticAnalgesics +4

Technology Topic

Dioscorea nipponicaTraditional Chinese medicine +9

Examples

Experimental program(4)

Example Embodiment

[0022] Example 1:

[0023] Take 450g of Caulis spatholobi, 450g of Pangasius, 100g of dried ginger, and 30~150g of starch for use;

[0024] Preparation Process:

[0025] ① Crush the dried ginger powder with a fineness of 100 mesh or crush it into ultra-fine powder with a fineness of 600 mesh for use;

[0026] ②Boil Caulis spatholobi and Dioscorea nigra with water twice, the first time is 3 hours, add 8 times the amount of water, and the second time 2 hours, add 6 times the amount of water, filter, combine the filtrate, use the molecular cut-off value of 10,000 Polyethersulfone membrane separation, pressure 0.3Mpa, membrane flux 2200ml/min, temperature 30℃, after separation, it is concentrated and concentrated into a clear paste with a relative density of 1.22 (measured at 25℃) for use;

[0027] ③Mix dried ginger powder or superfine powder with the above-mentioned cleansing paste, dry, pulverize into fine powder, pass through a 120-mesh sieve, and set aside;

[0028] ④ Add appropriate amount of starch, mix well, granulate with 70% (v/v) ethanol solution, and encapsulate the granules to obtain the present invention.

Example Embodiment

[0029] Example 2:

[0030] Take 450g of Caulis spatholobi, 450g of Pangasius, 100g of dried ginger, and 30~150g of starch for use;

[0031] Preparation Process:

[0032] ① Crush the dried ginger powder with a fineness of 200 mesh or crush it into ultra-fine powder with a fineness of 800 mesh, for use;

[0033] ②Boil Caulis spatholobi and Dioscorea nigra with water twice, the first time is 3 hours, add 6 times the amount of water, and the second time 2 hours, add 4 times the amount of water, filter, combine the filtrate, use the molecular cut-off value of 10,000 Polyethersulfone membrane separation, pressure 0.33Mpa, membrane flux 2700ml/min, temperature 30℃, after separation, it is concentrated and concentrated into a clear paste with a relative density of 1.26 (measured at 60℃) for use;

[0034] ③Mix dried ginger powder or superfine powder with the above-mentioned cleansing paste, dry, pulverize into fine powder, pass through a 100-mesh sieve, and set aside;

[0035] ④ Add appropriate amount of starch, mix well, granulate with 60% (v/v) ethanol solution to obtain granules; or use hydroxypropyl methylcellulose to coat film to make coated granules to obtain the present invention.

Example Embodiment

[0036] Example 3:

[0037] Take 450g of Caulis spatholobi, 450g of Pangasius, 100g of dried ginger, and 30~150g of starch for use;

[0038] Preparation Process:

[0039] ① Crush dried ginger powder with a fineness of 100 mesh or pulverize it into superfine powder with a fineness of 700 mesh for use;

[0040] ②Boil Caulis spatholobi and Dioscorea nigra with water twice, the first time is 3 hours, add 6 times the amount of water, and the second time 2 hours, add 4 times the amount of water, filter, combine the filtrate, use the molecular cut-off value of 10,000 Polyethersulfone membrane separation, pressure 0.27Mpa, membrane flux 2100ml/min, temperature 29°C, after separation, it is concentrated into a clear paste with a relative density of 1.20 (measured at 25°C) for use;

[0041] ③Same as step ③ of Example 2;

[0042] ④ Add appropriate amount of starch, mix well, use water as a binder, make pellets, sieving, take concentrated pellets between 10-20 mesh and dry them below 60°C to obtain the present invention.

PUM

Property	Measurement	Unit
Fineness	400.0 ~ 1000.0	mesh

Description & Claims & Application Information

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