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Hydrochloric acid flunarizine dropping pills

A technology of flunarizine hydrochloride and drop pills, which is applied in the field of flunarizine hydrochloride drop pills, can solve the problems of increased contact area, increased interfacial tension, small interfacial tension, etc., and achieves the improvement of dissolution rate and dissolution rate, The effect of increasing the interfacial tension and improving the rate of qualified products

Inactive Publication Date: 2008-03-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention aims at the problems existing in the dripping head of the current dripping machine, and adopts a diameter-limited cylindrical concave nozzle dripping head to increase the contact area between the liquid medicine drop and the dripping nozzle, increase the interfacial tension, and overcome the current dripping pills. The small contact area between the dropper nozzle and the droplet of the cylindrical plane nozzle used in the machine, and the small interfacial tension lead to the problem of the difference in pellet weight and the difficulty in controlling the roundness of pellets, which can improve the rate of qualified products and reduce the weight of pellets. Dosage, at the same time, the dissolution rate and dissolution rate of the product of the present invention are significantly improved compared with flunarizine hydrochloride capsules

Method used

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  • Hydrochloric acid flunarizine dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 1 part by weight of flunarizine hydrochloride and add it to molten 15.6 parts by weight of polyethylene glycol 6000 matrix, stir well to make a uniform molten drug solution, and use a diameter-limited cylindrical concave surface under the condition of 85°C to 95°C Dropping method of dropper dripping method, cooling with simethicone oil at 40℃~-5℃, separating the oil pills, drying for 60min at a temperature of 30℃ and a relative humidity of 50%, and sieving the pellets Select pills, test, pack, and get it.

[0020] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 39%.

[0021] Get product of the present invention and flunarizine hydrochloride capsule respectively, according to dissolution assay (Chinese Pharmacopoeia version in 2005 two appendices X C second method), with hydrochloric acid solution (dilute hydrochloric acid 24ml adds water to ...

Embodiment 2

[0023] Take 1 part by weight of flunarizine hydrochloride and add it to 10 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform molten liquid, and use a diameter-limited cylindrical concave surface under the condition of 85 ° C to 95 ° C Dropping method of dropper dripping method, cooling with simethicone oil at 40℃~-5℃, separating the oil pills, drying for 60min at a temperature of 30℃ and a relative humidity of 50%, and sieving the pellets Select pills, test, pack, and get it.

[0024] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 33%.

[0025] Get product of the present invention and flunarizine hydrochloride capsule respectively, according to dissolution assay (Chinese Pharmacopoeia 2005 edition two appendix X C second method), with hydrochloric acid solution (dilute hydrochloric acid 24ml adds water to 1000ml) 60...

Embodiment 3

[0027] Add 1 part by weight of flunarizine hydrochloride into molten 5 parts by weight of polyethylene glycol 6000 matrix, stir well to make a uniform molten liquid, and use a diameter-limited cylindrical concave surface at 85°C to 95°C Dropping method of dropper dripping method, cooling with simethicone oil at 40℃~-5℃, separating the oil pills, drying for 60min at a temperature of 30℃ and a relative humidity of 50%, and sieving the pellets Select pills, test, pack, and get it.

[0028] Compared with the cylindrical plane nozzle dripper, the difference in pellet weight and qualified product rate of pellet roundness produced by the invention are increased by 41%.

[0029]Get product of the present invention and flunarizine hydrochloride capsule respectively, according to dissolution assay (Chinese Pharmacopoeia version in 2005 two appendices XC second method), with hydrochloric acid solution (dilute hydrochloric acid 24ml adds water to 1000ml) 600ml is solvent, rotating speed p...

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Abstract

The present invention relates to a kind of flunarizine hydrochloride dripping pills. It is made up by using flunarizine hydrochloride as active component, using polyethylene glycol as matrix and adopting a diameter-limited cylindrical concave orifice dripping-head dripping preparation process to produce the invented flunarizine hydrochloride dripping pills. The weight of every pill is 5mg-100mg.

Description

technical field [0001] The invention relates to flunarizine hydrochloride dripping pills, which are characterized in that they are produced by using flunarizine hydrochloride as an active ingredient, taking polyethylene glycol as a matrix, and adopting a diameter-limited cylindrical concave nozzle dripper dropping method. Dropping pills. Background technique [0002] Flunarizine hydrochloride is a selective calcium channel blocker and a selective calcium influx blocker to protect brain cells. It blocks or alleviates other ischemic injuries by antagonizing the intracellular calcium overload of the vestibulo-cochlear nucleus, and achieves brain protection and anti-vertigo effects. It can reduce the volume of cerebral infarction, reduce the degree of brain damage, inhibit the contraction of vascular smooth muscle, dilate blood vessels, increase blood flow in arterioles, and improve microcirculation. [0003] As a selective calcium ion blocker, flunarizine hydrochloride has a ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/495A61P9/10
Inventor 钱进陶琳穆正义刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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