Chlorhexidine acetate partial film forming gel composition and uses thereof
A technology of chlorhexidine acetate and gel composition, which is applied in the direction of drug combination, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of short time, affecting the therapeutic effect, and shedding, etc. Achieve the effects of good biocompatibility, easy access to raw materials, and good flexibility
Inactive Publication Date: 2010-07-07
SHANGHAI INST OF PHARMA IND CO LTD
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- Description
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- Application Information
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Problems solved by technology
However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture and fall off prematurely, so that it disappears quickly
[0007] Therefore, if adopting the technology of above-mentioned existing film-forming gel composition to prepare chlorhexidine acetate local film-forming gel, the retention time of medicament and affected part will be shorter, and affect therapeutic effect
Method used
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Embodiment 1～16
[0037] Embodiment 1~16 and comparative embodiment
[0038] The chlorhexidine acetate (do not add chlorhexidine acetate) and the esterifying agent stirring and dissolving in soluble amount respectively in embodiment 1~14 in table 1 and the chlorhexidine acetate of consumption in the comparative example (1 ' represents) In the solvent, slowly add hydroxypropyl cellulose under stirring to completely dissolve / swell, then continue to stir to form a uniform gel; then add a cross-linking agent (if necessary, add a reinforcing agent), continue to stir to make it completely uniform Supplement the solvent of remaining amount, make reach prescription quantity, stir, degassing, respectively make chlorhexidine acetate local film-forming gel composition and 100 grams of contrast film-forming gel composition not containing chlorhexidine acetate.
[0039] Table 1
[0040]
[0041]
[0042] Experimental results show that the chlorhexidine acetate local film-forming gel composition has a...
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Abstract
The present invention discloses a compound of an chlorhexidine acetate local membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent, 0.5 percentage to 5 percentage of cross linking agent,75 percentage to 90 percentage of dissolvent, 0.01 percentage to 3 percentage of chlorhexidine acetate. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is4 to 8. In the present invention, the compound of the chlorhexidine acetate local membrane forming gel is applied in the treatment of the local infection in the mucosa or the skin. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of local formulation of the chlorhexidine acetate, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has properties of long maintenance time and slow releasing of the medicine. The membrane can be effectively maintained in the skin surface for over 8 hours and the membrane can be effectively maintained on the mouth mucosa surface for over 5 hours.
Description
technical field [0001] The invention relates to a local film-forming gel composition of chlorhexidine acetate and its application in treating local infectious diseases of skin / mucosa. Background technique [0002] Chlorhexidine Acetate (Chlorhexidine Acetate) is a kind of biguanide compound, also known as chlorhexidine acetate (tai), chlorhexidine acetate, chlorhexidine acetate, etc., belonging to disinfection and antiseptic drugs. It changes the permeability of the bacterial cytoplasmic membrane to make the cell content leak out, thereby playing a bactericidal effect, and has a bactericidal effect on Staphylococcus cutaneous, Streptococcus mutans, Streptococcus salivarius, Escherichia coli, Propionibacterium and Candida albicans, etc. Both have antibacterial activity. Common chlorhexidine acetate topical preparations include solutions, gels, ointments, and sprays. However, when chlorhexidine acetate in the above dosage form is used for local sterilization and disinfection...
Claims
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IPC IPC(8): A61K31/155A61K9/00A61K9/70A61K47/10A61K47/12A61K47/38A61P17/00A61P31/04
Inventor 马晋隆陈志明
Owner SHANGHAI INST OF PHARMA IND CO LTD