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Method for preparing complex nanometer fibrous tissue renovation bracket containing collagen

A technology of composite nanofibers and collagen, which is applied in the field of preparation of composite nanofiber tissue repair scaffolds, can solve the problems that have not been reported, cannot meet the requirements of mechanical properties of tissue repair materials, and the mechanical properties of materials are low, and achieve good biological Compatibility, excellent mechanical properties, effects of high porosity

Inactive Publication Date: 2008-04-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Electrospun collagen alone has been reported, but its material mechanical properties are low, which cannot meet the mechanical properties requirements of tissue repair materials
[0004] Thermoplastic polyurethane (thermoplastic-polyurethane) has high tensile strength and elongation at break, good abrasion resistance, flex resistance, solvent resistance, hydrolysis resistance and microbial resistance, and more importantly, polyurethane has good organization Compatibility and blood compatibility make it widely used in many aspects. Polyurethane alone has also been successfully electrospun into nanofibers, but so far, electrospun collagen-polyurethane composite nanomaterials have not been reported.

Method used

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  • Method for preparing complex nanometer fibrous tissue renovation bracket containing collagen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take by weighing 0.3g collagen protein and dissolve in 5ml hexafluoroisopropanol with an electronic analytical balance, stir until completely dissolving by microthermal magnetic force, obtain the collagen protein spinning solution that concentration is 6% (g / ml); weigh with electronic analytical balance Get 0.3g of thermoplastic polyurethane and dissolve in 5ml of hexafluoroisopropanol, slightly heat and magnetically stir until completely dissolved to obtain a thermoplastic polyurethane spinning solution with a concentration of 6% (g / ml); The ratio of 2:8 is mixed evenly, and the total concentration of the mixed solution is 6%. The electrospinning spinning process is as follows: the spinning voltage is 12kv, the advancing speed of the syringe pump is 1.5ml / h, the receiving distance is 12cm, the needle of No. 9 is selected, and the aluminum foil accepts Or degreasing gauze accepts the fiber to obtain a disordered nanofiber film with an average fiber diameter of about 345 ...

Embodiment 2

[0023] Take by weighing 0.3g collagen protein and dissolve in 5ml hexafluoroisopropanol with an electronic analytical balance, stir until completely dissolving by microthermal magnetic force, obtain the collagen protein spinning solution that concentration is 6% (g / ml); weigh with electronic analytical balance Get 0.3g of thermoplastic polyurethane and dissolve in 5ml of hexafluoroisopropanol, slightly heat and magnetically stir until completely dissolved to obtain a thermoplastic polyurethane spinning solution with a concentration of 6% (g / ml); The ratio of 6:4 is mixed evenly, and the total concentration of the mixed solution is 6%. The electrospinning spinning process is as follows: the spinning voltage is 16kv, the advancing speed of the syringe pump is 1.2ml / h, the receiving distance is 12cm, the No. 9 needle is selected, and the aluminum foil accepts Or degreased gauze accepts the fibers to obtain a disordered nanofiber film with an average fiber diameter of about 208 nan...

Embodiment 3

[0025] Take by weighing 0.4g collagen protein and be dissolved in 5ml hexafluoroisopropanol with electronic analytical balance, microheating magnetic force stirs until dissolving completely, obtain the collagen protein spinning solution that concentration is 8% (g / ml); Weigh with electronic analytical balance Get 0.5g thermoplastic polyurethane and be dissolved in 10ml hexafluoroisopropanol, slightly heat magnetically stir until completely dissolving, obtain the thermoplastic polyurethane spinning solution that concentration is 5% (g / ml); The ratio is 5:8 and mixed evenly, the total concentration of the mixed solution is 6.2%; the electrospinning spinning process is as follows: the spinning voltage is 16kv, the advancing speed of the syringe pump is 1.2ml / h, the receiving distance is 12cm, and the No. 9 needle is selected. Aluminum foil accepts or degreased gauze accepts fibers to obtain a disordered nanofiber film with a thickness of 0.08 nm.

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Abstract

The invention relates to a preparation method of a composite nanofiber tissue repair scaffold which contains collagen. The steps are as follows: firstly, collogen spinning solution is prepared; secondly, thermosplastic polyurethane spinning solution is prepared; thirdly, the collogen spinning solution and the thermosplastic polyurethane spinning solution are mixed according to the proportion and agitated to be even, and then static spinning solution is obtained; fourthly, the static spinning solution is arranged in a static spinning device, the spinning industry parameter is adjusted, the mold shape of a receiving device is changed, and then static spinning composite nanofiber tissue repair scaffolds with different shapes are obtained. The scaffold with the material has good biological compatibility and mechanical property, and higher void factor, and the scaffold is hopeful to be used as the repair scaffold materials of the tissues such as blood vessel, nerve, valve, etc.

Description

technical field [0001] The invention belongs to the field of tissue repair scaffolds, in particular to a preparation method of a collagen-containing composite nanofiber tissue repair scaffold. Background technique [0002] Tissue engineering is a new discipline developed in recent years. It is the product of the joint development and integration of materials science, engineering and life sciences. On the scaffold, through the mutual adhesion, growth and proliferation, and secretion of extracellular matrix between cells, a tissue or organ with a certain structure and function is formed. Therefore, screening suitable scaffold materials is a key factor for the success of constructing tissue engineering scaffolds. In 1934, American Formhals introduced the method of using electrostatic repulsion to obtain polymer fiber filaments for the first time in a patent. [0003] Combining the respective advantages of natural materials and polymer materials, it is expected to screen out a...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/24A61L27/18
Inventor 莫秀梅陈锐
Owner DONGHUA UNIV
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