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A graft fixation device and method

A bone implant and pre-implantation technology, applied in spinal implants, pharmaceutical formulations, drug delivery, etc., can solve problems such as the complexity of popliteal tendon fixation technology

Inactive Publication Date: 2008-04-30
UNIV OF COLORADO THE REGENTS OF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Conventional extra-articular popliteal tendon fixation techniques have complications such as suture stretching, graft channel movement, and the so-called windshield wiper effect, in which the size of the end of the intra-articular drill hole changes due to the movement of the graft within the drill hole. while increasing

Method used

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  • A graft fixation device and method
  • A graft fixation device and method
  • A graft fixation device and method

Examples

Experimental program
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example 1

[0158] Example 1. SMP production

[0159] tert-butyl acrylate (tBA) monomer (Aldrich), poly(ethylene glycol) dimethacrylate (PEGDMA) crosslinker (Aldrich), and photoinitiator 2,2-dimethoxy-2-benzene Acetophenone (Aldrich) was used as obtained without further purification. A polymer solution was prepared by combining 10 wt% PEGDMA, .1 wt% initiator, and the balance tBA. Other crosslinker / monomer ratios are contemplated, and the crosslinker can be used in the range of 1 wt% to 99 wt%. Other photoinitiators include acetophenone, anisoin, anthraquinone, benzene chromium tricarbonyl, benzil, benzoin, benzoin ethyl ether, benzoin isobutyl ether, benzoin iso Methyl ether, benzophenone, 4-benzoyldiphenyl, 2-benzyl-2-(dimethylamino)-4′-morpholinobutyrophenone, 4,4′-bis(diethyl Amino)-4'-benzophenone, 4,4'-bis(dimethylamino)-4'benzophenone, camphorquinone, 2-chlorothioxanth-9-one, dibenzocycloheptatriene Ketone, 2,2-diethoxyacetophenone, 4,4'dihydroxybenzophenone, 4-(dimethylamino...

example 2

[0163] Example 2. SMP thermomechanical characteristics

[0164] The polymer samples were examined using a Perkin Elmer Dynamic Mechanical Analyzer (DMA-7). A three-point bending configuration was used for glass transition (Tg), strain recovery, and stress recovery tests (FIG. 24 inset). Three-point flexural loading allows reasonable stress / strain levels for samples across the temperature range from the glass to the rubber state. Specifically, this configuration allowed for a maximum bending strain of 30% over a span of 5 mm during stress and strain recovery testing. Figure 24 shows a comparison between PEGDMA copolymer and PLA, a biodegradable polymer used in tibial devices. The decrease in storage modulus with increasing temperature indicates that the material can transition from a glassy or rigid state to a rubbery state. Alternatively, Tg can be determined relative to the peak of the tan delta curve.

[0165] The glass storage modulus is an indicator of the hardness o...

example 3

[0167] Example 3. Plunger Production

[0168]Test plunger materials were machined with ratios of 45 wt% PEGDMA to 55% PMMA (polymethyl methacrylate) with 0.1% photoinitiator and mixed in 14 mm diameter glass test tubes. The open end of the test tube was closed with a rubber stopper, and the test tube and solution were placed in a water bath at 0° C. under a UV lamp for 10 minutes. The glass test tube was then removed, leaving a 14 mm cylinder of PEGPMMA with a glass transition temperature (Tg) of 40°C. The plungers were machined with a cylindrical batch machine using coconut oil as lubricant and a shaft speed of 450 RPM to a diameter of approximately 11.5 mm and a length of 25.4 mm. The edges of the device were trimmed to a radius of 0.5 mm to ensure that the device did not shear the soft tissue (tendon) it contacted.

[0169] In addition, various unconstrained (undeformed) shapes were formed in order to demonstrate the variety of possible unconstrained shapes, see FIG. 7 ...

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PUM

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Abstract

A surgical method for anterior cruciate ligament reconstruction includes creating a bone tunnel in a head of a femur of a patient. A connective tissue is inserted into the bone tunnel. A shape memory polymer plug is inserted into the bone tunnel. The plug has a first configuration for insertion and a second configuration for affixation that has a radially expanded dimension that presses the connective tissue against a side wall of the bone tunnel to affix the connective tissue in the bone tunnel. The plug changes from the first configuration to the second configuration in response to an activation temperature equal to or greater than a temperature of the femur.

Description

[0001] Statement Regarding Federally Funded Research and / or Development [0002] This invention was made with support from the National Science Foundation Grant No. NSF-DMI-0200495 and the National Institutes of Health Grant No. NIH-HL-067393, and thus the Government has certain rights in the invention. [0003] related application [0004] This application claims priority to US Provisional Application No. 60 / 667,876, filed April 1, 2005, which is incorporated herein by reference. Background of the invention [0005] Ligaments are strong fibrous soft tissues that connect the joint ends of bones so as to hold them together and facilitate and / or limit movement. Ligamentous injuries are common and are generally more prone to such ligamentous injuries in physically active patients. The anterior cruciate ligament (ACL) of the knee is the ligament that is often injured in this patient. ACL damage can cause knee instability and, if left untreated, can lead to degenerative arthr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44
CPCA61F2002/0858A61L2400/16A61L2430/02A61F2210/0014A61B17/0401A61F2002/0882A61F2002/0864A61F2/0811A61B2017/0448A61L27/50A61F2002/0835A61F2002/0888A61B2017/00871A61L27/16
Inventor K·高尔J·A·泰伯C·M·亚卡科基R·巴茨
Owner UNIV OF COLORADO THE REGENTS OF
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