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Medicine use of potentilla plants total-triterpene extract

A technology of Potentilla genus and total triterpenes, applied in the field of medicine, can solve problems such as limited therapeutic effect, expensive insulin therapy, and reduced insulin therapeutic effect

Inactive Publication Date: 2008-05-07
NAT INST OF PHARMA R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin therapy is expensive and requires daily injections, which puts a lot of pressure on patients
And frequent use of insulin will cause patients to develop insulin resistance, and the effect of insulin treatment will be reduced
Oral administration of other chemical drugs may have limited curative effect, or obvious side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] [Example 1] Effect test of medicine of the present invention on fasting blood glucose in male KKAy diabetic mice

[0022] Test samples: (1) Potentilla water extract; ②Potentilla triterpenoid extract, with a total triterpene content of 55.3%; The total triterpene extract of Fenbaicao, with a total triterpene content of 53.7%; ⑤ the total triterpene extract of Jinlaomei, with a total triterpene content of 66.1%; (6) rosiglitazone; (7) rosiglitazone (positive control drug, ROS).

[0023] Male KKAy diabetic mice (spontaneous diabetic mice, a good animal model of type II diabetes) were adapted to measure random and fasting blood glucose after 2 weeks. According to the measurement results, the mice were divided into 8 groups, 10 in each group, and the normal feeding group ( Blank control group), 4 groups (②, ③, ④, ⑤) of total triterpene extracts of Potentilla plants, and 3 groups of drug control groups ((1), (6), (7)). Dosing according to Table 1, once a day, for 24 consecu...

Embodiment 2

[0030] [Embodiment two] the influence test of medicine of the present invention to the glucose tolerance of male KKAy diabetic mice

[0031] Test samples: ①The total triterpene extract of Potentilla yunnanensis, with a total triterpene content of 51.7%; The total triterpene content is 50.3%: ④The total triterpene extract of Potentia berry leaves, the total triterpene content is 40.1%; The total triterpene extract of Lingcai, the total triterpene content is 35.0%; (7) Rosiglitazone (positive control drug, ROS).

[0032] Male KKAy diabetic mice were adapted to measure random and fasting blood glucose after 2 weeks of adaptation. According to the measurement results, the mice were divided into 8 groups with 10 mice in each group. Group 6 groups (①, ②, ③, ④, ⑤, ⑥), drug control group 1 group ((7)). Administration according to Table 2, once a day, continuous administration for 24 days. After the administration, a glucose tolerance test was carried out, and 2.5 g / kg of glucose wa...

Embodiment 3

[0039] [Embodiment three] Effect test of medicine of the present invention on insulin tolerance in male KKAy diabetic mice

[0040] Test samples: ①The total triterpene extract of Prunus chinensis; the total triterpene content is 35.5%; The total triterpene content is 52.3%; ④The total triterpene extract of P. chinensis, the total triterpene content is 53.7%; Extract, total triterpene content 56.2%; (7) Rosiglitazone (positive control drug, ROS).

[0041] Male KKAy diabetic mice were adapted to measure random and fasting blood glucose after 2 weeks of adaptation. According to the measurement results, the mice were divided into 8 groups with 10 mice in each group. Group 6 groups (①, ②, ③, ④, ⑤, ⑥), drug control group 1 group ((7)). Administration according to Table 2, once a day, continuous administration for 24 days. At the end of administration, the blood glucose values ​​before and after subcutaneous injection of insulin were measured respectively.

[0042] Table 3 Effect...

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Abstract

The invention relates to the application of rosaceae Potentilla plant total triterpene extract during the process of preparing the medicine for remedying and preventing II type diabetes mellitus, Potentilla plant total triterpene extract has an obvious remedy and prevention activity, is the natural medicine for remedying and preventing the II type diabetes mellitus, and has no poisonous and side action for remedying and preventing the II type diabetes mellitus.

Description

technical field [0001] The invention relates to the field of medicine, and relates to the medical application of natural plant extracts for effectively preventing and treating diabetes. The invention is particularly suitable for the treatment and prevention of type II diabetes. It can also be used to treat and prevent hyperglycemia and hyperinsulinemia. Background technique [0002] Diabetes is a common clinical disease caused by the relative or absolute lack of insulin in the human body. The concentration of glucose in the blood increases, and the sugar is excreted from the urine, and symptoms such as polydipsia, polyphagia, and polyuria appear, accompanied by weight loss and dizziness. , fatigue, etc., and further development will cause various serious complications throughout the body, seriously threatening human life. Diabetes is divided into two types. Type I diabetes is insulin-dependent. Patients completely lose their insulin secretion function and rely on insulin i...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/704A61K36/73A61K9/00A61P3/06A61P3/10
Inventor 赵晓霞罗河生
Owner NAT INST OF PHARMA R & D CO LTD
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