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Method for producing temperature sensing polymer gel microsphere

A temperature-sensitive polymer and gel microsphere technology, which is applied in the field of preparation of temperature-sensitive polymer gel microspheres, achieves the effects of uniform gel distribution, wide application prospects, and high input-output ratio

Inactive Publication Date: 2008-05-07
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel is a porous film, not a microsphere

Method used

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  • Method for producing temperature sensing polymer gel microsphere
  • Method for producing temperature sensing polymer gel microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Put 83ml (92.3g, 0.996mol) of methacryloyl chloride and 100ml ethyl acetate in a 250ml constant pressure funnel, and mix well. Measure 105ml (72.9g, 1.24mol) of isopropylamine, 167ml (121g, 1.19mol) of triethylamine and 300ml of ethyl acetate into a 1000ml three-necked bottle, stir evenly, and dissolve the methyl alcohol through a funnel under an ice-water bath. The mixed solution of acryloyl chloride and ethyl acetate was slowly dropped into the three-necked bottle (keep the temperature in the bottle below 5°C), and after the dropwise addition was completed, the stirring reaction was continued for 6 hours (the temperature rose to 5-10°C). After the filtrate was obtained by filtration, it was concentrated to dryness under reduced pressure to obtain a reddish-brown viscous liquid, namely crude N-isopropylmethacrylamide. Then add the obtained N-isopropylmethacrylamide crude product into a large amount of ethyl acetate to dissolve, filter to obtain the filtrate, and then c...

Embodiment 2

[0025] Same as Example 1, but methacryloyl chloride becomes acryloyl chloride, and the number of moles remains unchanged.

Embodiment 3

[0027] The same as Example 1, but when refining N-isopropylmethacrylamide, the filtrate was concentrated to 10% by rotary evaporation using a rotary evaporator.

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Abstract

The invention belongs to the technical field of a functional high molecular material, in particular to a thermometer polymer gel microballoon and there preparation method thereof. The invention directly starts from the raw material of methacrylic chloride and isopropyl amino, and uses the techniques of organic synthesis, free radical polymerization, chemical crosslink, etc. to prepare the thermometer polymer gel microballoon. The microballoon has the even shaping and the good ball forming state, thereby overcoming the difficulties that the traditional thermometer polymer gel microballoon has bigger size, more copolymerization components, higher preparation cost, slow response speed, etc. The preparation method of the invention has simple and convenient technique, rich raw material source, low cost, and high input-output ratio. The polymer gel microballoon size is about 10 to 150 nm, and the gel of polymer microballoon is in even distribution, and the polymer gel microballoon has good thermometer property and response speed, thereby being used in the fields of drug release, thermometer control, etc.

Description

technical field [0001] The invention belongs to the technical field of functional polymer materials, and in particular relates to a preparation method of temperature-sensitive polymer gel microspheres. Background technique [0002] A thermosensitive hydrogel is a hydrophilic polymer gel that can swell significantly in water but is insoluble in water. This type of gel will change from a swollen, soft transparent state to a deswelled, opaque state when the temperature rises above a certain value. If the swelling temperature is lowered below this temperature, the gel state can occur. Reversible change, this temperature is called the lowest critical solution temperature (LCST) of the hydrogel, that is, the phase transition temperature, and hydrogels with this property are called temperature-sensitive hydrogels. Since thermosensitive hydrogels can rapidly absorb and release water with the change of temperature to exhibit their switching properties, they have broad application pr...

Claims

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Application Information

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IPC IPC(8): C08F120/56C08F2/38C08F2/06C08F4/04C08F4/32
Inventor 杨正龙周侃浦鸿汀
Owner TONGJI UNIV
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