Carmustine sustained-release implantation agent for curing entity tumour
A slow-release implant, carmustine technology, applied in the field of medicine, can solve the problems of easy burst release, short drug release cycle, poor tumor cell effect, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0080] Put the weighed slow-release auxiliary material (molecular weight is 15000-25000 PLGA, 50:50) and slow-release modifier (mannitol) into different containers respectively, then add a certain amount of organic solvent to dissolve and mix well (to fully dissolve prevail) and then add different weights of carmustine, re-shake and then vacuum-dry to remove the organic solvent. The dried solid sustained-release implant was immediately shaped to obtain the following sustained-release implant:
[0081] (A) 1% carmustine, containing 1mg carmustine, 99mg PLGA
[0082] (a) 1% carmustine, containing 1 mg carmustine, 95 mg PLGA, 4 mg mannitol;
[0083] (B) 5% carmustine, containing 5 mg carmustine, 95 mg PLGA;
[0084] (b) 5% carmustine, containing 5 mg carmustine, 91 mg PLGA, 4 mg mannitol;
[0085] (C) 10% carmustine, containing 10mg carmustine, 90mg PLGA;
[0086] (c) 10% carmustine, containing 10mg carmustine, 80mg PLGA, 10mg mannitol;
[0087] (D) 15% carmustine, containin...
Embodiment 2
[0092] 10 sustained-release implants in Example 1 were put into the dissolution apparatus respectively to measure the drug cumulative release amount (%) at different times, and it was found that in the sustained-release implants (A), (B), (C ), (D) and (E) five carmustine sustained-release implants that do not contain a sustained-release regulator (mannitol) have obvious burst release phenomenon, and the burst release phenomenon mostly occurs on the 26th-30th day. It accounts for about 40-60% of the total drug content, while (a), (b), (c), (d) and (e) and other carmustine slow-release implants containing slow-release regulators (mannitol) The burst release phenomenon of the medicine is obviously not obvious, and the medicine is released slowly for 3-5 weeks.
Embodiment 3
[0094] Put the weighed sustained-release auxiliary material (PLGA with a molecular weight of 20000-30000, 75:25) and the sustained-release regulator (mannitol) into different containers respectively, then add a certain amount of organic solvent to dissolve and mix (to fully Dissolution prevails) and then add different weights of carmustine, re-shake, and vacuum-dry to remove the organic solvent. The dried solid sustained-release implant was immediately shaped to obtain the following sustained-release implant:
[0095] (A) 1% carmustine, containing 1mg carmustine, 99mg PLGA
[0096] (a) 1% carmustine, containing 1 mg carmustine, 95 mg PLGA and 4 mg sorbitol;
[0097] (B) 5% carmustine, containing 5 mg carmustine, 95 mg PLGA;
[0098] (b) 5% carmustine, containing 5 mg carmustine, 91 mg PLGA and 4 mg sorbitol;
[0099] (C) 10% carmustine, containing 10mg carmustine, 90mg PLGA;
[0100] (c) 10% carmustine, containing 10 mg carmustine, 80 mg PLGA and 10% sorbitol;
[0101] (D) ...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com