Technical new method for extracting artemisinin from sweet wormwood plants by ultrasonic assistance

Abstract

The invention relates to a novel process method for utilizing the ultrasonic wave to extract the artemisinin from the artemisia annua Linn. By adopting the orthogonal experimental design, the method obtains the target compounds through a plurality of technical parameters in the process of screening and extraction. The stems and leaves of the artemisia annua Linn serving as the materials and 80 per cent ethanol are added in an ultrasonic extraction batch at a ratio of solid to liquid (Kg:L) ranging from 1 to 15 to 1 to 17; a separate-excited ultrasound generating device and a radial vibration columnar transducer are adopted; the ultrasonic power is 1000W, the ultrasonic frequency is 35kHz, the extraction is carried out for one time at two minutes interval with an action time of 3 minutes and the total extraction time is 30min; the temperature is 40 DEG C; the mixtures in the ultrasonic extraction batch are subject to the air-lift type stirring and the extract is put into the ultrafiltration, and the filtrates in equivalent volume are subject to the petroleum ether ultrasonic extraction at a temperature ranging from 30 DEG C to 60 DEG C on the conditions that the separate-excited ultrasound generating device and the radial vibration columnar transducer are adopted with an ultrasonic power of 1000W and a ultrasonic frequency of 30kHz and the ultrasound has a continous effect for 10 minuts with a total extraction time of 15 minutes at a temperature of 25 DEG C; the air-lift type stirring is carried out, the ether extraction liquid is decolored by the activated carbon and concentrated by reducing the pressure and then the obtained solution is cooled down to be crystalized; 50 per cent ethanol is recrystalized. The extraction rate of the artemisinin from artemisia annua Linn is 97.25 per cent.

Description

1. Technical field [0001] The invention relates to a new technology for extracting effective components of traditional Chinese medicines, in particular to a new process for efficiently extracting artemisinin from Artemisia annua plants by using ultrasonic waves. 2. Background technology [0002] The chemical meaning of extraction is to use a suitable solvent and an appropriate method to leach the required target components from the sample material as completely as possible, avoiding or reducing the introduction of harmful components or other impurities. Extracting chemical components from plants for medicinal purposes has a history of nearly 5,000 years in the traditional medicine of the motherland. Traditional extraction methods can be divided into two categories according to the different energy requirements of the extraction process. One is the heating extraction method, which mainly includes different methods such as decoction extraction, reflux extraction and Soxhlet e...

AI Technical Summary

Problems solved by technology

Specifically, the shortcoming of chemical solvent extraction method is energy, raw material consumption are big, and extraction efficiency is low, and industrial pollution discharge amount is big etc. (for example, described in CN1092073A method)

Although the supercritical fluid extraction method has been improved in extraction efficiency, the equipment required by this type of method is complicated and requires CO 2 Gas pumps, compression pumps, heat exchangers and other equipment must be carried out under a certain pressure (extraction pressure is 8-32 MPa, analytical pressure is 4-8 MPa), which makes the industrial application cost of this

Images