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Antiviral antibacterial medicinal composition and preparation thereof

An antibacterial drug and composition technology, applied in the field of antiviral and bacterial drug compositions and their preparation, can solve the problems of adverse reactions, poor quality and low purity of preparations, and achieve precise pharmacological action, fast absorption, and low dosage Effect

Inactive Publication Date: 2011-03-16
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the poor quality and low purity of existing baicalin and baicalein raw materials, their preparations are prone to adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 100 grams of Scutellaria baicalensis extract or baicalin crude product, add 1500 milliliters of distilled water, add 1 gram of glucosidase and stir to dissolve at 50 ° C, adjust the pH of the solution to 5, filter to remove residue, and add the filtrate to the chromatograph containing artificial zeolite with a particle size of 40 mesh. In the column, elute with a 1:1 mixed solution of water and ethanol at pH 6, and collect baicalin and baicalein components respectively (using baicalin and baicalein reference substances as artificial zeolite chromatography indicators); the collected baicalin and baicalein eluent to adjust the pH of the solution to 1.5, heat to 70°C, place for 24h, naturally precipitate, filter, collect the precipitate, and dry to obtain high-purity baicalin and high-purity baicalein respectively.

[0023] Weigh 100 grams of high-purity baicalin and 1 gram of high-purity baicalein, add 3.5 grams of vitamin C for injection, add 1000 milliliters of wate...

Embodiment 2

[0025] Take 200 grams of Scutellaria baicalensis extract or baicalin crude product, add 4000 milliliters of distilled water, add 2 grams of baicalinase at 40 ° C and stir to dissolve, adjust the pH of the solution to 6, filter to remove slag, add the filtrate to the chromatograph containing silica gel with a particle size of 60 mesh In the column, elute with a 1:3 mixed solution of water and ethanol at pH 7, collect baicalin and baicalein components respectively, and use baicalin and baicalein reference substances as silica gel chromatography indicators; the collected baicalin and baicalein Adjust the pH of the solution to 2 with the element eluent, heat to 80°C, place for 36 hours, naturally precipitate, filter, collect the precipitate, and dry to obtain high-purity baicalin and high-purity baicalein respectively.

[0026] Take by weighing 150 grams of high-purity baicalin and 1.5 grams of high-purity baicalein, add 6.5 grams of vitamin C for injection, add 1000 milliliters of...

Embodiment 3

[0028] Take 150 grams of Scutellaria baicalensis extract or baicalin crude product, add 3000 milliliters of distilled water, add 2 grams of glucuronidase at 30°C and stir to dissolve, adjust the pH of the solution to 7, filter to remove residue, add the filtrate to the macroporous adsorbent with a particle size of 60 mesh In the resin chromatography column, elute with a 1:4 mixed solution of water and ethanol at pH 8, collect baicalin and baicalein components respectively, and use baicalin and baicalein reference substances as macroporous adsorption resin chromatography indicators; Adjust the pH of the collected baicalin and baicalein eluents to 3, heat to 90°C, place for 50 hours, naturally precipitate, filter, collect the precipitate, and dry to obtain high-purity baicalin and high-purity baicalin respectively. Baicalein.

[0029] Take by weighing 80 grams of high-purity baicalin and 50 grams of high-purity baicalein, add 2 grams of vitamin C for injection, add 1000 millilit...

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Abstract

The present invention discloses an antiviral antibacterial medicine combination which contains the high-purity baicalin with the weight percentage of 2 percent to 10 percent of the high-purity baicalin , 0.1 percent to 5 percent of scutellarin and the pharmic acceptable auxiliary material with the rest quantity. The high-purity baicalin and the high-purity scutellarin are obtained by processing crude baicalin or scutellarin extract mainly by enzymolysis, absorption chromatography and crystallization technology. The baicalin and the scutellarin in the medicine combination of the present invention have high purity and low dosage and take effect fast; the medicine combination of the present invention has long effective plasma concentration lasting time, does not have non-drug-induced bad reaction and does not have drug resistance; LD50 dosage is improved by 1.5 times. The preparation has obvious curative effect at the aspects of antivirus, bacteriostasis and diminishing inflammation and also has good effect at the aspects of removing oxygen free radical and resisting biological oxygenation.

Description

technical field [0001] The invention relates to an antiviral and bacterial pharmaceutical composition and a preparation method thereof, in particular to an antiviral, antibacterial and anti-inflammatory pharmaceutical composition containing high-purity baicalin and baicalein and a preparation method thereof. Background technique [0002] Baicalin is one of the medicinal components of Scutellaria baicalensis, a traditional Chinese medicine. It mainly exists in the roots, stems and leaves of Scutellaria baicalensis. , anti-tumor, hypoglycemic, hypotensive, etc., clinically mainly used for the treatment of hepatitis B, viral influenza, infection, hypertension, diabetes, AIDS and other diseases. Due to the prominent pharmacological effects of baicalin, this ingredient is contained in many traditional Chinese medicine compound preparations, such as oral preparations: Qingkailing Granules, Shuanghuanglian Oral Liquid, Yinhuang Buccal Tablets, etc. [0003] Baicalein is the hydrol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/353A61P31/10A61P31/12A61P1/16
Inventor 任慧霞王厚全
Owner SHANDONG UNIV