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Moisture absorption humectant and method for preparing same

A moisturizing agent and wet preparation technology, applied in the field of daily chemicals, can solve the problems of hyaluronic acid unable to meet market needs, complicated separation process, difficult to collect and handle, etc. Effect

Inactive Publication Date: 2012-12-05
烟台大境生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the distribution of hyaluronic acid in animal tissues is very special, mainly in: connective tissue, umbilical cord, human serum, cockscomb, joint synovial fluid, cartilage, eye vitreous, etc. The raw materials are limited, difficult to collect and process, high in price and low in content , complex separation process, etc.; and the use of fermentation to produce hyaluronic acid, many scholars in my country have actively carried out research in this area in recent years, but it is only at the research and initial stage
Due to the above reasons, hyaluronic acid cannot meet the needs of the market

Method used

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  • Moisture absorption humectant and method for preparing same
  • Moisture absorption humectant and method for preparing same
  • Moisture absorption humectant and method for preparing same

Examples

Experimental program
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Effect test

Embodiment 1

[0016] The preparation of carboxymethyl hyaluronic acid: 2g hyaluronic acid (see figure 1 ) was added to 10mL isopropanol and stirred at room temperature to swell for 10min, and 10mol / L NaOH solution was added in 6 times, 0.5mL each time, once every 4min, and stirred for 40min after the last addition to obtain basic hyaluronic acid. Chloroacetic acid was added in 4 times, once every 6 minutes. After the addition was completed, the reaction was stirred at 35°C for 5h, filtered with suction, then washed with 30mL of methanol, filtered with suction, and dried at 50°C to obtain carboxymethyl hyaluronic acid (see figure 2 , image 3 , Figure 4 ).

[0017] The prepared carboxymethyl hyaluronic acid is used as a hygroscopic moisturizing agent.

Embodiment 2

[0019] The difference from Example 1 is:

[0020] Preparation of carboxymethyl hyaluronic acid: Add 2g of hyaluronic acid to 40mL of isopropanol, stir and swell at room temperature for 40min, add 10mol / L NaOH solution in 6 times, 0.5mL each time, once every 4min, and stir for 40min after the last addition , to obtain basic hyaluronic acid, then add 3 g of solid chloroacetic acid in 6 times, once every 4 minutes, stir and react at 75 ° C for 1 h after the addition, filter with suction, then wash with 30 mL of methanol, filter with suction, and dry at 70 ° C Dry to obtain carboxymethyl hyaluronic acid.

Embodiment 3

[0022] The difference from Example 1 is that the hyaluronic acid swollen by an alkaline isopropanol solution with a molar mass ratio of 1:5 reacts with chloroacetic acid at 50°C in an excess of alkaline isopropanol solution 3h, and then washed with methanol, suction filtered, and dried at 60°C to obtain carboxymethyl hyaluronic acid. Among them, chloroacetic acid was added into hyaluronic acid in 6 times with an interval of 5 minutes. The hyaluronic acid swollen by the alkaline isopropanol solution is to stir and swell the hyaluronic acid through the alkaline isopropanol solution at room temperature for 30 minutes, wherein the amount of the alkaline isopropanol solution is 10 times the mass volume of the hyaluronic acid , the alkaline isopropanol solution is isopropanol with a volume ratio of 20:3 and a concentration of 10mol / L sodium hydroxide, wherein the sodium hydroxide is added to the isopropanol in 6 times with an interval of 6 minutes.

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Abstract

The invention relates to a moisture absorbing humectant of polysaccharides and a preparation method, belonging to the fields of daily chemicals and medical industry; wherein, carboxymethyl hyaluronic acid is adopted for the moisture absorbing humectant; the preparation method comprises steps as follows: 1 to 5-hour reaction is carried out for the hyaluronic acid swollen in alkaline isopropyl alcohol solution and the chloroacetic acid with a molar mass ratio between 1 to 6 and 1 to 4 in the excessive alkaline isopropyl alcohol solution under temperatures between 35 and 75 DEG centigrade, and then pumping filtration and drying are carried out to acquire the moisture absorbing humectant. With the carboxymethyl hyaluronic acid acquired through effective synthesis, the production cost hardly increases, while the moisture absorption and maintaining performance is remarkably improved, so as to enhance the activity and indirectly reduce the production cost. By adopting the carboxymethyl hyaluronic acid with better moisture absorption and maintaining performance than that of the hyaluronic acid as the moisture absorbing humectant, the preparation method for moisture absorbing humectant of polysaccharides has the advantages of low cost and high yielding.

Description

technical field [0001] The invention relates to the field of daily chemicals and the pharmaceutical industry, in particular to a polysaccharide moisture-absorbing and moisturizing agent and a preparation method thereof. Background technique [0002] Hyaluronic acid (Hyaluronic acid, HA for short), also known as hyaluronic acid, is an acidic polymucopolysaccharide, which is a white amorphous solid, odorless and tasteless, soluble in water and insoluble in organic solvents. HA has strong hygroscopicity and is currently the best moisturizing substance found in nature. Its water retention value is as high as 500mL / g, which is better than glycerin, propylene glycol, sorbitol, polyethylene glycol, lactic acid, sodium pyrrolidone carboxylate, etc. Moisturizing agent is recognized as the most ideal natural moisturizing factor by the international cosmetics industry. Nowadays, there are more and more high-end cosmetics added with hyaluronic acid in the domestic and foreign cosmetics...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08
Inventor 郭占勇苗凤萍薛钦昭杨少丽衣悦涛王艳董方刘景利
Owner 烟台大境生物科技有限公司
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