Water-soluble metal alcoholate derivative, process for production of the derivative, and solid gelatinous agent for external application comprising the derivative

A metal alcoholate, water-soluble technology, applied in chemical instruments and methods, silicon organic compounds, titanium organic compounds, etc., can solve the problem of no water-based gelling agent, etc., achieve high practicability, excellent scalability, excellent Using tactile effects

Inactive Publication Date: 2008-08-13
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no attempt to use this polyol-substituted silane derivative as a water-based gelling agent for external preparations.

Method used

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  • Water-soluble metal alcoholate derivative, process for production of the derivative, and solid gelatinous agent for external application comprising the derivative
  • Water-soluble metal alcoholate derivative, process for production of the derivative, and solid gelatinous agent for external application comprising the derivative
  • Water-soluble metal alcoholate derivative, process for production of the derivative, and solid gelatinous agent for external application comprising the derivative

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preparation example Construction

[0064] As the water-soluble metal alkoxide derivative obtained by the production method of the present invention, more specifically, Si-(O-CH 2 -CH 2 -OH) 4 , Si-(O-CH 2 -CH 2 -CH 2 -OH) 4 , Si-(O-CH 2 -CH 2 -CHOH-CH 3 ) 4 , Si-(O-CH 2 -CHOH-CH 2 -OH) 4 Wait.

[0065] The water-soluble metal alkoxide derivative obtained by the preparation method of the present invention generates medium-sized metal oxide gel (for example, gel-like silica) and polyhydric alcohol through hydrolysis and dehydration condensation reactions in water. Due to this property, it can be used, for example, as a precursor of porous silica for chromatography, as a silica coating agent on the surface of inorganic or organic compounds, or as a silica matrix forming agent for immobilizing catalysts, enzymes, etc. in the structure. In addition, since the water-soluble metal alkoxide derivatives obtained by the preparation method of the present invention are dissolved in water, no acid, alkali or or...

Embodiment 1

[0074] Hereinafter, the present invention will be described in more detail by giving specific examples, but the present invention is not limited by these examples.

[0075] The present inventors first attempted to prepare ethylene glycol-substituted silane derivatives under various conditions using initially tetraethoxysilane and ethylene glycol.

[0076] Ethylene glycol substituted silane derivatives

Embodiment 2

[0084] 4.19 g (0.02 mol) of tetraethoxysilane and 4.97 g (0.08 mol) of ethylene glycol were added to 50 ml of acetonitrile, and 0.5 g of strongly acidic ion exchange resin (DowEX 50W-X8: manufactured by Dow Chemical Co., Ltd.) was added as After solid catalyst, mixing and stirring at room temperature for 48 hours. After the solid catalyst was separated by filtration, ethanol and acetonitrile were distilled off under reduced pressure to obtain 4.0 g of a transparent viscous liquid. The product was mixed with the same amount of water at room temperature to form a uniform, transparent gel (yield 73%).

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Abstract

Provides a method for the production of water-soluble silane derivatives that can be easily separated and purified, and can be carried out at a temperature of 90°C or lower, which is practically applicable in industry, and can produce products that are excellent in form stability against temperature changes or added substances and that are excellent in usability Compounds for solid gel-like external preparations. Water-soluble silane derivatives can be prepared by substituting metal alkoxides with polyols in the presence of a solid catalyst. According to this preparation method, the catalyst can be easily separated from the product, and can be carried out at a temperature below 90 ° C. reaction. In addition, by blending the water-soluble metal alkoxide derivative obtained in this way into a water-based external preparation formulation, the base can be sufficiently cured, and the obtained solid gel-like base is stable in form against temperature changes and additives. It is excellent, and since it disintegrates easily during use, it is also excellent in usability such as finger removal property and spreadability at the time of application.

Description

[0001] Associate application [0002] This application claims the priority of Japanese Patent Application No. 2005-234772 filed on August 12, 2005 and Japanese Patent Application No. 2005-234773 filed on August 12, 2005, and uses the contents thereof here. technical field [0003] The present invention relates to a water-soluble metal alcoholate derivative, its preparation method and a solid gel-like external preparation containing the substance, in particular to the improvement of the preparation method and shape stability of a polyhydric alcohol-substituted water-soluble metal alcoholate derivative And preparation of a solid gel-like external preparation with improved usability. Background technique [0004] Alkoxysilanes generate silanol groups through hydrolysis of alkoxy groups, and further form silicon oxide through dehydration condensation. Therefore, alkoxysilanes are used in various applications as silicon oxide precursors in the sol-gel method. Conventionally, te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F7/04A61K9/10A61K47/10C07C31/20C07F7/28C09K3/00
Inventor 石川由布子坂本一民世喜利彦矢岛勋高桥俊渡边启
Owner SHISEIDO CO LTD
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