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Hydrogel dressings and preparation thereof

A technology of hydrogel and water-soluble polymers, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems that dressings stimulate wounds, fail to promote wound healing, and affect production efficiency, so as to shorten the preparation time and achieve good results. Effect of coagulation and long drug effect cycle

Inactive Publication Date: 2008-08-20
SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its formula contains chitosan, but chitosan is insoluble in water, but soluble in dilute acid solution, so the acid needs to be neutralized during the preparation process, otherwise the dressing will irritate the wound; the hydrogel dressing also contains moisturizing Additives such as agent and plasticizer, these additives are easy to separate out in the use process of dressing, have certain side effect to wound; Its used medicine mainly is some anti-inflammatory, antibacterial medicine, does not have the function of promoting wound healing; In its preparation method The cycle freezing and thawing step takes a long time, and the freezing and thawing time takes 8 to 30 hours, which affects its production efficiency

Method used

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  • Hydrogel dressings and preparation thereof
  • Hydrogel dressings and preparation thereof
  • Hydrogel dressings and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Dissolve 5g of polyvinyl alcohol in 50g of distilled water to make solution A, and at the same time dissolve 5g of water-soluble chitin in 40g of distilled water to make solution B, mix A and B, stir evenly, and pour it into a container after ultrasonic defoaming. into an airtight container filled with nitrogen, 60 Coγ-rays were irradiated with 10kGy, turned over to make the irradiation uniform, and then taken out, placed in a cycle freezer under sterile conditions to freeze-thaw 4 times, the freezing temperature was -20°C, and the time was 1 hour. The temperature is room temperature, and the time is 0.5 hours; the prepared hydrogel is vacuum freeze-dried for 24 hours under sterile conditions, and then added to 5 wt% Yunnan Baiyao aqueous solution under sterile conditions, soaked for 24 hours, and taken out Sealed and stored at low temperature. The components of the prepared hydrogel are: 5wt% PVA, 5wt% water-soluble chitin, 5wt% Yunnan Baiyao.

Embodiment 2

[0032]Dissolve 13g of polyvinyl alcohol and 2g of agar in 75g of distilled water to make solution A. At the same time, dissolve 1g of water-soluble chitin in 9g of distilled water to make solution B. Mix A and B, stir well, let stand to defoam and pour Put it into the container, irradiate 70kGy with high-energy electron beam rays, take it out, and put it in a circulating freezer under aseptic conditions to cycle freezing-thawing once, the freezing temperature is -30°C, the time is 7 hours, and the melting temperature is 40°C. The time is 7 hours; dry the prepared hydrogel in a vacuum oven for 4 hours under sterile conditions, then add it to 3wt% Yunnan Baiyao aqueous solution under sterile conditions, soak for 4 hours, take it out and seal it, and store it at low temperature . The prepared hydrogel components are: 13wt% PVA, 2wt% agar, 1wt% water-soluble chitin and 3wt% Yunnan Baiyao.

Embodiment 3

[0034] Dissolve 8.5g of polyvinyl alcohol in 63g of distilled water to make solution A. At the same time, dissolve 0.5g of water-soluble chitin in 28g of distilled water to make solution B. Mix A and B, stir evenly, and pour into In the container, irradiate 50kGy with high-energy electron beam rays at room temperature, take it out, cycle freezing-thawing three times under sterile conditions, the freezing temperature is -18°C, the time is 5 hours, the melting temperature is 30°C, and the time is 1.5 hours; The prepared hydrogel was dried at room temperature for 72 hours under aseptic conditions, then added to 1 wt% dexamethasone aqueous solution under aseptic conditions, soaked for 72 hours, taken out and sealed, and stored at low temperature. The prepared hydrogel has the following components: 8.5wt% PVA, 0.5wt% water-soluble chitin, and 1wt% dexamethasone.

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Abstract

The invention discloses a hydrogel dressing, comprising water-soluble polymer, water-soluble chitin derivatives and solvent. The invention also discloses the method for preparing the hydrogel dressing, which is as follow: firstly, irradiation, secondly, circulation of freezing and unfreezing. The hydrogel dressing has the advantages of high transparency, large swelling capacity, high strength, low water evaporation rate, functions of antibacterial, anti-inflaminatory, hemostasis and promoting wound healing, no additive, and ability of providing a good healing environment for wound. The preparation method has the advantages of simple method, less time consumption, high efficiency, and ability of preparing the hydrogel dressing with high transparency, large swelling capacity and high strength.

Description

technical field [0001] The invention relates to a hydrogel dressing suitable for burns, scalds and traumatic wounds and a preparation method thereof. Background technique [0002] For a long time, people have generally defined medical dressings as a general term for gauze, gauze strips, cotton balls and cotton pads used to clean and protect wounds. The main function of this traditionally defined dressing is to protect the wound during the wound healing process, but it has little effect on wound healing. [0003] In 1962, Dr. George Winter, a British scientist, discovered that a humid environment is conducive to wound healing. Since then, various new dressings based on this idea have been widely developed, such as hydrocolloid dressings and hydrogel dressings. Hydrogel dressings have the advantages of significantly relieving pain, absorbing a large amount of wound effluent, breathable and moisturizing, will not damage the healed wound tissue when changing the dressing, and ...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/28
Inventor 杨小敏朱智勇
Owner SHANGHAI INST OF APPLIED PHYSICS - CHINESE ACAD OF SCI
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