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Arbidol granular formulation and fluidized-bed coating preparation thereof

A technology of arbidol granules and fluidized bed coating, which is applied in the directions of antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of low particle encapsulation rate, complicated production process and long production cycle. and other problems, to achieve the effects of uniform coating particles, simple and easy process, and short production cycle.

Inactive Publication Date: 2008-08-27
徐向兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, ordinary coating machines were commonly used to prepare granules. The production process is complicated, the encapsulation rate of granules is low, the production cycle is long, and the production cost is high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Arbidol granules (specification: 20mg)

[0022] Raw material: Arbidol Hydrochloride (Medicinal) 20g

[0023] Sucrose (medicinal) 304g

[0024] Microcrystalline cellulose (medicinal) 40g

[0025] Stevia 2g

[0026] Arabic gum 10g

[0027] 2% polyacrylic resin IV No. IV ethanol coating solution, made into 1000 bags.

[0028] crafting process:

[0029] 1. According to the production instructions, go to the warehouse to receive the raw and auxiliary materials that have passed the inspection, remove the outer packaging, and send them to the ingredients room;

[0030] 2. Weigh the original dressing accurately according to the prescription, and ask for double check;

[0031] 3. Pass the Abidol hydrochloride granules through a 100-mesh sieve in advance for use;

[0032] 4. Mix the sieved Arbidol with sucrose and microcrystalline cellulose in equal amounts, and then pass through an 80-mesh sieve twice;

[0033] 5. Stir the sieved mixture with an appropriate amount of wate...

Embodiment 2

[0042] Example 2: Arbidol granules (specification: 100mg)

[0043] Raw material: Arbidol Hydrochloride (Medicinal) 100g

[0044] Sucrose (medicinal) 1520g

[0045] Microcrystalline Cellulose (Medicinal) 200g

[0046] Stevia 10g

[0047] Arabic gum 50g

[0048] 6% polyacrylic resin IV No. IV ethanol coating solution, made into 1000 bags.

[0049] crafting process:

[0050] 1. According to the production instructions, go to the warehouse to receive the raw and auxiliary materials that have passed the inspection, remove the outer packaging, and send them to the ingredients room;

[0051] 2. Weigh the original dressing accurately according to the prescription, and ask for double check;

[0052] 3. Pass the arbidol hydrochloride through a 100 mesh sieve in advance for use;

[0053] 4. Mix the sieved Arbidol with sucrose and microcrystalline cellulose in equal amounts, and pass through an 80-mesh sieve twice;

[0054] 5. Stir the sieved mixture with an appropriate amount of water to mak...

Embodiment 3

[0063] Example 3: Arbidol granules (specification: 200mg)

[0064] Raw material: Arbidol Hydrochloride (Medicinal) 200g

[0065] Sucrose (medicinal) 3040g

[0066] Microcrystalline Cellulose (Medicinal) 400g

[0067] Stevia 20g

[0068] Arabic gum 100g

[0069] 8% polyacrylic resin IV No. ethanol coating solution, made into 1000 bags.

[0070] crafting process:

[0071] 1. According to the production instructions, go to the warehouse to receive the raw and auxiliary materials that have passed the inspection, remove the outer packaging, and send them to the ingredients room;

[0072]2. Weigh the original dressing accurately according to the prescription, and ask for double check;

[0073] 3. Pass the arbidol hydrochloride through a 100 mesh sieve in advance for use;

[0074] 4. Mix the sieved Arbidol with sucrose and microcrystalline cellulose in equal amounts, and pass through an 80-mesh sieve twice;

[0075] 5. Stir the sieved mixture with an appropriate amount of water to make a...

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PUM

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Abstract

The invention discloses an arbidole granule preparation and a fluidized-bed coating preparation method thereof. The direct granulation of powder in a fluidized bed improves fluidity and reduces fly ash. The fluidized bed equipment is provided with discharge holes to eliminate explosion hazards. The coating process is performed in a closed system without leakage risk. The equipment has no dead angles, rapid discharge, easy cleaning, and compliance to the GMP standards. Compared with the prior art, the preparation method has simple process, high product quality, short production cycle and low production cost.

Description

Technical field [0001] The invention relates to arbidol granules and a preparation method thereof, in particular to a preparation method of arbidol granules and a fluidized bed coating thereof. Background technique [0002] Arbidol is a highly effective drug for the prevention and treatment of influenza A and B and other acute respiratory virus infections. The mechanism of action is different from the commonly used antiviral chemotherapy drugs in clinical practice such as ribavirin, amantadine and rimantadine. It fights influenza viruses by inducing interferon and enhancing immune function. It can effectively treat influenza and other acute respiratory virus infections. It has a broader antiviral spectrum than amantadine, and it has a antagonistic effect on influenza A and B viruses. , Also has the effect of activating macrophages. In addition, recent studies have shown that the drug also has a better inhibitory effect on the SARS virus at a lower safe concentration. [0003] Abi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/404A61P31/12A61J3/06
Inventor 徐向兵丁峰徐永平张荣久金小飞
Owner 徐向兵
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