Arbidol granular formulation and fluidized-bed coating preparation thereof

Abstract

The invention discloses an arbidole granule preparation and a fluidized-bed coating preparation method thereof. The direct granulation of powder in a fluidized bed improves fluidity and reduces fly ash. The fluidized bed equipment is provided with discharge holes to eliminate explosion hazards. The coating process is performed in a closed system without leakage risk. The equipment has no dead angles, rapid discharge, easy cleaning, and compliance to the GMP standards. Compared with the prior art, the preparation method has simple process, high product quality, short production cycle and low production cost.

Description

Technical field

[0001] The invention relates to arbidol granules and a preparation method thereof, in particular to a preparation method of arbidol granules and a fluidized bed coating thereof. Background technique

[0002] Arbidol is a highly effective drug for the prevention and treatment of influenza A and B and other acute respiratory virus infections. The mechanism of action is different from the commonly used antiviral chemotherapy drugs in clinical practice such as ribavirin, amantadine and rimantadine. It fights influenza viruses by inducing interferon and enhancing immune function. It can effectively treat influenza and other acute respiratory virus infections. It has a broader antiviral spectrum than amantadine, and it has a antagonistic effect on influenza A and B viruses. , Also has the effect of activating macrophages. In addition, recent studies have shown that the drug also has a better inhibitory effect on the SARS virus at a lower safe concentration.

[0003] Abi...