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Instrument for performing automatic measurement for magnetic-sensing biological chips

A technology of biochips and measuring instruments, which is applied in the field of measurement, can solve the problems of few test devices reported in literature and no reports of fully automatic test instruments, and achieve the effects of improving detection sensitivity, improving repeatability, and reducing costs

Active Publication Date: 2008-10-08
DONGGUAN BOSH BIOTECHNOLOGIES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there have been reports on magnetic sensor biochips in the literature, there are few reports on the test equipment used in the magnetic sensor biochips, and there are no relevant reports on the corresponding fully automatic test instruments.

Method used

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  • Instrument for performing automatic measurement for magnetic-sensing biological chips
  • Instrument for performing automatic measurement for magnetic-sensing biological chips
  • Instrument for performing automatic measurement for magnetic-sensing biological chips

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Embodiment 1 Magnetic sensing biochip sample boat:

[0087] Referring to Fig. 1a and Fig. 1b sample boat 1: the substrate 111 is made of glass or ceramics or a single crystal silicon material or polymer material with a layer of silicon dioxide oxidized on the surface, and a penetrating small hole is opened at a suitable position of the substrate 111 The opening 171 of the sample chamber is used as a sample injection hole, and the sample port plug 171' can be sealed to seal the sample port. There is a microchannel layer 121 on the substrate 111, and several microfluidic channels and various liquid storage chambers are formed on the body of the microchannel layer 121. The microfluidic channel 122 contains at least one reaction chamber 131, one sample storage chamber 141, one The pump chamber 151, a waste liquid chamber 161 and more than one fluid injection ports 181 are used for injecting reaction reagents or buffer solutions or cleaning solutions. The pump chamber 151 i...

Embodiment 2

[0088] Embodiment 2: as figure 2 Shown is a magnetic-sensing biochip measuring instrument, comprising:

[0089] The pressing device 2 is made up of a stepping motor control circuit 21 , an electric motor or electric stepping motor 22 and a driving pull rod 23 , and the signal of the stepping motor control circuit 21 is controlled by the microprocessor 6 . With the driving structure of this electric motor or electric stepper motor---drive pull rod 23 to sample boat 1 (see details figure 2 ) to apply pressure to the pump chamber 151 connected to the sample storage chamber 141 so that the fluid enters the reaction chamber 131 on the sample boat 1; The reaction chamber 131.

[0090] In addition to electric motors or electric stepper motors, other linear actuating devices such as piezoelectric devices can also be used as the pressure applying device 2 .

[0091] Fluid injection system 3: consists of a syringe 31, that is, a first syringe 311, a second syringe 312; a stepping mot...

Embodiment 3

[0108] Example 3 Preparation of Magnetic Sensing Biochip Sample Boat

[0109] Fig. 3a and Fig. 3b are sample boats: with glass or pottery or the monocrystalline silicon material or high polymer material of a layer of silicon dioxide oxidized on the surface as the substrate 111, open a penetrating sample chamber opening at the appropriate position of the substrate 111 171, used as a sample injection hole, can seal the sample port stopper 171' for sealing the opening 171 of the sample chamber. Above the substrate 111 is a microchannel layer 121. The microchannel layer 121 adopts a microfluidic channel flexible layer, which is made of a flexible material such as silicon rubber by mold molding, or is made of a plastic material such as plexiglass (PMMA), polycarbonate (PC) , polypropylene (PP), nylon, polytetrafluoroethylene, polyether ether ketone (PEEK), silicone rubber, etc., utilize the mold forming method to make the microfluidic channel 122 and the liquid sample storage chamb...

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Abstract

The invention discloses an apparatus executing automatic measurement to magnetic-sensing sensing biological chips, which includes a pressure exerting apparatus, directly or indirectly exerting physical pressure to sample store room located on a biological chips sample boat; a fluid syringe, located at a or several fluid injection port conjoint with a reaction chamber on the biological chips sample boat, connected with injection tube of the injection tube, for injecting fluid flow in the reaction chamber; a biological chip integrated with a magnetic-sensing sensor, placed in the micro-fluid duct of the sample boat; a magnetic field producing apparatus, adding the magnetic field at a position of the biological sample boat corresponding to the magnetic-sensing sensor; a chip operation and information selecting electron device, for supplying power source, control signal and information connection to the biological chips; a microprocessor, which control and coordinates the components and user interface, for processing the obtained information. The invention resolves problems of low testing sensitivity and complicated equipment, thereby having high testing sensitivity and simple detection device.

Description

technical field [0001] The invention belongs to the technical field of measurement of chemical and biological target molecules, cells, microorganisms, etc., and relates to a magnetic-sensitivity biological chip tester, in particular to a Hall device, giant magnetoresistance and magnetic tunnel array biological chip readout instrument, that is, a measuring instrument. Background technique [0002] Magnetic sensors are an important part of sensor products. Magnetic sensors have been widely used, such as magnetic memory in computer hard disks, angle sensors in automobiles, etc. It was not until 1998 that Baselt et al first reported the use of magnetic particles labeled with biomolecules and giant magnetoresistance (GMR) sensors to detect biological target molecules and published a patent (US5981297), thus creating the application of magnetic sensors in the field of biotechnology research precedent. The principle of magnetic sensitive biosensors for testing biomolecules is to d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G01N27/72
CPCG01N27/72
Inventor 高云华
Owner DONGGUAN BOSH BIOTECHNOLOGIES LTD
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