Composition of doxycycline hydrochloride injection for animals and preparation technique thereof
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A technique for preparing doxycycline hydrochloride and its preparation process, which is applied in the field of composition and preparation process of doxycycline hydrochloride injection for veterinary use, can solve the problems of good stability, unresolved preparations, and small side effects, and achieve stability Enhanced, highly curative, solubility-enhancing effects
Inactive Publication Date: 2008-11-12
CHENGDU QIANKUN VETERINARY PHARMA
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The purpose of this application is that the compound preparation focuses on broad-spectrum antibacterial aspects, and does not a
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Embodiment 1
[0012] (1) Take 10ml of water for injection, add 0.3g of sodium formaldehyde sulfoxylate and stir to dissolve, add 30ml of α-pyrrolidone and 30ml of dimethylacetamide respectively, and stir evenly;
[0013] (2) Weigh 3.5g of MgO, add to 1 solution and stir evenly, then add 23g of doxycycline hydrochloride, stir until clear liquid, adjust pH to 6.2 with concentrated hydrochloric acid.
[0014] (3) Filter with a 0.45mm organic membrane, pack in ampoules, and sterilize with circulating steam at 100°C for 30 minutes.
example 2
[0016] (1) Take 10ml of water for injection, add 0.3g of thiourea and sodium bisulfite and stir to dissolve, add 30ml of α-pyrrolidone and 35ml of propylene glycol, and stir evenly;
[0017] (2) Weigh 3.5g of MgO, add to 1 solution and stir evenly, then add 23g of doxycycline hydrochloride, stir until clear liquid, adjust pH to 6.5 with concentrated hydrochloric acid.
[0018] (3) Filter with a 0.45mm organic membrane, pack in ampoules, and sterilize with circulating steam at 100°C for 30 minutes.
example 3
[0020] (1) Take 10ml of water for injection, add 0.2g of sodium bisulfite and L-semilight amine hydrochloride respectively and stir to dissolve, then weigh 16.4g of Mgcl2.6H2O, stir and dissolve, add 40ml of α-pyrrolidone and dimethyl ethyl Amide 25ml, stir well;
[0021] (2) Weigh 23g of doxycycline hydrochloride, add it to 1 solution and stir until it becomes a clear liquid, and adjust the pH to 3.0.
[0022] (3) Filter with a 0.45mm organic membrane, pack in ampoules, and sterilize with circulating steam at 100°C for 30 minutes.
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Abstract
The invention discloses a composition of animal doxycycline hydrochloride injection and a process for making the same, belonging to the animal medicine technical field. The injection consists of principal medicine, solvent, a doxycycline hydrochloride complexing agent and antioxidant, wherein metal ion (Mg<2+>) of higher content is used as the doxycycline hydrochloride complexing agent so as to remarkably increase the solubility and the pH value of the doxycycline hydrochloride and to reinforce the stability of the injection at the same time; above all, the toxicity and the tissue irritation of medicine are reduced after complexation. Dissolvant mixed by 2-pyrrolidone and propylene glycol or dimethyl acetamide is used as solvent so as to increase the stability of the injection; therefore, the injection can not be separated out and frozen under a low-temperature (4 DEG C) condition; moreover, concentrated hydrochloric acid and ethanolamine are used as pH regulator. The invention develops the high-content doxycycline hydrochloride injection for veterinary clinic, and the injection has advanced process, convenient use and remarkable curative effect.
Description
technical field [0001] The invention belongs to the technical field of veterinary medicines, in particular to a composition and a preparation process of veterinary doxycycline hydrochloride injection. Background technique [0002] Doxycycline Hydrochloride (Doxycycline Hydrochloride), also known as deoxyoxytetracycline hydrochloride, the molecular formula is C 22 h 24 N 2 o 8 ·HCl.1 / 2C 2 h 5 OH.1 / 2H20, the molecular weight is 512.93; this product is a semi-synthetic broad-spectrum antibiotic, a tetracycline antibiotic obtained by modifying its molecular structure with oxytetracycline, its fat solubility is significantly stronger than that of tetracycline and oxytetracycline, and its antibacterial spectrum It is the same as tetracycline, but its activity in vivo and in vitro is stronger than that of oxytetracycline and tetracycline. It is absorbed quickly when taken orally, has high bioavailability, maintains effective blood concentration for a long time, has strong pene...
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